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• W2057443386 abstract "There have been many applications of the peaceful use of the atom. Probably none have been as effective as the radiopharmaceuticals developed to better understand human biology and to improve patient care through diagnosis or radiotherapy [1]. The latter goal is the focus of this review using parallel approaches in the pharmaceutical industry as a reference point for the development of new radiopharmaceuticals. In this review, we emphasize translational radiopharmaceutical developmentwith the goal of translating radiopharmaceuticals to human imagingwith the goal to impact patient health. This goal does not preclude the development of imaging agents with purely scientific goals; however, the emphasis of this review is on the compounds most likely to have an impact on patient treatment. Several nuclear medicine societies and journals have changed their names recently by adding molecular imaging to their previous titles [2]. But molecular imaging, which is synonymous with targeted imaging, has been a major part of radiopharmaceutical development from the 70s, dictated by the nature of external imaging. External radiotracer imaging is perhaps best described as a method of converting photon emissions (whether emission from positron annihilation or single photon emission) to biological metrics. This can best be achieved when the radioligand interacts with a single receptor or enzymatic protein and is either bound or is metabolically trapped as is [F]fludeoxyglucose as the 6-phosphate. There are several examples of targeted radioligands that when studied in humans yielded biological information some of which went forward to gain human use approval (Table 1). By the nature of external imaging, monitoring a single biochemical target, the so-called molecular target screening approach, compared to the phenotypic screening approach,which involves several biochemical entities, is an important distinction [3]. The single target is the end goal and does not preclude other biochemical steps, but does not lead to more than one final target. Radioligands that measure myocardial or cerebral flow and clearance by renal or hepatic pathways can be considered targeted molecules but with a high capacity target [4]." @default.
• W2057443386 created "2016-06-24" @default.
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• W2057443386 date "2015-05-01" @default.
• W2057443386 modified "2023-10-04" @default.
• W2057443386 title "Choosing a single target as a biomarker or therapeutic using radioactive probes" @default.
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• W2057443386 doi "https://doi.org/10.1016/j.nucmedbio.2015.01.005" @default.
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