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• W2057445965 abstract "Objective To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy. Methods Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60–64 years free from dementia, mild cognitive impairment, and other neurological disorders. Results SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology. Conclusion Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries. To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy. Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60–64 years free from dementia, mild cognitive impairment, and other neurological disorders. SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology. Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries." @default.
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• W2057445965 date "2015-05-01" @default.
• W2057445965 modified "2023-10-18" @default.
• W2057445965 title "Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study" @default.
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• W2057445965 doi "https://doi.org/10.1016/j.jagp.2014.07.009" @default.
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