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- W2057453398 abstract "Chlorpyrifos is a pesticide, member of the organophosphate class, widely used in several countries to manage insect pests on many agricultural crops. Currently, chlorpyrifos health risks are being reevaluated due to possible adverse effects, especially on the central nervous system. The aim of this study was to investigate the possible action of this pesticide on the behaviors related to anxiety and depression of offspring rats exposed during pregnancy. Wistar rats were treated orally with chlorpyrifos (0.01, 0.1, 1 and 10 mg/kg/day) on gestational days 14–20. Male offspring behavior was evaluated on post-natal days 21 and 70 by the elevated plus-maze test, open field test and forced swimming test. The results demonstrated that exposure to 0.1, 1 or 10 mg/kg/day of chlorpyrifos could induce anxiogenic-like, but not depressive-like behavior at post-natal day 21, without causing fetal toxicity. This effect was reversed on post-natal day 70." @default.
- W2057453398 created "2016-06-24" @default.
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- W2057453398 date "2006-01-01" @default.
- W2057453398 modified "2023-09-28" @default.
- W2057453398 title "8-OH-DPAT in combination with galantamine decreases anxiety in old male rats with Alzheimer's type amnesia" @default.
- W2057453398 doi "https://doi.org/10.1016/s0924-977x(06)80105-7" @default.
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