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- W2057459783 abstract "T cell maturation was once thought to occur entirely within the thymus. Now, evidence is mounting that the youngest peripheral T cells in both mice and humans comprise a distinct population from their more mature, yet still naive, counterparts. These cells, termed recent thymic emigrants (RTEs), undergo a process of post-thymic maturation that can be monitored at the levels of cell phenotype and immune function. Understanding this final maturation step in the process of generating useful and safe T cells is of clinical relevance, given that RTEs are over-represented in neonates and in adults recovering from lymphopenia. Post-thymic maturation may function to ensure T cell fitness and self tolerance." @default.
- W2057459783 created "2016-06-24" @default.
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- W2057459783 date "2011-07-22" @default.
- W2057459783 modified "2023-09-25" @default.
- W2057459783 title "Post-thymic maturation: young T cells assert their individuality" @default.
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- W2057459783 doi "https://doi.org/10.1038/nri3028" @default.
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