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- W2057459861 abstract "Glycosaminoglycans were prepared from the Engelbreth-Holm-Swarm mouse tumor. Enzymatic analysis demonstrated heparan sulfate (95.8%) and chondroitinase ABC-sensitive galactosaminoglycans (4.2%). HPLC analysis of the disaccharide units showed that heparan sulfate chains were undersulfated on average, comprizing approximately 30% nonsulfated and 60% N-sulfated disaccharide units with small proportions of other monosulfated and disulfated disaccharide units. In contrast, galactosaminoglycan chains were oversulfated, containing an appreciable proportion (15%) of a 4,6-disulfated (so-called E-type) disaccharide unit in addition to 51% of a 4-sulfated, 22% of a 6-sulfated, and 11% of a nonsulfated disaccharide unit. The significance of the oversulfated disaccharide structure is discussed in relation to the possible regulation of functions of hybrid proteoglycans from which the galactosaminolycan chains are derived." @default.
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- W2057459861 date "1989-07-01" @default.
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- W2057459861 title "The engelbreth-holm-swarm mouse tumor produces undersulfated heparan sulfate and oversulfated galactosaminoglycans" @default.
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- W2057459861 doi "https://doi.org/10.1016/0006-291x(89)91980-3" @default.
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