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- W2057471844 abstract "The N-terminal substance P fragment SP1–7 is known to modulate hyperalgesia and opioid withdrawal in animal models. This study examined the effects of intraperitoneal (i.p.) injections of SP1–7 on chronic morphine tolerance and on the levels of dynorphin B (DYN B) and nociceptin/orphanin FQ (N/OFQ) in various brain areas of male Sprague–Dawley rats. Morphine tolerance was induced by subcutaneous injections of the opioid (10 mg/kg) twice daily for 7 days. SP1–7 injected i.p. (185 nmol/kg) 30 min prior to morphine reduced the development of morphine tolerance. Immunoreactive (ir) DYN B and N/OFQ peptide levels were measured in several areas of the central nervous system. Levels of ir DYN B in rats treated with SP1–7 and morphine were decreased in the nucleus accumbens, substantia nigra and ventral tegmental area and increased in the frontal cortex. The ir N/OFQ levels were increased in the periaqueductal gray and decreased in the nucleus accumbens. Since the concentration profiles of the two peptides were altered by SP1–7 in the areas that are implicated in the modulation of opioid tolerance and analgesia, it is suggested that DYN B and N/OFQ systems may be involved in the effects of SP1–7 on opioid tolerance." @default.
- W2057471844 created "2016-06-24" @default.
- W2057471844 creator A5037716681 @default.
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- W2057471844 date "2011-08-01" @default.
- W2057471844 modified "2023-10-17" @default.
- W2057471844 title "Substance P N-terminal fragment SP(1–7) attenuates chronic morphine tolerance and affects dynorphin B and nociceptin in rats" @default.
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- W2057471844 doi "https://doi.org/10.1016/j.peptides.2011.06.030" @default.
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