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• W2057476469 abstract "La morbimortalidad por causas cardiovasculares en pacientes con esquizofrenia es superior a la de la población general, hecho que se ha puesto más de manifiesto desde la generalización del uso de antipsicóticos de segunda generación. Examinar la incidencia del síndrome metabólico tras seis meses de tratamiento antipsicótico en pacientes con un primer episodio psicótico no tratado con anterioridad y determinar cambios prospectivos en los parámetros que definen los criterios del síndrome metabólico. Estudio observacional con diseño de cohortes prospectivo incluyendo pacientes que ingresaron en la unidad de agudos del Hospital Donostia. Veintiún pacientes fueron incluidos en el estudio, completando el mismo 19. Un 26,3% de los pacientes desarrollaron síndrome metabólico a los 6 meses. Se observaron diferencias estadísticamente significativas en los siguientes parámetros: 1) medida del perímetro abdominal con un incremento de 14,6 cm a los 6 meses (p = 0,001); 2) niveles de triglicéridos con un incremento medio sobre la medida inicial de 48,99 mg/dl (p = 0,039); 3) niveles de glucosa en ayunas con un aumento medio de 10,72 mg/dl (p = 0,001). Se observaron importantes cambios en los parámetros metabólicos en un periodo corto con el consiguiente riesgo de eventos cardiovasculares asociado en un grupo de pacientes jóvenes. Son necesarias intervenciones dirigidas a asegurar una correcta monitorización de estos pacientes que permitan llevar a cabo medidas para minimizar riesgos. The morbidity and mortality due to cardiovascular causes in patients with schizophrenia is higher than in the general population, a fact that has been observed more since second generation anti-psychotics came into general use. To determine the incidence of metabolic syndrome in patients with a previously untreated first psychotic episode, as well as the prospective changes in the parameters that define the criteria of metabolic syndrome. An observational study with a prospective cohort design including patients who were admitted to the Acute Unit of Donostia Hospital. A total of 21 patients were included in the study, of which 19 completed it. Just over one-quarter (26.3%) of the patients developed a metabolic syndrome at six months. Statistically significant differences were observed in the following parameters: 1) abdominal perimeter measurement with an increase of 14.6 cm at six months (P=.001); 2) triglyceride levels with a mean increase over the initial measurement of 48.99 mg/dl (P=.039); and 3) fasting blood glucose levels with a mean increase of 10.72 mg/dl (P=.001). Significant changes were observed in metabolic parameters in a short period with the subsequent risk of associated cardiovascular events in a group of young patients. Actions are required directed at ensuring appropriate monitoring of these patients in order to measures to minimise the risks." @default.
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• W2057476469 date "2013-01-01" @default.
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• W2057476469 title "Tras 6 meses de tratamiento antipsicótico: ¿mejoría de la salud mental a costa de la salud física?" @default.
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