FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057477562> ?p ?o ?g. }

• W2057477562 endingPage "563" @default.
• W2057477562 startingPage "554" @default.
• W2057477562 abstract "Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear receptor that regulates diverse biological functions including inflammation. The PPARgamma ligands have been reported to exert cardioprotective effects and attenuate myocardial reperfusion injury. Here, we examined the molecular mechanisms of their anti-inflammatory effects. Male Wistar rats were subjected to myocardial ischemia and reperfusion and were treated with the PPAR-gamma ligands, 15-deoxy-Delta-prostaglandin J2 (15d-PGJ2) or ciglitazone, or with vehicle only, in the absence or presence of the selective PPAR-gamma antagonist GW-9662. In vehicle-treated rats, myocardial injury was associated with elevated tissue activity of myeloperoxidase, indicating infiltration of neutrophils, and elevated plasma levels of creatine kinase and tumor necrosis factor-alpha. These events were preceded by activation of the nuclear factor-kappaB pathway. The PPAR-gamma DNA binding was also increased in the heart after reperfusion. Treatment with ciglitazone or 15d-PGJ2 reduced myocardial damage and neutrophil infiltration and blunted creatine kinase levels and cytokine production. The beneficial effects of both ligands were associated with enhancement of PPAR-gamma DNA binding and reduction of nuclear factor-kappaB activation. Treatment with 15d-PGJ2, but not ciglitazone, enhanced DNA binding of heat shock factor 1 and upregulated the expression of the cardioprotective heat shock protein 70. Treatment with 15d-PGJ2, but not ciglitazone, also induced a significant increase in nuclear phosphorylation of the prosurvival kinase Akt. The cardioprotection afforded by ciglitazone was attenuated by the PPAR-gamma antagonist GW-9662. In contrast, GW-9662 did not affect the beneficial effects afforded by 15d-PGJ2. Thus, our data suggest that treatment with these chemically unrelated PPAR-gamma ligands results in diverse anti-inflammatory mechanisms." @default.
• W2057477562 created "2016-06-24" @default.
• W2057477562 creator A5001304467 @default.
• W2057477562 creator A5018734910 @default.
• W2057477562 creator A5020609229 @default.
• W2057477562 creator A5042280234 @default.
• W2057477562 creator A5047917681 @default.
• W2057477562 creator A5064429725 @default.
• W2057477562 creator A5067994454 @default.
• W2057477562 creator A5069969929 @default.
• W2057477562 date "2007-11-01" @default.
• W2057477562 modified "2023-10-16" @default.
• W2057477562 title "DIVERSE CARDIOPROTECTIVE SIGNALING MECHANISMS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ LIGANDS, 15-DEOXY-Δ12,14-PROSTAGLANDIN J2 AND CIGLITAZONE, IN REPERFUSION INJURY" @default.
• W2057477562 cites W1516501648 @default.
• W2057477562 cites W1539392991 @default.
• W2057477562 cites W1582022233 @default.
• W2057477562 cites W1633340712 @default.
• W2057477562 cites W1812573520 @default.
• W2057477562 cites W1847379925 @default.
• W2057477562 cites W1978065594 @default.
• W2057477562 cites W1981946836 @default.
• W2057477562 cites W1983247838 @default.
• W2057477562 cites W1989665685 @default.
• W2057477562 cites W1994908701 @default.
• W2057477562 cites W1999730887 @default.
• W2057477562 cites W2020364059 @default.
• W2057477562 cites W2020785271 @default.
• W2057477562 cites W2023097850 @default.
• W2057477562 cites W2023988777 @default.
• W2057477562 cites W2030874973 @default.
• W2057477562 cites W2048401395 @default.
• W2057477562 cites W2050717908 @default.
• W2057477562 cites W2050895281 @default.
• W2057477562 cites W2051055391 @default.
• W2057477562 cites W2058526434 @default.
• W2057477562 cites W2060123865 @default.
• W2057477562 cites W2061946173 @default.
• W2057477562 cites W2064208521 @default.
• W2057477562 cites W2065133286 @default.
• W2057477562 cites W2071211356 @default.
• W2057477562 cites W2074579328 @default.
• W2057477562 cites W2077137794 @default.
• W2057477562 cites W2086414722 @default.
• W2057477562 cites W2088258188 @default.
• W2057477562 cites W2089687829 @default.
• W2057477562 cites W2093814798 @default.
• W2057477562 cites W2100677911 @default.
• W2057477562 cites W2107326660 @default.
• W2057477562 cites W2112300191 @default.
• W2057477562 cites W2130091960 @default.
• W2057477562 cites W2133941138 @default.
• W2057477562 cites W2134745341 @default.
• W2057477562 cites W2141123335 @default.
• W2057477562 cites W2146016839 @default.
• W2057477562 cites W2147791296 @default.
• W2057477562 cites W2150765336 @default.
• W2057477562 cites W2151884159 @default.
• W2057477562 cites W2156336479 @default.
• W2057477562 cites W2157008873 @default.
• W2057477562 cites W2159976029 @default.
• W2057477562 cites W2162975453 @default.
• W2057477562 cites W4247315158 @default.
• W2057477562 cites W4297846776 @default.
• W2057477562 doi "https://doi.org/10.1097/shk.0b013e31804f56b9" @default.
• W2057477562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17589386" @default.
• W2057477562 hasPublicationYear "2007" @default.
• W2057477562 type Work @default.
• W2057477562 sameAs 2057477562 @default.
• W2057477562 citedByCount "52" @default.
• W2057477562 countsByYear W20574775622012 @default.
• W2057477562 countsByYear W20574775622014 @default.
• W2057477562 countsByYear W20574775622015 @default.
• W2057477562 countsByYear W20574775622016 @default.
• W2057477562 countsByYear W20574775622017 @default.
• W2057477562 countsByYear W20574775622018 @default.
• W2057477562 countsByYear W20574775622019 @default.
• W2057477562 countsByYear W20574775622021 @default.
• W2057477562 countsByYear W20574775622023 @default.
• W2057477562 crossrefType "journal-article" @default.
• W2057477562 hasAuthorship W2057477562A5001304467 @default.
• W2057477562 hasAuthorship W2057477562A5018734910 @default.
• W2057477562 hasAuthorship W2057477562A5020609229 @default.
• W2057477562 hasAuthorship W2057477562A5042280234 @default.
• W2057477562 hasAuthorship W2057477562A5047917681 @default.
• W2057477562 hasAuthorship W2057477562A5064429725 @default.
• W2057477562 hasAuthorship W2057477562A5067994454 @default.
• W2057477562 hasAuthorship W2057477562A5069969929 @default.
• W2057477562 hasBestOaLocation W20574775621 @default.
• W2057477562 hasConcept C126322002 @default.
• W2057477562 hasConcept C134018914 @default.
• W2057477562 hasConcept C170493617 @default.
• W2057477562 hasConcept C185592680 @default.
• W2057477562 hasConcept C187345961 @default.
• W2057477562 hasConcept C2780963305 @default.
• W2057477562 hasConcept C71924100 @default.
• W2057477562 hasConcept C86803240 @default.
• W2057477562 hasConcept C98274493 @default.
• W2057477562 hasConceptScore W2057477562C126322002 @default.

• next