FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057479214> ?p ?o ?g. }

• W2057479214 endingPage "1184" @default.
• W2057479214 startingPage "1176" @default.
• W2057479214 abstract "Because many patients do not respond to pharmacotherapy for generalized anxiety disorder (GAD), it would be beneficial to know if early response is predictive of final outcome so that timely clinical decisions can be made about augmentation or alternative treatments. This topic has not been examined with the now recommended first-line treatments (selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors) for GAD. Combined data from three 9 to 10week acute treatment, multi-center, randomized, placebo-controlled studies of duloxetine for GAD were used to explore early improvement on the Hamilton Anxiety Rating Scale (HAMA) in relation to endpoint HAMA response (> or = 50% improvement from baseline), HAMA remission (< or = 7), Clinical Global Impression-Improvement (CGI-I) response (< or = 2), and functional remission as measured by the Sheehan Disability Scale Global Functional Improvement (< or = 5). For duloxetine-treated patients (n=668), the relationships between the proportion of patients who achieved each category of early (week 2 and week 4) HAMA improvement (> or = 20%, > or = 40%, > or = 60%, and > or = 80%) and achievement of endpoint HAMA response, HAMA remission, CGI response, and SDS remission status were all statistically significant (all P's < or = 0.003). One hundred percent of the duloxetine-treated patients who showed substantial HAMA improvement (>80%) at week 2, and 93% at week 4, were HAMA responders at endpoint. At week 2, 79% of the duloxetine-treated patients who achieved a HAMA improvement of 40-59% were HAMA responders at endpoint. About half of duloxetine-treated patient showing 40-59% early HAMA improvement were remitters on the SDS at endpoint. These data suggest a connection between early improvement and endpoint response and remission status that can be used to guide clinical decision-making." @default.
• W2057479214 created "2016-06-24" @default.
• W2057479214 creator A5025291909 @default.
• W2057479214 creator A5047478186 @default.
• W2057479214 creator A5061223764 @default.
• W2057479214 creator A5063618224 @default.
• W2057479214 creator A5065758533 @default.
• W2057479214 creator A5068545843 @default.
• W2057479214 date "2008-10-01" @default.
• W2057479214 modified "2023-10-16" @default.
• W2057479214 title "Early improvement during duloxetine treatment of generalized anxiety disorder predicts response and remission at endpoint" @default.
• W2057479214 cites W1975234279 @default.
• W2057479214 cites W198074757 @default.
• W2057479214 cites W1993810702 @default.
• W2057479214 cites W2005818204 @default.
• W2057479214 cites W2010561328 @default.
• W2057479214 cites W2025707558 @default.
• W2057479214 cites W2043211915 @default.
• W2057479214 cites W2044509481 @default.
• W2057479214 cites W2045477379 @default.
• W2057479214 cites W2048519309 @default.
• W2057479214 cites W2049804854 @default.
• W2057479214 cites W2053707526 @default.
• W2057479214 cites W2057286542 @default.
• W2057479214 cites W2058667310 @default.
• W2057479214 cites W2061469083 @default.
• W2057479214 cites W2064659434 @default.
• W2057479214 cites W2076728061 @default.
• W2057479214 cites W2114792171 @default.
• W2057479214 cites W2118826874 @default.
• W2057479214 cites W2121528518 @default.
• W2057479214 cites W2123686084 @default.
• W2057479214 cites W2140746866 @default.
• W2057479214 cites W2146490418 @default.
• W2057479214 cites W2166281097 @default.
• W2057479214 cites W2170684975 @default.
• W2057479214 doi "https://doi.org/10.1016/j.jpsychires.2008.02.002" @default.
• W2057479214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18348888" @default.
• W2057479214 hasPublicationYear "2008" @default.
• W2057479214 type Work @default.
• W2057479214 sameAs 2057479214 @default.
• W2057479214 citedByCount "36" @default.
• W2057479214 countsByYear W20574792142012 @default.
• W2057479214 countsByYear W20574792142013 @default.
• W2057479214 countsByYear W20574792142014 @default.
• W2057479214 countsByYear W20574792142015 @default.
• W2057479214 countsByYear W20574792142016 @default.
• W2057479214 countsByYear W20574792142017 @default.
• W2057479214 countsByYear W20574792142020 @default.
• W2057479214 countsByYear W20574792142022 @default.
• W2057479214 countsByYear W20574792142023 @default.
• W2057479214 crossrefType "journal-article" @default.
• W2057479214 hasAuthorship W2057479214A5025291909 @default.
• W2057479214 hasAuthorship W2057479214A5047478186 @default.
• W2057479214 hasAuthorship W2057479214A5061223764 @default.
• W2057479214 hasAuthorship W2057479214A5063618224 @default.
• W2057479214 hasAuthorship W2057479214A5065758533 @default.
• W2057479214 hasAuthorship W2057479214A5068545843 @default.
• W2057479214 hasConcept C118552586 @default.
• W2057479214 hasConcept C126322002 @default.
• W2057479214 hasConcept C142724271 @default.
• W2057479214 hasConcept C15744967 @default.
• W2057479214 hasConcept C168563851 @default.
• W2057479214 hasConcept C203092338 @default.
• W2057479214 hasConcept C204787440 @default.
• W2057479214 hasConcept C27081682 @default.
• W2057479214 hasConcept C2776000289 @default.
• W2057479214 hasConcept C2777696351 @default.
• W2057479214 hasConcept C2779177272 @default.
• W2057479214 hasConcept C2779911313 @default.
• W2057479214 hasConcept C2780764818 @default.
• W2057479214 hasConcept C2910564767 @default.
• W2057479214 hasConcept C31487548 @default.
• W2057479214 hasConcept C558461103 @default.
• W2057479214 hasConcept C71924100 @default.
• W2057479214 hasConceptScore W2057479214C118552586 @default.
• W2057479214 hasConceptScore W2057479214C126322002 @default.
• W2057479214 hasConceptScore W2057479214C142724271 @default.
• W2057479214 hasConceptScore W2057479214C15744967 @default.
• W2057479214 hasConceptScore W2057479214C168563851 @default.
• W2057479214 hasConceptScore W2057479214C203092338 @default.
• W2057479214 hasConceptScore W2057479214C204787440 @default.
• W2057479214 hasConceptScore W2057479214C27081682 @default.
• W2057479214 hasConceptScore W2057479214C2776000289 @default.
• W2057479214 hasConceptScore W2057479214C2777696351 @default.
• W2057479214 hasConceptScore W2057479214C2779177272 @default.
• W2057479214 hasConceptScore W2057479214C2779911313 @default.
• W2057479214 hasConceptScore W2057479214C2780764818 @default.
• W2057479214 hasConceptScore W2057479214C2910564767 @default.
• W2057479214 hasConceptScore W2057479214C31487548 @default.
• W2057479214 hasConceptScore W2057479214C558461103 @default.
• W2057479214 hasConceptScore W2057479214C71924100 @default.
• W2057479214 hasIssue "14" @default.
• W2057479214 hasLocation W20574792141 @default.
• W2057479214 hasLocation W20574792142 @default.
• W2057479214 hasOpenAccess W2057479214 @default.
• W2057479214 hasPrimaryLocation W20574792141 @default.
• W2057479214 hasRelatedWork W1971663696 @default.

• next