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- W2057484074 abstract "Post-traumatic stress disorder (PTSD) is a psychiatric condition characterized by intrusive and persistent memories of a psychologically traumatic event that leads to significant functional and social impairment in affected individuals. The molecular bases underlying persistent outcomes of a transient traumatic event have remained elusive for many years, but recent studies in rodents have implicated epigenetic modifications of chromatin structure and DNA methylation as fundamental mechanisms for the induction and stabilization of fear memory. In addition to mediating adaptations to traumatic events that ultimately cause PTSD, epigenetic mechanisms are also involved in establishing individual differences in PTSD risk and resilience by mediating long-lasting effects of genes and early environment on adult function and behavior. In this review, we discuss the current evidence for epigenetic regulation of PTSD in human studies and in animal models and comment on ways in which these models can be expanded. In addition, we identify key outstanding questions in the study of epigenetic mechanisms of PTSD in the context of rapidly evolving technologies that are constantly updating and adjusting our understanding of epigenetic modifications and their functional roles. Finally, we discuss the potential application of epigenetic approaches in identifying markers of risk and resilience that can be utilized to promote early intervention and develop therapeutic strategies to combat PTSD after symptom onset." @default.
- W2057484074 created "2016-06-24" @default.
- W2057484074 creator A5021377062 @default.
- W2057484074 creator A5023498677 @default.
- W2057484074 creator A5053267978 @default.
- W2057484074 creator A5063005937 @default.
- W2057484074 date "2013-01-01" @default.
- W2057484074 modified "2023-10-08" @default.
- W2057484074 title "Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD" @default.
- W2057484074 cites W122152837 @default.
- W2057484074 cites W1481609790 @default.
- W2057484074 cites W1484741277 @default.
- W2057484074 cites W1523349613 @default.
- W2057484074 cites W1543244495 @default.
- W2057484074 cites W1545854379 @default.
- W2057484074 cites W1572556665 @default.
- W2057484074 cites W1583890050 @default.
- W2057484074 cites W1718946028 @default.
- W2057484074 cites W1753989155 @default.
- W2057484074 cites W1874007049 @default.
- W2057484074 cites W1920958927 @default.
- W2057484074 cites W1964261039 @default.
- W2057484074 cites W1964536180 @default.
- W2057484074 cites W1966629540 @default.
- W2057484074 cites W1967340797 @default.
- W2057484074 cites W1969052595 @default.
- W2057484074 cites W1969267302 @default.
- W2057484074 cites W1969500227 @default.
- W2057484074 cites W1970003449 @default.
- W2057484074 cites W1970210902 @default.
- W2057484074 cites W1970998739 @default.
- W2057484074 cites W1971231611 @default.
- W2057484074 cites W1971334707 @default.
- W2057484074 cites W1971407164 @default.
- W2057484074 cites W1971951429 @default.
- W2057484074 cites W1973730114 @default.
- W2057484074 cites W1974849634 @default.
- W2057484074 cites W1975264600 @default.
- W2057484074 cites W1976507388 @default.
- W2057484074 cites W1976735983 @default.
- W2057484074 cites W1979526394 @default.
- W2057484074 cites W1979606094 @default.
- W2057484074 cites W1979921881 @default.
- W2057484074 cites W1981148439 @default.
- W2057484074 cites W1981354816 @default.
- W2057484074 cites W1981543052 @default.
- W2057484074 cites W1981890056 @default.
- W2057484074 cites W1983267120 @default.
- W2057484074 cites W1984431340 @default.
- W2057484074 cites W1984783889 @default.
- W2057484074 cites W1985582399 @default.
- W2057484074 cites W1985675810 @default.
- W2057484074 cites W1985867301 @default.
- W2057484074 cites W1987071871 @default.
- W2057484074 cites W1987874272 @default.
- W2057484074 cites W1988011200 @default.
- W2057484074 cites W1989190822 @default.
- W2057484074 cites W1989423984 @default.
- W2057484074 cites W1989457196 @default.
- W2057484074 cites W1990689143 @default.
- W2057484074 cites W1992989737 @default.
- W2057484074 cites W1993415518 @default.
- W2057484074 cites W1994388155 @default.
- W2057484074 cites W1994674729 @default.
- W2057484074 cites W1994740828 @default.
- W2057484074 cites W1995021156 @default.
- W2057484074 cites W1995502179 @default.
- W2057484074 cites W1995759170 @default.
- W2057484074 cites W1996676239 @default.
- W2057484074 cites W1996961540 @default.
- W2057484074 cites W1997453048 @default.
- W2057484074 cites W1997678698 @default.
- W2057484074 cites W1998742722 @default.
- W2057484074 cites W1998769481 @default.
- W2057484074 cites W1999282071 @default.
- W2057484074 cites W1999284470 @default.
- W2057484074 cites W1999616055 @default.
- W2057484074 cites W1999833210 @default.
- W2057484074 cites W2001158321 @default.
- W2057484074 cites W2002698073 @default.
- W2057484074 cites W2003217864 @default.
- W2057484074 cites W2005102053 @default.
- W2057484074 cites W2006574212 @default.
- W2057484074 cites W2010629311 @default.
- W2057484074 cites W2011110841 @default.
- W2057484074 cites W2012116025 @default.
- W2057484074 cites W2015734897 @default.
- W2057484074 cites W2016095773 @default.
- W2057484074 cites W2018161111 @default.
- W2057484074 cites W2018309119 @default.
- W2057484074 cites W2018389427 @default.
- W2057484074 cites W2018570511 @default.
- W2057484074 cites W2019883630 @default.
- W2057484074 cites W2020257351 @default.
- W2057484074 cites W2020506534 @default.
- W2057484074 cites W2020767030 @default.
- W2057484074 cites W2021643106 @default.
- W2057484074 cites W2022085232 @default.
- W2057484074 cites W2022181907 @default.
- W2057484074 cites W2022768282 @default.