FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057485733> ?p ?o ?g. }

• W2057485733 endingPage "15" @default.
• W2057485733 startingPage "1" @default.
• W2057485733 abstract "Hypercoagulation often occurs in type 2 diabetes, suggesting pleiotropy of the genes that influence disease liability and hemostasis-related phenotypes. To better understand the relationship between hemostasis and diabetes, we first used maximum-likelihood methods to estimate the relative contribution of additive genetic, measured environmental, and shared household effects to the normal variance of 16 hemostasis-related traits in 813 individuals participating in the San Antonio Family Heart Study. We estimated moderate to high heritabilities (0.20–0.60) for each phenotype. Von Willebrand factor (VWF), thrombin activatable fibrinolysis inhibitor, activated protein C (APC) ratio, factor V, and prothrombin time had heritabilities greater than 0.50. The correlation between type 2 diabetes status and the hemostasis-related traits was then partitioned into genetic and environmental components using bivariate variance-components methods. Significant (p le0.05) positive genetic correlations (0.37–0.51) occurred with factors II and VIII, VWF, total protein S (tPS), and tissue factor pathway inhibitor. Significant negative genetic correlations were estimated for activated partial thromboplastin time (-0.49) and APC ratio (-0.38). By contrast, significant environmental correlations occurred only with factor II (-0.40) and tPS (-0.31). Our results suggest that genes are important contributors to the normal variation in hemostasis-related traits and that genes influencing hemostasis-related traits pleiotropically influence diabetes risk." @default.
• W2057485733 created "2016-06-24" @default.
• W2057485733 creator A5001935511 @default.
• W2057485733 creator A5004538115 @default.
• W2057485733 creator A5017144351 @default.
• W2057485733 creator A5028529427 @default.
• W2057485733 creator A5043180844 @default.
• W2057485733 creator A5063555195 @default.
• W2057485733 creator A5079020015 @default.
• W2057485733 creator A5087753151 @default.
• W2057485733 date "2005-01-01" @default.
• W2057485733 modified "2023-09-26" @default.
• W2057485733 title "Heritability of Hemostasis Phenotypes and Their Correlation with Type 2 Diabetes Status in Mexican Americans" @default.
• W2057485733 cites W141165294 @default.
• W2057485733 cites W1514226843 @default.
• W2057485733 cites W1651383390 @default.
• W2057485733 cites W176430369 @default.
• W2057485733 cites W1965958910 @default.
• W2057485733 cites W1973669459 @default.
• W2057485733 cites W1976178291 @default.
• W2057485733 cites W1977497608 @default.
• W2057485733 cites W1979315245 @default.
• W2057485733 cites W1980648524 @default.
• W2057485733 cites W1990107586 @default.
• W2057485733 cites W1990905803 @default.
• W2057485733 cites W1991083291 @default.
• W2057485733 cites W1994536191 @default.
• W2057485733 cites W1995474189 @default.
• W2057485733 cites W2015844309 @default.
• W2057485733 cites W2033575106 @default.
• W2057485733 cites W2041566064 @default.
• W2057485733 cites W2050943729 @default.
• W2057485733 cites W2055198158 @default.
• W2057485733 cites W2055335489 @default.
• W2057485733 cites W2065620480 @default.
• W2057485733 cites W2069343109 @default.
• W2057485733 cites W2073273161 @default.
• W2057485733 cites W2079944343 @default.
• W2057485733 cites W2084124265 @default.
• W2057485733 cites W2085206785 @default.
• W2057485733 cites W2092362047 @default.
• W2057485733 cites W2098281394 @default.
• W2057485733 cites W2105736694 @default.
• W2057485733 cites W2107137688 @default.
• W2057485733 cites W2108082148 @default.
• W2057485733 cites W2115335486 @default.
• W2057485733 cites W2117767595 @default.
• W2057485733 cites W2125264632 @default.
• W2057485733 cites W2129558981 @default.
• W2057485733 cites W2133640678 @default.
• W2057485733 cites W2135158117 @default.
• W2057485733 cites W2139210573 @default.
• W2057485733 cites W2140429097 @default.
• W2057485733 cites W2141244940 @default.
• W2057485733 cites W2169509672 @default.
• W2057485733 cites W2251348755 @default.
• W2057485733 cites W2329570319 @default.
• W2057485733 cites W2410199296 @default.
• W2057485733 cites W2417488736 @default.
• W2057485733 cites W2464006309 @default.
• W2057485733 cites W2639857859 @default.
• W2057485733 cites W2681948028 @default.
• W2057485733 cites W70958897 @default.
• W2057485733 doi "https://doi.org/10.1353/hub.2005.0034" @default.
• W2057485733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16114812" @default.
• W2057485733 hasPublicationYear "2005" @default.
• W2057485733 type Work @default.
• W2057485733 sameAs 2057485733 @default.
• W2057485733 citedByCount "26" @default.
• W2057485733 countsByYear W20574857332012 @default.
• W2057485733 countsByYear W20574857332013 @default.
• W2057485733 countsByYear W20574857332014 @default.
• W2057485733 countsByYear W20574857332015 @default.
• W2057485733 countsByYear W20574857332016 @default.
• W2057485733 countsByYear W20574857332017 @default.
• W2057485733 countsByYear W20574857332020 @default.
• W2057485733 countsByYear W20574857332021 @default.
• W2057485733 countsByYear W20574857332022 @default.
• W2057485733 crossrefType "journal-article" @default.
• W2057485733 hasAuthorship W2057485733A5001935511 @default.
• W2057485733 hasAuthorship W2057485733A5004538115 @default.
• W2057485733 hasAuthorship W2057485733A5017144351 @default.
• W2057485733 hasAuthorship W2057485733A5028529427 @default.
• W2057485733 hasAuthorship W2057485733A5043180844 @default.
• W2057485733 hasAuthorship W2057485733A5063555195 @default.
• W2057485733 hasAuthorship W2057485733A5079020015 @default.
• W2057485733 hasAuthorship W2057485733A5087753151 @default.
• W2057485733 hasConcept C104201883 @default.
• W2057485733 hasConcept C104317684 @default.
• W2057485733 hasConcept C126322002 @default.
• W2057485733 hasConcept C127716648 @default.
• W2057485733 hasConcept C134018914 @default.
• W2057485733 hasConcept C161890455 @default.
• W2057485733 hasConcept C26207810 @default.
• W2057485733 hasConcept C2776825266 @default.
• W2057485733 hasConcept C2777180221 @default.
• W2057485733 hasConcept C2778261982 @default.
• W2057485733 hasConcept C2778382381 @default.

• next