FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057491036> ?p ?o ?g. }

• W2057491036 endingPage "238" @default.
• W2057491036 startingPage "236" @default.
• W2057491036 abstract "This editorial links to: 10.1046/j.1365-3164.1997.d01-5.x It is the saying of Socrates, ‘I know that I know nothing’, that comes to mind when reading through our review article from 1997.1 We realize how limited our knowledge on the biology and pathology of the epidermis was at the time and how much it has evolved since then. In our review, we had focused on the epidermis as a structural membrane protecting inner homeostasis. We also knew and had emphasized how the keratinocyte that forms this structure undergoes a highly orchestrated process of proliferation and differentiation through differential expression of structural proteins, surface molecules and enzymes. In recent years, it has become evident that the epidermis is a complex multicellular organ, in which a sophisticated crosstalk between its cells, the environment and the body's metabolism takes place to ensure its many essential functions. While the air–liquid and the liquid–liquid barriers of the epidermis (Figure 1) form potent measures for separating the inside from the outside milieu, epidermal keratinocytes also have an immunostimulatory role to build up the defence system in co-operation with epidermal immune cells.2, 3 The epidermis is, however, not just a protective measure against harmful external influences and maintenance of the inner homeostasis but is also a true sensory organ of great importance for perception and transmission of environmental and internal signals including touch or electromagnetic stimulation. Since the mid-1990s, the collaborative work of cell biologists, dermatopathologists, geneticists and clinicians studying epidermal diseases at the University of Bern has contributed to expand the view of the epidermis in the dog (DermFocus; http://www.vetsuisse.unibe.ch/itpa/content/research/dermfocus/index_eng.html). New control mechanisms for the proliferation and differentiation process have emerged, including epigenetic regulation.5-7 Molecular alterations affecting barrier functions have been identified in dogs with atopic dermatitis,8, 9 including IgE levels and genetic signals associated with an antigen-specific IgE response in retriever breeds.10, 11 It has also become clear that the keratinocyte expresses a multitude of surface adhesion molecules that fulfil receptor functions transmitting signals into the cells and also going out, which is of relevance in the autoimmune disease pemphigus vulgaris in dogs and humans.12-16 Last but not least, the amazing capacity of the epidermis, but also of the hair follicle, to self-renew in a cyclical manner throughout the lifetime has revealed the presence of tissue stem cells.17 The study of the Bernese DermFocus collaborators in the dog, together with the recently defined cyclical hair follicle morphology,18 will have clinical implications for hair follicle disorders such as canine noninflammatory alopecia or ectodermal dysplasia.19-21 The capacity of epidermal keratinocytes for self-renewal has also provided the basis for establishing long-term keratinocyte cultures from mice and dogs, which initially contributed to the modelling and study of the proliferation and differentiation process in vitro,7, 22, 23 and will also provide a source of multipotent stem cells for future developments in regenerative medicine. The recently demonstrated self-organizing principle of tissue, which has been revealed through a specialized culture of embryonic and induced pluripotent stem cells,24 now provides the starting point for the next generation of regenerative medicine, which is expected to involve all organs and their tissue-resident stem cells, in particular the easily accessible skin and its appendages. Taken together, over the last two decades fantastic progress has been made in the understanding of keratinocyte biology and pathology, further revealing the great complexity and active role of the skin in balanced homeostasis. This makes us realize that we have truly analysed only the tip of the iceberg and that we still ‘know that we know nothing’. With the current understanding and today's available technologies, we are therefore looking forward to new exciting developments to be read in this journal for another 25 years." @default.
• W2057491036 created "2016-06-24" @default.
• W2057491036 creator A5010796876 @default.
• W2057491036 creator A5012088943 @default.
• W2057491036 creator A5022898522 @default.
• W2057491036 creator A5027612465 @default.
• W2057491036 creator A5029969915 @default.
• W2057491036 creator A5030471987 @default.
• W2057491036 creator A5032373411 @default.
• W2057491036 creator A5035242879 @default.
• W2057491036 creator A5084040078 @default.
• W2057491036 date "2014-08-01" @default.
• W2057491036 modified "2023-10-17" @default.
• W2057491036 title "Keratinocyte biology and pathology" @default.
• W2057491036 cites W1500611080 @default.
• W2057491036 cites W1522395468 @default.
• W2057491036 cites W1592946633 @default.
• W2057491036 cites W1596237853 @default.
• W2057491036 cites W1757534540 @default.
• W2057491036 cites W1836110191 @default.
• W2057491036 cites W1965507945 @default.
• W2057491036 cites W1976709348 @default.
• W2057491036 cites W2017209600 @default.
• W2057491036 cites W2020930305 @default.
• W2057491036 cites W2034446023 @default.
• W2057491036 cites W2038658651 @default.
• W2057491036 cites W2047177185 @default.
• W2057491036 cites W2057097356 @default.
• W2057491036 cites W2085397075 @default.
• W2057491036 cites W2094761598 @default.
• W2057491036 cites W2095435242 @default.
• W2057491036 cites W2099853794 @default.
• W2057491036 cites W2111724542 @default.
• W2057491036 cites W2157038335 @default.
• W2057491036 cites W2158755880 @default.
• W2057491036 cites W2161884171 @default.
• W2057491036 cites W2166069190 @default.
• W2057491036 cites W4236450410 @default.
• W2057491036 doi "https://doi.org/10.1111/vde.12158" @default.
• W2057491036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34645065" @default.
• W2057491036 hasPublicationYear "2014" @default.
• W2057491036 type Work @default.
• W2057491036 sameAs 2057491036 @default.
• W2057491036 citedByCount "12" @default.
• W2057491036 countsByYear W20574910362014 @default.
• W2057491036 countsByYear W20574910362018 @default.
• W2057491036 countsByYear W20574910362019 @default.
• W2057491036 crossrefType "journal-article" @default.
• W2057491036 hasAuthorship W2057491036A5010796876 @default.
• W2057491036 hasAuthorship W2057491036A5012088943 @default.
• W2057491036 hasAuthorship W2057491036A5022898522 @default.
• W2057491036 hasAuthorship W2057491036A5027612465 @default.
• W2057491036 hasAuthorship W2057491036A5029969915 @default.
• W2057491036 hasAuthorship W2057491036A5030471987 @default.
• W2057491036 hasAuthorship W2057491036A5032373411 @default.
• W2057491036 hasAuthorship W2057491036A5035242879 @default.
• W2057491036 hasAuthorship W2057491036A5084040078 @default.
• W2057491036 hasBestOaLocation W20574910361 @default.
• W2057491036 hasConcept C105702510 @default.
• W2057491036 hasConcept C111472728 @default.
• W2057491036 hasConcept C120665830 @default.
• W2057491036 hasConcept C121332964 @default.
• W2057491036 hasConcept C136815107 @default.
• W2057491036 hasConcept C138885662 @default.
• W2057491036 hasConcept C169822122 @default.
• W2057491036 hasConcept C202751555 @default.
• W2057491036 hasConcept C2776458125 @default.
• W2057491036 hasConcept C2777074287 @default.
• W2057491036 hasConcept C54355233 @default.
• W2057491036 hasConcept C86803240 @default.
• W2057491036 hasConcept C95444343 @default.
• W2057491036 hasConceptScore W2057491036C105702510 @default.
• W2057491036 hasConceptScore W2057491036C111472728 @default.
• W2057491036 hasConceptScore W2057491036C120665830 @default.
• W2057491036 hasConceptScore W2057491036C121332964 @default.
• W2057491036 hasConceptScore W2057491036C136815107 @default.
• W2057491036 hasConceptScore W2057491036C138885662 @default.
• W2057491036 hasConceptScore W2057491036C169822122 @default.
• W2057491036 hasConceptScore W2057491036C202751555 @default.
• W2057491036 hasConceptScore W2057491036C2776458125 @default.
• W2057491036 hasConceptScore W2057491036C2777074287 @default.
• W2057491036 hasConceptScore W2057491036C54355233 @default.
• W2057491036 hasConceptScore W2057491036C86803240 @default.
• W2057491036 hasConceptScore W2057491036C95444343 @default.
• W2057491036 hasIssue "4" @default.
• W2057491036 hasLocation W20574910361 @default.
• W2057491036 hasLocation W20574910362 @default.
• W2057491036 hasOpenAccess W2057491036 @default.
• W2057491036 hasPrimaryLocation W20574910361 @default.
• W2057491036 hasRelatedWork W2013884713 @default.
• W2057491036 hasRelatedWork W2021274172 @default.
• W2057491036 hasRelatedWork W2022674745 @default.
• W2057491036 hasRelatedWork W2030037941 @default.
• W2057491036 hasRelatedWork W2056438352 @default.
• W2057491036 hasRelatedWork W2107928168 @default.
• W2057491036 hasRelatedWork W2252557132 @default.
• W2057491036 hasRelatedWork W2515422232 @default.
• W2057491036 hasRelatedWork W4246243753 @default.

• next