FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057493003> ?p ?o ?g. }

• W2057493003 endingPage "734" @default.
• W2057493003 startingPage "724" @default.
• W2057493003 abstract "Abstract We have previously demonstrated induction of O ‐acetylated sialoglycoproteins on lymphoblasts of childhood acute lymphoblastic leukaemia (ALL). These molecules promote survival of lymphoblasts by preventing apoptosis. Although O ‐acetylated sialoglycoproteins are over expressed, the status of O ‐acetylation of gangliosides and their role in lymphoblasts survival remains to be explored in ALL patients. Here, we have observed enhanced levels of 9‐ O ‐acetylated GD3 (9‐ O ‐AcGD3) in the lymphoblasts of patients and leukaemic cell line versus disialoganglioside GD3 in comparison to the normal cells. Localization of GD3 and 9‐ O ‐AcGD3 on mitochondria of patient's lymphoblasts has been demonstrated by immuno‐electron microscopy. The exogenous administration of GD3‐induced apoptosis in lymphoblasts as evident from the nuclear fragmentation and sub G0/G1 apoptotic peak. In contrast, 9‐ O ‐AcGD3 failed to induce such apoptosis. We further explored the mitochondria‐dependent pathway triggered during GD3‐induced apoptosis in lymphoblasts. GD3 caused a time‐dependent depolarization of mitochondrial membrane potential, release of cytochrome c and 7.4‐ and 8‐fold increased in caspase 9 and caspase 3 activity respectively. However, under identical conditions, an equimolar concentration of 9‐ O ‐AcGD3 failed to induce similar effects. Interestingly, 9‐ O ‐AcGD3 protected the lymphoblasts from GD3‐induced apoptosis when administered in equimolar concentrations simultaneously. In situ de‐ O ‐acetylation of 9‐ O ‐AcGD3 with sodium salicylate restores the GD3‐responsiveness to apoptotic signals. Although both GD3 and 9‐ O ‐acetyl GD3 localize to mitochondria, these two structurally related molecules may play different roles in ALL‐disease biology. Taken together, our results suggest that O ‐acetylation of GD3, like that of O ‐acetylated sialoglycoproteins, might be a general strategy adopted by leukaemic blasts towards survival in ALL. J. Cell. Biochem. 105: 724–734, 2008. © 2008 Wiley‐Liss, Inc." @default.
• W2057493003 created "2016-06-24" @default.
• W2057493003 creator A5004894072 @default.
• W2057493003 creator A5013866231 @default.
• W2057493003 creator A5038236759 @default.
• W2057493003 creator A5044009240 @default.
• W2057493003 creator A5062398432 @default.
• W2057493003 creator A5072396626 @default.
• W2057493003 creator A5080932420 @default.
• W2057493003 date "2008-07-24" @default.
• W2057493003 modified "2023-10-17" @default.
• W2057493003 title "<i>O</i>‐acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia" @default.
• W2057493003 cites W1507204562 @default.
• W2057493003 cites W1560018980 @default.
• W2057493003 cites W1750381543 @default.
• W2057493003 cites W1798442613 @default.
• W2057493003 cites W1968112618 @default.
• W2057493003 cites W1972872139 @default.
• W2057493003 cites W1975499258 @default.
• W2057493003 cites W1988562845 @default.
• W2057493003 cites W1989767150 @default.
• W2057493003 cites W1996385344 @default.
• W2057493003 cites W2003950777 @default.
• W2057493003 cites W2004877384 @default.
• W2057493003 cites W2016573452 @default.
• W2057493003 cites W2021505229 @default.
• W2057493003 cites W2024191111 @default.
• W2057493003 cites W2027538502 @default.
• W2057493003 cites W2030597425 @default.
• W2057493003 cites W2036346288 @default.
• W2057493003 cites W2060245884 @default.
• W2057493003 cites W2063103774 @default.
• W2057493003 cites W2073590456 @default.
• W2057493003 cites W2078533126 @default.
• W2057493003 cites W2081086607 @default.
• W2057493003 cites W2099816756 @default.
• W2057493003 cites W2100644351 @default.
• W2057493003 cites W2104868583 @default.
• W2057493003 cites W2116850184 @default.
• W2057493003 cites W2118833105 @default.
• W2057493003 cites W2157086793 @default.
• W2057493003 cites W2159650080 @default.
• W2057493003 cites W2160942082 @default.
• W2057493003 cites W2166371391 @default.
• W2057493003 cites W2171751989 @default.
• W2057493003 cites W2175766170 @default.
• W2057493003 cites W67114676 @default.
• W2057493003 doi "https://doi.org/10.1002/jcb.21867" @default.
• W2057493003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18655184" @default.
• W2057493003 hasPublicationYear "2008" @default.
• W2057493003 type Work @default.
• W2057493003 sameAs 2057493003 @default.
• W2057493003 citedByCount "48" @default.
• W2057493003 countsByYear W20574930032012 @default.
• W2057493003 countsByYear W20574930032013 @default.
• W2057493003 countsByYear W20574930032014 @default.
• W2057493003 countsByYear W20574930032015 @default.
• W2057493003 countsByYear W20574930032017 @default.
• W2057493003 countsByYear W20574930032018 @default.
• W2057493003 countsByYear W20574930032019 @default.
• W2057493003 countsByYear W20574930032020 @default.
• W2057493003 countsByYear W20574930032021 @default.
• W2057493003 countsByYear W20574930032022 @default.
• W2057493003 countsByYear W20574930032023 @default.
• W2057493003 crossrefType "journal-article" @default.
• W2057493003 hasAuthorship W2057493003A5004894072 @default.
• W2057493003 hasAuthorship W2057493003A5013866231 @default.
• W2057493003 hasAuthorship W2057493003A5038236759 @default.
• W2057493003 hasAuthorship W2057493003A5044009240 @default.
• W2057493003 hasAuthorship W2057493003A5062398432 @default.
• W2057493003 hasAuthorship W2057493003A5072396626 @default.
• W2057493003 hasAuthorship W2057493003A5080932420 @default.
• W2057493003 hasBestOaLocation W20574930031 @default.
• W2057493003 hasConcept C104317684 @default.
• W2057493003 hasConcept C113842279 @default.
• W2057493003 hasConcept C119157956 @default.
• W2057493003 hasConcept C153911025 @default.
• W2057493003 hasConcept C185592680 @default.
• W2057493003 hasConcept C190283241 @default.
• W2057493003 hasConcept C28859421 @default.
• W2057493003 hasConcept C29311851 @default.
• W2057493003 hasConcept C54355233 @default.
• W2057493003 hasConcept C55493867 @default.
• W2057493003 hasConcept C81885089 @default.
• W2057493003 hasConcept C86803240 @default.
• W2057493003 hasConceptScore W2057493003C104317684 @default.
• W2057493003 hasConceptScore W2057493003C113842279 @default.
• W2057493003 hasConceptScore W2057493003C119157956 @default.
• W2057493003 hasConceptScore W2057493003C153911025 @default.
• W2057493003 hasConceptScore W2057493003C185592680 @default.
• W2057493003 hasConceptScore W2057493003C190283241 @default.
• W2057493003 hasConceptScore W2057493003C28859421 @default.
• W2057493003 hasConceptScore W2057493003C29311851 @default.
• W2057493003 hasConceptScore W2057493003C54355233 @default.
• W2057493003 hasConceptScore W2057493003C55493867 @default.
• W2057493003 hasConceptScore W2057493003C81885089 @default.
• W2057493003 hasConceptScore W2057493003C86803240 @default.
• W2057493003 hasIssue "3" @default.

• next