FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057505444> ?p ?o ?g. }

• W2057505444 endingPage "e1003248" @default.
• W2057505444 startingPage "e1003248" @default.
• W2057505444 abstract "The dominant phenotype of greying with age in horses, caused by a 4.6-kb duplication in intron 6 of STX17, is associated with a high incidence of melanoma and vitiligo-like skin depigmentation. However, the progressive greying and the incidence of melanoma, vitiligo-like depigmentation, and amount of speckling in these horses do not follow a simple inheritance pattern. To understand their inheritance, we analysed the melanoma grade, grey level, vitiligo grade, and speckling grade of 1,119 Grey horses (7,146 measurements) measured in six countries over a 9-year period. We estimated narrow sense heritability (h(2)), and we decomposed this parameter into polygenic heritability (h(2) (POLY)), heritability due to the Grey (STX17) mutation (h(2) (STX17)), and heritability due to agouti (ASIP) locus (h(2) (ASIP)). A high heritability was found for greying (h(2) = 0.79), vitiligo (h(2) = 0.63), and speckling (h(2) = 0.66), while a moderate heritability was estimated for melanoma (h(2) = 0.37). The additive component of ASIP was significantly different from zero only for melanoma (h(2) (ASIP) = 0.02). STX17 controlled large proportions of phenotypic variance (h(2) (STX17) = 0.18-0.55) and overall heritability (h(2) (STX17)/h(2) = 0.28-0.83) for all traits. Genetic correlations among traits were estimated as moderate to high, primarily due to the effects of the STX17 locus. Nevertheless, the correlation between progressive greying and vitiligo-like depigmentation remained large even after taking into account the effects of STX17. We presented a model where four traits with complex inheritance patterns are strongly influenced by a single mutation. This is in line with evidence of recent studies in domestic animals indicating that some complex traits are, in addition to the large number of genes with small additive effects, influenced by genes of moderate-to-large effect. Furthermore, we demonstrated that the STX17 mutation explains to a large extent the moderate to high genetic correlations among traits, providing an example of strong pleiotropic effects caused by a single gene." @default.
• W2057505444 created "2016-06-24" @default.
• W2057505444 creator A5006837188 @default.
• W2057505444 creator A5012967062 @default.
• W2057505444 creator A5015878392 @default.
• W2057505444 creator A5019209811 @default.
• W2057505444 creator A5041653609 @default.
• W2057505444 creator A5058411284 @default.
• W2057505444 creator A5082341333 @default.
• W2057505444 date "2013-02-07" @default.
• W2057505444 modified "2023-10-15" @default.
• W2057505444 title "Complex Inheritance of Melanoma and Pigmentation of Coat and Skin in Grey Horses" @default.
• W2057505444 cites W1525395376 @default.
• W2057505444 cites W1540326034 @default.
• W2057505444 cites W1542322508 @default.
• W2057505444 cites W1976074961 @default.
• W2057505444 cites W1981061436 @default.
• W2057505444 cites W1987333629 @default.
• W2057505444 cites W1989392531 @default.
• W2057505444 cites W2015960360 @default.
• W2057505444 cites W2023296558 @default.
• W2057505444 cites W2032631425 @default.
• W2057505444 cites W2045107415 @default.
• W2057505444 cites W2046247026 @default.
• W2057505444 cites W2062258558 @default.
• W2057505444 cites W2064497209 @default.
• W2057505444 cites W2075018325 @default.
• W2057505444 cites W2076033726 @default.
• W2057505444 cites W2077763475 @default.
• W2057505444 cites W2077946779 @default.
• W2057505444 cites W2080183225 @default.
• W2057505444 cites W2084922050 @default.
• W2057505444 cites W2094608127 @default.
• W2057505444 cites W2098381128 @default.
• W2057505444 cites W2100184629 @default.
• W2057505444 cites W2111174102 @default.
• W2057505444 cites W2116100197 @default.
• W2057505444 cites W2122855146 @default.
• W2057505444 cites W2123570137 @default.
• W2057505444 cites W2134475351 @default.
• W2057505444 cites W2148878566 @default.
• W2057505444 cites W2155496693 @default.
• W2057505444 cites W4234606450 @default.
• W2057505444 cites W4291746384 @default.
• W2057505444 cites W4300038072 @default.
• W2057505444 doi "https://doi.org/10.1371/journal.pgen.1003248" @default.
• W2057505444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3567150" @default.
• W2057505444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23408897" @default.
• W2057505444 hasPublicationYear "2013" @default.
• W2057505444 type Work @default.
• W2057505444 sameAs 2057505444 @default.
• W2057505444 citedByCount "44" @default.
• W2057505444 countsByYear W20575054442013 @default.
• W2057505444 countsByYear W20575054442014 @default.
• W2057505444 countsByYear W20575054442015 @default.
• W2057505444 countsByYear W20575054442016 @default.
• W2057505444 countsByYear W20575054442017 @default.
• W2057505444 countsByYear W20575054442018 @default.
• W2057505444 countsByYear W20575054442019 @default.
• W2057505444 countsByYear W20575054442020 @default.
• W2057505444 countsByYear W20575054442021 @default.
• W2057505444 countsByYear W20575054442022 @default.
• W2057505444 countsByYear W20575054442023 @default.
• W2057505444 crossrefType "journal-article" @default.
• W2057505444 hasAuthorship W2057505444A5006837188 @default.
• W2057505444 hasAuthorship W2057505444A5012967062 @default.
• W2057505444 hasAuthorship W2057505444A5015878392 @default.
• W2057505444 hasAuthorship W2057505444A5019209811 @default.
• W2057505444 hasAuthorship W2057505444A5041653609 @default.
• W2057505444 hasAuthorship W2057505444A5058411284 @default.
• W2057505444 hasAuthorship W2057505444A5082341333 @default.
• W2057505444 hasBestOaLocation W20575054441 @default.
• W2057505444 hasConcept C104317684 @default.
• W2057505444 hasConcept C161890455 @default.
• W2057505444 hasConcept C2776972258 @default.
• W2057505444 hasConcept C2777658100 @default.
• W2057505444 hasConcept C2779179668 @default.
• W2057505444 hasConcept C2779980618 @default.
• W2057505444 hasConcept C54355233 @default.
• W2057505444 hasConcept C84597430 @default.
• W2057505444 hasConcept C86803240 @default.
• W2057505444 hasConceptScore W2057505444C104317684 @default.
• W2057505444 hasConceptScore W2057505444C161890455 @default.
• W2057505444 hasConceptScore W2057505444C2776972258 @default.
• W2057505444 hasConceptScore W2057505444C2777658100 @default.
• W2057505444 hasConceptScore W2057505444C2779179668 @default.
• W2057505444 hasConceptScore W2057505444C2779980618 @default.
• W2057505444 hasConceptScore W2057505444C54355233 @default.
• W2057505444 hasConceptScore W2057505444C84597430 @default.
• W2057505444 hasConceptScore W2057505444C86803240 @default.
• W2057505444 hasIssue "2" @default.
• W2057505444 hasLocation W20575054441 @default.
• W2057505444 hasLocation W20575054442 @default.
• W2057505444 hasLocation W20575054443 @default.
• W2057505444 hasLocation W20575054444 @default.
• W2057505444 hasLocation W20575054445 @default.
• W2057505444 hasLocation W20575054446 @default.
• W2057505444 hasOpenAccess W2057505444 @default.

• next