FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057513932> ?p ?o ?g. }

• W2057513932 endingPage "1194" @default.
• W2057513932 startingPage "1186" @default.
• W2057513932 abstract "Viroporins are a group of viral proteins that participate in viral replication cycles, including modification of membrane permeability and promotion of viral release. Although biological data have been accumulated on viroporion-like proteins of other viruses belonging to family Flaviviridae, the viroporin activity and membrane topology of p7 protein from classical swine fever virus (CSFV), a member of the genus Pestivirus of the family Flaviviridae, are largely unknown. In this study, sequence analysis of the primary structure of p7 polypeptide demonstrates that p7 contains two putative transmembrane regions connected by a short hydrophilic segment. Expression of p7 protein in Escherichia coli leads to the permeabilization of bacterial cells to small molecules. The p7 protein also enhances the permeability of mammalian cells, increasing the intracellular Ca2+ concentration and the permeability of cells to the translation inhibitor Hygromycin B. This protein is an integral membrane protein and can form homo-oligomers. It mainly localizes to the ER at the early stage of the expression and can be transferred to the plasma membrane at the late stage of the expression. Detergent permeabilization assays confirmed that the p7 protein is a 2-pass transmembrane protein and its N and C termini are exposed to the ER lumen. Deletion analysis showed that amino acid residues 41–63 may be essential for the viroporin activity of the protein. Our studies demonstrate that CSFV p7 possesses properties commonly associated with viroporins, which could be a potential target for the development of a therapeutic intervention for classic swine fever virus infection." @default.
• W2057513932 created "2016-06-24" @default.
• W2057513932 creator A5003007062 @default.
• W2057513932 creator A5004111225 @default.
• W2057513932 creator A5025204478 @default.
• W2057513932 creator A5036907897 @default.
• W2057513932 creator A5054743463 @default.
• W2057513932 creator A5063917782 @default.
• W2057513932 creator A5068205683 @default.
• W2057513932 creator A5072480558 @default.
• W2057513932 creator A5080871383 @default.
• W2057513932 creator A5081183372 @default.
• W2057513932 creator A5085968117 @default.
• W2057513932 date "2013-07-01" @default.
• W2057513932 modified "2023-09-29" @default.
• W2057513932 title "Viroporin activity and membrane topology of classic swine fever virus p7 protein" @default.
• W2057513932 cites W1522612217 @default.
• W2057513932 cites W1572116252 @default.
• W2057513932 cites W1873199501 @default.
• W2057513932 cites W1970007744 @default.
• W2057513932 cites W1971542798 @default.
• W2057513932 cites W1976172896 @default.
• W2057513932 cites W1981976252 @default.
• W2057513932 cites W1986002459 @default.
• W2057513932 cites W1986363766 @default.
• W2057513932 cites W1992496728 @default.
• W2057513932 cites W1998941663 @default.
• W2057513932 cites W2018577190 @default.
• W2057513932 cites W2026469956 @default.
• W2057513932 cites W2030441312 @default.
• W2057513932 cites W2030576960 @default.
• W2057513932 cites W2032457529 @default.
• W2057513932 cites W2034453538 @default.
• W2057513932 cites W2047248494 @default.
• W2057513932 cites W2050997685 @default.
• W2057513932 cites W2051553690 @default.
• W2057513932 cites W2057040842 @default.
• W2057513932 cites W2057654310 @default.
• W2057513932 cites W2065803841 @default.
• W2057513932 cites W2071136569 @default.
• W2057513932 cites W2086837310 @default.
• W2057513932 cites W2090015428 @default.
• W2057513932 cites W2126616839 @default.
• W2057513932 cites W2127398998 @default.
• W2057513932 cites W2130963764 @default.
• W2057513932 cites W2133249965 @default.
• W2057513932 cites W2136900614 @default.
• W2057513932 cites W2151320496 @default.
• W2057513932 cites W2151581088 @default.
• W2057513932 cites W2157073047 @default.
• W2057513932 cites W2161003987 @default.
• W2057513932 cites W2162164602 @default.
• W2057513932 cites W2162316896 @default.
• W2057513932 cites W2171583504 @default.
• W2057513932 cites W2889064246 @default.
• W2057513932 cites W91404106 @default.
• W2057513932 doi "https://doi.org/10.1016/j.biocel.2013.03.021" @default.
• W2057513932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23583663" @default.
• W2057513932 hasPublicationYear "2013" @default.
• W2057513932 type Work @default.
• W2057513932 sameAs 2057513932 @default.
• W2057513932 citedByCount "17" @default.
• W2057513932 countsByYear W20575139322013 @default.
• W2057513932 countsByYear W20575139322014 @default.
• W2057513932 countsByYear W20575139322015 @default.
• W2057513932 countsByYear W20575139322016 @default.
• W2057513932 countsByYear W20575139322017 @default.
• W2057513932 countsByYear W20575139322018 @default.
• W2057513932 countsByYear W20575139322021 @default.
• W2057513932 countsByYear W20575139322022 @default.
• W2057513932 countsByYear W20575139322023 @default.
• W2057513932 crossrefType "journal-article" @default.
• W2057513932 hasAuthorship W2057513932A5003007062 @default.
• W2057513932 hasAuthorship W2057513932A5004111225 @default.
• W2057513932 hasAuthorship W2057513932A5025204478 @default.
• W2057513932 hasAuthorship W2057513932A5036907897 @default.
• W2057513932 hasAuthorship W2057513932A5054743463 @default.
• W2057513932 hasAuthorship W2057513932A5063917782 @default.
• W2057513932 hasAuthorship W2057513932A5068205683 @default.
• W2057513932 hasAuthorship W2057513932A5072480558 @default.
• W2057513932 hasAuthorship W2057513932A5080871383 @default.
• W2057513932 hasAuthorship W2057513932A5081183372 @default.
• W2057513932 hasAuthorship W2057513932A5085968117 @default.
• W2057513932 hasConcept C104317684 @default.
• W2057513932 hasConcept C118892022 @default.
• W2057513932 hasConcept C144647389 @default.
• W2057513932 hasConcept C146033667 @default.
• W2057513932 hasConcept C153911025 @default.
• W2057513932 hasConcept C159047783 @default.
• W2057513932 hasConcept C161200384 @default.
• W2057513932 hasConcept C167625842 @default.
• W2057513932 hasConcept C170493617 @default.
• W2057513932 hasConcept C24530287 @default.
• W2057513932 hasConcept C2522874641 @default.
• W2057513932 hasConcept C2776408679 @default.
• W2057513932 hasConcept C2777510210 @default.
• W2057513932 hasConcept C41625074 @default.
• W2057513932 hasConcept C515207424 @default.

• next