FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057515730> ?p ?o ?g. }

• W2057515730 abstract "Inflammatory and matrix degrading gene variants have been reported to be associated with disc degeneration. Some of these variants also modulate peripheral pain. This study examines the association of these genetic variants with radiographic lumbar disc degeneration and changes in pain and disability at long-term after surgical and cognitive behavioural management.93 unrelated patients with chronic low back pain (CLBP) for duration of >1 year and lumbar disc degeneration were treated with lumbar fusion or cognitive intervention and exercises. Standardised questionnaires included the Oswestry Disability Index (ODI) and Visual Analog Score (VAS) for CLBP, were filled in by patients both at baseline and at 9 years follow-up. Degenerative changes at baseline Magnetic Resonance Imaging and Computed Tomography scans, were graded as moderate and severe (N=79). Yield and quality of blood and saliva DNA was assessed by nano drop spectrophotometry. Eight SNPs in 5 inflammatory and matrix degrading genes were successfully genotyped. Single marker and haplotype association with severity of degeneration, number of discs involved, changes in ODI and VAS CLBP, was done using Haploview, linear regression and R-package Haplostats.Association analysis of individual SNPs revealed association of IL18RAP polymorphism rs1420100 with severe degeneration (p = 0.05) and more than one degenerated disc (p = 0.02). From the same gene two SNPs, rs917997 and rs1420106, were found to be in strong linkage disequilibrium (LD) and were associated with post treatment improvement in disability (p = 0.02). Haplotype association analysis of 5 SNPs spanning across IL18RAP, IL18R1 and IL1A genes revealed significant associations with improvement in disability (p=0.02) and reduction in pain (p=0.04). An association was found between MMP3 polymorphism rs72520913 and improvement in pain (p = 0.03) and with severe degeneration (p = 0.006).The findings of the current study suggest a role of variation at inflammatory and matrix degrading genes with severity of lumbar disc degeneration, pain and disability." @default.
• W2057515730 created "2016-06-24" @default.
• W2057515730 creator A5006191973 @default.
• W2057515730 creator A5047037920 @default.
• W2057515730 creator A5049463864 @default.
• W2057515730 creator A5061808744 @default.
• W2057515730 creator A5087797189 @default.
• W2057515730 date "2013-03-22" @default.
• W2057515730 modified "2023-10-07" @default.
• W2057515730 title "Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study" @default.
• W2057515730 cites W1505597474 @default.
• W2057515730 cites W1571519341 @default.
• W2057515730 cites W1973067272 @default.
• W2057515730 cites W1976429655 @default.
• W2057515730 cites W1977849332 @default.
• W2057515730 cites W1984452463 @default.
• W2057515730 cites W1992161057 @default.
• W2057515730 cites W2011210741 @default.
• W2057515730 cites W2013713556 @default.
• W2057515730 cites W2015458109 @default.
• W2057515730 cites W2017037741 @default.
• W2057515730 cites W2022167882 @default.
• W2057515730 cites W2036031728 @default.
• W2057515730 cites W2036144540 @default.
• W2057515730 cites W2037352042 @default.
• W2057515730 cites W2039176395 @default.
• W2057515730 cites W2051577657 @default.
• W2057515730 cites W2055656298 @default.
• W2057515730 cites W2058417962 @default.
• W2057515730 cites W2060870043 @default.
• W2057515730 cites W2065391130 @default.
• W2057515730 cites W2070685370 @default.
• W2057515730 cites W2076104953 @default.
• W2057515730 cites W2082683336 @default.
• W2057515730 cites W2087050793 @default.
• W2057515730 cites W2089860017 @default.
• W2057515730 cites W2090430326 @default.
• W2057515730 cites W2104297616 @default.
• W2057515730 cites W2110689133 @default.
• W2057515730 cites W2110769281 @default.
• W2057515730 cites W2111158761 @default.
• W2057515730 cites W2111209536 @default.
• W2057515730 cites W2112060315 @default.
• W2057515730 cites W2115805888 @default.
• W2057515730 cites W2118094114 @default.
• W2057515730 cites W2148905883 @default.
• W2057515730 cites W2150271931 @default.
• W2057515730 cites W2153458404 @default.
• W2057515730 cites W2153712024 @default.
• W2057515730 cites W2162530578 @default.
• W2057515730 cites W2163190968 @default.
• W2057515730 cites W2166180635 @default.
• W2057515730 cites W2170187345 @default.
• W2057515730 cites W2326211238 @default.
• W2057515730 cites W4252839768 @default.
• W2057515730 cites W82618136 @default.
• W2057515730 cites W94629406 @default.
• W2057515730 doi "https://doi.org/10.1186/1471-2474-14-105" @default.
• W2057515730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3610293" @default.
• W2057515730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23522322" @default.
• W2057515730 hasPublicationYear "2013" @default.
• W2057515730 type Work @default.
• W2057515730 sameAs 2057515730 @default.
• W2057515730 citedByCount "47" @default.
• W2057515730 countsByYear W20575157302013 @default.
• W2057515730 countsByYear W20575157302014 @default.
• W2057515730 countsByYear W20575157302015 @default.
• W2057515730 countsByYear W20575157302016 @default.
• W2057515730 countsByYear W20575157302017 @default.
• W2057515730 countsByYear W20575157302018 @default.
• W2057515730 countsByYear W20575157302019 @default.
• W2057515730 countsByYear W20575157302020 @default.
• W2057515730 countsByYear W20575157302021 @default.
• W2057515730 countsByYear W20575157302022 @default.
• W2057515730 countsByYear W20575157302023 @default.
• W2057515730 crossrefType "journal-article" @default.
• W2057515730 hasAuthorship W2057515730A5006191973 @default.
• W2057515730 hasAuthorship W2057515730A5047037920 @default.
• W2057515730 hasAuthorship W2057515730A5049463864 @default.
• W2057515730 hasAuthorship W2057515730A5061808744 @default.
• W2057515730 hasAuthorship W2057515730A5087797189 @default.
• W2057515730 hasBestOaLocation W20575157301 @default.
• W2057515730 hasConcept C104317684 @default.
• W2057515730 hasConcept C126322002 @default.
• W2057515730 hasConcept C135763542 @default.
• W2057515730 hasConcept C141071460 @default.
• W2057515730 hasConcept C142724271 @default.
• W2057515730 hasConcept C153209595 @default.
• W2057515730 hasConcept C197754878 @default.
• W2057515730 hasConcept C204787440 @default.
• W2057515730 hasConcept C2775998654 @default.
• W2057515730 hasConcept C2780907711 @default.
• W2057515730 hasConcept C44575665 @default.
• W2057515730 hasConcept C54355233 @default.
• W2057515730 hasConcept C71924100 @default.
• W2057515730 hasConcept C86803240 @default.
• W2057515730 hasConceptScore W2057515730C104317684 @default.
• W2057515730 hasConceptScore W2057515730C126322002 @default.
• W2057515730 hasConceptScore W2057515730C135763542 @default.
• W2057515730 hasConceptScore W2057515730C141071460 @default.

• next