Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057529668> ?p ?o ?g. }
- W2057529668 endingPage "33" @default.
- W2057529668 startingPage "25" @default.
- W2057529668 abstract "Objectives: A prospective multicenter validation of the ability of 1H magnetic resonance spectroscopic imaging (MRSI) to distinguish cancer from noncancer tissues throughout the prostate with histopathology of the resected organ as the standard of reference. Materials and Methods: Institutional review board approval was obtained for all centers and all participating patients and volunteers provided written informed consent. Ninety-nine patients and 10 age-matched volunteers from 8 participating centers underwent magnetic resonance imaging and 3-dimensional MRSI with an endorectal coil at 1.5 T. Selected MRSI voxels were assigned to the peripheral zone (PZ), the central gland (CG), the periurethral area, and cancer tissue. Signal ratios of choline + creatine to citrate (CC/C) in spectra of these voxels were automatically calculated. Receiver operating characteristic curves were constructed to assess the accuracy by which this ratio can discriminate cancer from noncancer tissue. Results: A total of 70% of voxels in noncancer tissue and 90% of voxels in cancer tissue passed the quality check of the automatically fitted spectra. The median CC/C was significantly different between any noncancer and cancer tissue (P < 0.0001), but not between the different contributing centers. CC/C increased with cancer focus size (P = 0.0008) and certainty of voxel mapping to histopathologic cancer site (P < 0.0001). The area under the receiver operating characteristic curve for discriminating voxels of cancer tissue from noncancer tissue was 0.88 (confidence interval: 0.84–0.92) in the PZ and 0.76 (confidence interval: 0.71–0.81) in the CG. Conclusions: In patients with prostate cancer, recruited from different institutions, 3-dimensional MRSI is demonstrated to be a robust and quantitative technique, producing significantly different CC/C values for cancer compared with noncancer tissue for both the CG and the PZ." @default.
- W2057529668 created "2016-06-24" @default.
- W2057529668 creator A5007857971 @default.
- W2057529668 creator A5022238327 @default.
- W2057529668 creator A5024003056 @default.
- W2057529668 creator A5028330050 @default.
- W2057529668 creator A5036947621 @default.
- W2057529668 creator A5039375311 @default.
- W2057529668 creator A5041771868 @default.
- W2057529668 creator A5044344644 @default.
- W2057529668 creator A5047591121 @default.
- W2057529668 creator A5055132173 @default.
- W2057529668 creator A5070879815 @default.
- W2057529668 creator A5075830569 @default.
- W2057529668 creator A5077895949 @default.
- W2057529668 date "2011-01-01" @default.
- W2057529668 modified "2023-10-17" @default.
- W2057529668 title "Discriminating Cancer From Noncancer Tissue in the Prostate by 3-Dimensional Proton Magnetic Resonance Spectroscopic Imaging" @default.
- W2057529668 cites W1980245127 @default.
- W2057529668 cites W1982501253 @default.
- W2057529668 cites W1987778129 @default.
- W2057529668 cites W1997698962 @default.
- W2057529668 cites W2005036258 @default.
- W2057529668 cites W2008875502 @default.
- W2057529668 cites W2012531224 @default.
- W2057529668 cites W2025385827 @default.
- W2057529668 cites W2026361718 @default.
- W2057529668 cites W2027022600 @default.
- W2057529668 cites W2038743811 @default.
- W2057529668 cites W2052070249 @default.
- W2057529668 cites W2055338605 @default.
- W2057529668 cites W2089420278 @default.
- W2057529668 cites W2097792258 @default.
- W2057529668 cites W2101153915 @default.
- W2057529668 cites W2101995865 @default.
- W2057529668 cites W2102577568 @default.
- W2057529668 cites W2108638403 @default.
- W2057529668 cites W2110394359 @default.
- W2057529668 cites W2118625479 @default.
- W2057529668 cites W2119973007 @default.
- W2057529668 cites W2130638610 @default.
- W2057529668 cites W2131307822 @default.
- W2057529668 cites W2133094593 @default.
- W2057529668 cites W2153280365 @default.
- W2057529668 cites W2155291764 @default.
- W2057529668 cites W2160757395 @default.
- W2057529668 cites W2163634187 @default.
- W2057529668 cites W2164051596 @default.
- W2057529668 cites W2164194457 @default.
- W2057529668 cites W4211024301 @default.
- W2057529668 doi "https://doi.org/10.1097/rli.0b013e3181f54081" @default.
- W2057529668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21188832" @default.
- W2057529668 hasPublicationYear "2011" @default.
- W2057529668 type Work @default.
- W2057529668 sameAs 2057529668 @default.
- W2057529668 citedByCount "69" @default.
- W2057529668 countsByYear W20575296682012 @default.
- W2057529668 countsByYear W20575296682013 @default.
- W2057529668 countsByYear W20575296682014 @default.
- W2057529668 countsByYear W20575296682015 @default.
- W2057529668 countsByYear W20575296682016 @default.
- W2057529668 countsByYear W20575296682017 @default.
- W2057529668 countsByYear W20575296682018 @default.
- W2057529668 countsByYear W20575296682019 @default.
- W2057529668 countsByYear W20575296682020 @default.
- W2057529668 countsByYear W20575296682021 @default.
- W2057529668 countsByYear W20575296682022 @default.
- W2057529668 countsByYear W20575296682023 @default.
- W2057529668 crossrefType "journal-article" @default.
- W2057529668 hasAuthorship W2057529668A5007857971 @default.
- W2057529668 hasAuthorship W2057529668A5022238327 @default.
- W2057529668 hasAuthorship W2057529668A5024003056 @default.
- W2057529668 hasAuthorship W2057529668A5028330050 @default.
- W2057529668 hasAuthorship W2057529668A5036947621 @default.
- W2057529668 hasAuthorship W2057529668A5039375311 @default.
- W2057529668 hasAuthorship W2057529668A5041771868 @default.
- W2057529668 hasAuthorship W2057529668A5044344644 @default.
- W2057529668 hasAuthorship W2057529668A5047591121 @default.
- W2057529668 hasAuthorship W2057529668A5055132173 @default.
- W2057529668 hasAuthorship W2057529668A5070879815 @default.
- W2057529668 hasAuthorship W2057529668A5075830569 @default.
- W2057529668 hasAuthorship W2057529668A5077895949 @default.
- W2057529668 hasConcept C121608353 @default.
- W2057529668 hasConcept C126322002 @default.
- W2057529668 hasConcept C126838900 @default.
- W2057529668 hasConcept C143409427 @default.
- W2057529668 hasConcept C2776235491 @default.
- W2057529668 hasConcept C2779896295 @default.
- W2057529668 hasConcept C2780192828 @default.
- W2057529668 hasConcept C2989005 @default.
- W2057529668 hasConcept C44249647 @default.
- W2057529668 hasConcept C530470458 @default.
- W2057529668 hasConcept C54170458 @default.
- W2057529668 hasConcept C58471807 @default.
- W2057529668 hasConcept C71924100 @default.
- W2057529668 hasConcept C96781048 @default.
- W2057529668 hasConceptScore W2057529668C121608353 @default.
- W2057529668 hasConceptScore W2057529668C126322002 @default.