Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057538939> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2057538939 endingPage "150" @default.
- W2057538939 startingPage "147" @default.
- W2057538939 abstract "TNF-related apoptosis-inducing ligand (TRAIL) is a peptide that inducesapoptosis to varying degrees in tumor cells, but not in normal cells. While TRAILsensitivity in tumors has been linked to c-myc- and MEK/Erk-induced enhancement ofcaspase activation, our recent study identified a third input controlling TRAIL sensitivity,namely the Akt-mTOR pathway. We showed that instead of enhancing TRAILsensitivity, Akt expression, acting through mTOR and the mTOR targets S6 kinase andeIF-4E, selectively enhances translation of the anti-apoptotic protein FLIPs and confersTRAIL resistance. In this perspective article we will discuss the linkage of the AktmTORpathway to other regulators of TRAIL sensitivity, its importance in controlling abroader range of apoptotic events, its utility in predicting TRAIL responsiveness, and itspotential manipulation for therapeutic benefit." @default.
- W2057538939 created "2016-06-24" @default.
- W2057538939 creator A5009633669 @default.
- W2057538939 creator A5063151134 @default.
- W2057538939 creator A5090727974 @default.
- W2057538939 date "2005-12-14" @default.
- W2057538939 modified "2023-10-10" @default.
- W2057538939 title "Translational Regulation of TRAIL Sensitivity" @default.
- W2057538939 doi "https://doi.org/10.4161/cc.5.2.2359" @default.
- W2057538939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16397410" @default.
- W2057538939 hasPublicationYear "2005" @default.
- W2057538939 type Work @default.
- W2057538939 sameAs 2057538939 @default.
- W2057538939 citedByCount "17" @default.
- W2057538939 countsByYear W20575389392012 @default.
- W2057538939 countsByYear W20575389392013 @default.
- W2057538939 countsByYear W20575389392015 @default.
- W2057538939 countsByYear W20575389392016 @default.
- W2057538939 countsByYear W20575389392019 @default.
- W2057538939 countsByYear W20575389392022 @default.
- W2057538939 crossrefType "journal-article" @default.
- W2057538939 hasAuthorship W2057538939A5009633669 @default.
- W2057538939 hasAuthorship W2057538939A5063151134 @default.
- W2057538939 hasAuthorship W2057538939A5090727974 @default.
- W2057538939 hasBestOaLocation W20575389391 @default.
- W2057538939 hasConcept C104317684 @default.
- W2057538939 hasConcept C105580179 @default.
- W2057538939 hasConcept C11960822 @default.
- W2057538939 hasConcept C149364088 @default.
- W2057538939 hasConcept C184235292 @default.
- W2057538939 hasConcept C190283241 @default.
- W2057538939 hasConcept C502942594 @default.
- W2057538939 hasConcept C54355233 @default.
- W2057538939 hasConcept C57074206 @default.
- W2057538939 hasConcept C62478195 @default.
- W2057538939 hasConcept C75217442 @default.
- W2057538939 hasConcept C86554907 @default.
- W2057538939 hasConcept C86803240 @default.
- W2057538939 hasConcept C95444343 @default.
- W2057538939 hasConceptScore W2057538939C104317684 @default.
- W2057538939 hasConceptScore W2057538939C105580179 @default.
- W2057538939 hasConceptScore W2057538939C11960822 @default.
- W2057538939 hasConceptScore W2057538939C149364088 @default.
- W2057538939 hasConceptScore W2057538939C184235292 @default.
- W2057538939 hasConceptScore W2057538939C190283241 @default.
- W2057538939 hasConceptScore W2057538939C502942594 @default.
- W2057538939 hasConceptScore W2057538939C54355233 @default.
- W2057538939 hasConceptScore W2057538939C57074206 @default.
- W2057538939 hasConceptScore W2057538939C62478195 @default.
- W2057538939 hasConceptScore W2057538939C75217442 @default.
- W2057538939 hasConceptScore W2057538939C86554907 @default.
- W2057538939 hasConceptScore W2057538939C86803240 @default.
- W2057538939 hasConceptScore W2057538939C95444343 @default.
- W2057538939 hasIssue "2" @default.
- W2057538939 hasLocation W20575389391 @default.
- W2057538939 hasLocation W20575389392 @default.
- W2057538939 hasOpenAccess W2057538939 @default.
- W2057538939 hasPrimaryLocation W20575389391 @default.
- W2057538939 hasRelatedWork W2024933597 @default.
- W2057538939 hasRelatedWork W2070783513 @default.
- W2057538939 hasRelatedWork W2098584395 @default.
- W2057538939 hasRelatedWork W2422815049 @default.
- W2057538939 hasRelatedWork W2916964185 @default.
- W2057538939 hasRelatedWork W2982360817 @default.
- W2057538939 hasRelatedWork W3116479654 @default.
- W2057538939 hasRelatedWork W3183179750 @default.
- W2057538939 hasRelatedWork W4205189596 @default.
- W2057538939 hasRelatedWork W4206939639 @default.
- W2057538939 hasVolume "5" @default.
- W2057538939 isParatext "false" @default.
- W2057538939 isRetracted "false" @default.
- W2057538939 magId "2057538939" @default.
- W2057538939 workType "article" @default.