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• W2057569198 abstract "Elucidation of molecular mechanisms that regulate synapse formation is required for the understanding of neural wiring, higher brain functions, and mental disorders. Despite the wealth of in vitro information, fundamental questions about how glutamatergic synapses are formed in the mammalian brain remain unanswered. Glutamate receptor (GluR) δ2 is essential for cerebellar synapse formation in vivo. Here, we show that the N-terminal domain (NTD) of GluRδ2 interacts with presynaptic neurexins (NRXNs) through cerebellin 1 precursor protein (Cbln1). The synaptogenic activity of GluRδ2 is abolished in cerebellar primary cultures from Cbln1 knockout mice and is restored by recombinant Cbln1. Knockdown of NRXNs in cerebellar granule cells also hinders the synaptogenic activity of GluRδ2. Both the NTD of GluRδ2 and the extracellular domain of NRXN1β suppressed the synaptogenic activity of Cbln1 in cerebellar primary cultures and in vivo. These results suggest that GluRδ2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1." @default.
• W2057569198 created "2016-06-24" @default.
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• W2057569198 date "2010-06-01" @default.
• W2057569198 modified "2023-10-11" @default.
• W2057569198 title "Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum" @default.
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• W2057569198 cites W1979236238 @default.
• W2057569198 cites W1988011192 @default.
• W2057569198 cites W1988012148 @default.
• W2057569198 cites W1990122129 @default.
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• W2057569198 doi "https://doi.org/10.1016/j.cell.2010.04.035" @default.
• W2057569198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20537373" @default.
• W2057569198 hasPublicationYear "2010" @default.
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