FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057573750> ?p ?o ?g. }

• W2057573750 endingPage "1195" @default.
• W2057573750 startingPage "1187" @default.
• W2057573750 abstract "Some new complexes of meclofenamic acid (N-(2,6-dichloro-m-tolyl)anthranilic acid), Hmeclo (1), with potentially interesting biological activities are described. Complexes [Mn(meclo)2] (2), [Cu(meclo)2(H2O)2] (3), [Zn(meclo)2(H2O)2] (4) and [Cd(meclo)2(H2O)2] (5) were prepared and structurally characterized by means of vibrational, electronic and 1H and 13C NMR spectroscopies. The crystal structure of complexes [Cu4(meclo)6(OH)2(DMSO)2]2DMSO (3a) and [Cd(meclo)2(DMSO)3] (5a) have been determined by X-ray crystallography. Complex (3a) is a centrosymmetric tetramer built up around the planar cyclic Cu2(OH)2 unit. Complex 5a is mononuclear seven-coordinated complex with the meclofenamato ligand behaving as a bidentate deprotonated chelating ligand. Intra and intermolecular hydrogen bonds stabilize these two structures, while the crystal packing is determined by π–π and C−H−–π interactions. Meclofenamic acid and its metal complexes have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines, MCF-7 (breast cancer cell line), T24 (bladder cancer cell line), and A-549 (non-small cell lung carcinoma), and a mouse fibroblast L-929 cell line. Complex 5 exhibits the highest selectivity against MCF-7 and 4 shows the highest selectivity against T-24. Complexes 2–5 were found to be more potent cytotoxic agents against T-24 and complex 5 against MCF-7 cancer cell lines than the prevalent benchmark metallodrug, cis-platin. The superoxide dismutase activity was measured by the Fridovich test which showed that complex [Cu(meclo)2(H2O)2] is a good superoxide scavenger." @default.
• W2057573750 created "2016-06-24" @default.
• W2057573750 creator A5001503075 @default.
• W2057573750 creator A5003716046 @default.
• W2057573750 creator A5021830601 @default.
• W2057573750 creator A5029165570 @default.
• W2057573750 creator A5058967207 @default.
• W2057573750 date "2011-09-01" @default.
• W2057573750 modified "2023-09-26" @default.
• W2057573750 title "Synthesis, crystal structures and spectroscopy of meclofenamic acid and its metal complexes with manganese(II), copper(II), zinc(II) and cadmium(II). Antiproliferative and superoxide dismutase activity" @default.
• W2057573750 cites W1965046216 @default.
• W2057573750 cites W1969460471 @default.
• W2057573750 cites W1970645517 @default.
• W2057573750 cites W1972016476 @default.
• W2057573750 cites W1974854333 @default.
• W2057573750 cites W1981354055 @default.
• W2057573750 cites W1983339783 @default.
• W2057573750 cites W1996039689 @default.
• W2057573750 cites W2005666472 @default.
• W2057573750 cites W2009688381 @default.
• W2057573750 cites W2012003693 @default.
• W2057573750 cites W2045084637 @default.
• W2057573750 cites W2061607741 @default.
• W2057573750 cites W2063934982 @default.
• W2057573750 cites W2066092661 @default.
• W2057573750 cites W2069926129 @default.
• W2057573750 cites W2070621112 @default.
• W2057573750 cites W2075634293 @default.
• W2057573750 cites W2088374639 @default.
• W2057573750 cites W2101422765 @default.
• W2057573750 cites W2101861123 @default.
• W2057573750 cites W2105249240 @default.
• W2057573750 cites W2109689528 @default.
• W2057573750 cites W2123344442 @default.
• W2057573750 cites W2131350133 @default.
• W2057573750 cites W2149083834 @default.
• W2057573750 cites W2167148961 @default.
• W2057573750 cites W22981103 @default.
• W2057573750 cites W2951747702 @default.
• W2057573750 cites W2993846082 @default.
• W2057573750 doi "https://doi.org/10.1016/j.jinorgbio.2011.05.025" @default.
• W2057573750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21718655" @default.
• W2057573750 hasPublicationYear "2011" @default.
• W2057573750 type Work @default.
• W2057573750 sameAs 2057573750 @default.
• W2057573750 citedByCount "69" @default.
• W2057573750 countsByYear W20575737502012 @default.
• W2057573750 countsByYear W20575737502013 @default.
• W2057573750 countsByYear W20575737502014 @default.
• W2057573750 countsByYear W20575737502015 @default.
• W2057573750 countsByYear W20575737502016 @default.
• W2057573750 countsByYear W20575737502017 @default.
• W2057573750 countsByYear W20575737502018 @default.
• W2057573750 countsByYear W20575737502019 @default.
• W2057573750 countsByYear W20575737502020 @default.
• W2057573750 countsByYear W20575737502021 @default.
• W2057573750 countsByYear W20575737502022 @default.
• W2057573750 countsByYear W20575737502023 @default.
• W2057573750 crossrefType "journal-article" @default.
• W2057573750 hasAuthorship W2057573750A5001503075 @default.
• W2057573750 hasAuthorship W2057573750A5003716046 @default.
• W2057573750 hasAuthorship W2057573750A5021830601 @default.
• W2057573750 hasAuthorship W2057573750A5029165570 @default.
• W2057573750 hasAuthorship W2057573750A5058967207 @default.
• W2057573750 hasConcept C109541995 @default.
• W2057573750 hasConcept C115624301 @default.
• W2057573750 hasConcept C116569031 @default.
• W2057573750 hasConcept C118629725 @default.
• W2057573750 hasConcept C121608353 @default.
• W2057573750 hasConcept C126322002 @default.
• W2057573750 hasConcept C145148216 @default.
• W2057573750 hasConcept C170493617 @default.
• W2057573750 hasConcept C178516000 @default.
• W2057573750 hasConcept C178790620 @default.
• W2057573750 hasConcept C181199279 @default.
• W2057573750 hasConcept C185592680 @default.
• W2057573750 hasConcept C2775838275 @default.
• W2057573750 hasConcept C2778886173 @default.
• W2057573750 hasConcept C2994423619 @default.
• W2057573750 hasConcept C55493867 @default.
• W2057573750 hasConcept C71240020 @default.
• W2057573750 hasConcept C71924100 @default.
• W2057573750 hasConcept C8010536 @default.
• W2057573750 hasConcept C96232424 @default.
• W2057573750 hasConceptScore W2057573750C109541995 @default.
• W2057573750 hasConceptScore W2057573750C115624301 @default.
• W2057573750 hasConceptScore W2057573750C116569031 @default.
• W2057573750 hasConceptScore W2057573750C118629725 @default.
• W2057573750 hasConceptScore W2057573750C121608353 @default.
• W2057573750 hasConceptScore W2057573750C126322002 @default.
• W2057573750 hasConceptScore W2057573750C145148216 @default.
• W2057573750 hasConceptScore W2057573750C170493617 @default.
• W2057573750 hasConceptScore W2057573750C178516000 @default.
• W2057573750 hasConceptScore W2057573750C178790620 @default.
• W2057573750 hasConceptScore W2057573750C181199279 @default.
• W2057573750 hasConceptScore W2057573750C185592680 @default.
• W2057573750 hasConceptScore W2057573750C2775838275 @default.
• W2057573750 hasConceptScore W2057573750C2778886173 @default.

• next