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- W2057582834 abstract "T. T. Puck has introduced and used the collection function for the study of a cellular population growing exponentially in vitro and then subjected to colcemide block. A rigorous derivation of his results is given in an earlier paper (Trucco, 1965c), but only for the case of equivivancy. (This means that the duration of a phase (G1, S, G2 or M) is the same for every cell in the population.) The present note deals with the case in which the distributions of sojourn times in each phase are characterized by probability density functions that depend only on cellular age. Using the age density functions, the following quantities can be computed: N(t), the total number of cells in the population as a function of time, and N(m)(t), the number of cells that are in mitosis. Furthermore, if tritiated thymidine is added to the culture as well as colcemide, expressions are derived for the number of labeled cells, L(t), and for the number of labeled mitoses, L(m)(t). In the case of equivivancy the results of this paper coincide with those obtained previously." @default.
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- W2057582834 date "1967-05-01" @default.
- W2057582834 modified "2023-10-16" @default.
- W2057582834 title "Collection functions for non-equivivant cell populations" @default.
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- W2057582834 doi "https://doi.org/10.1016/0022-5193(67)90199-3" @default.
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