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- W2057588369 abstract "Identification of an invasion-predictive biomarker that identifies oral epithelial dysplasia (OED) lesions with a high transformation potential could have clinical implications by helping to target chemoprevention. Insulin-like growth factor II mRNA–binding protein 3 (IMP3), which is a recently identified oncofetal protein essential for mRNA binding, trafficking, and stabilization, is overexpressed in many cancers, including oral squamous cell carcinoma (OSCC). Clinical studies have shown that IMP3 expression in biopsies correlates with the presence of carcinoma in excised cervical epithelium. The objective of this case-control retrospective pilot study was to determine whether or not patterns of IMP3 expression are associated with OED progression to OSCC. Immunohistochemically stained archival tissues (2 groups, age- and site-matched, ≥4 biopsies followed for ≥4 years, transformed [n = 5] and nontransformed [n = 4] to OSCC) were analyzed by light microscopy and with TissueStudio 3.5 image analysis software (Definiens, Munich, Germany). Statistics confirmed comparable initial clinical and histologic features between the transformed and nontransformed groups. Microscopic evaluation revealed greater distribution of moderate to intense IMP3 staining in OED lesions that transformed. Image-analyzed samples revealed that intense IMP3 staining increased over time in those OED lesions that transformed to OSCC (Pearson r; P = .002; all patients combined). In contrast, no such association was noted in nontransformed OED lesions (P = .105). Pearson r values (intense IMP3 expression over time) for each individual patient were: transformed group, 0.82, 0.37, 0.99*, 0.92, and 0.72* (*P = .015); nontransformed group, 0.11, 0.53, −0.70, and 0.57. These data, which show increasing levels of intense IMP3 expression in progressive OED lesions, suggest that high sustained levels of intracellular IMP3 contribute to development of an invasive phenotype." @default.
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- W2057588369 date "2013-12-01" @default.
- W2057588369 modified "2023-09-27" @default.
- W2057588369 title "Sustained Overexpression of Insulin-Like Growth Factor II mRNA–Binding Protein 3 in Oral Epithelial Dysplasia: A Potential Prognostic Biomarker Of Impending Invasion" @default.
- W2057588369 doi "https://doi.org/10.1016/j.oooo.2013.09.051" @default.
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