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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057592439> ?p ?o ?g. }

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• W2057592439 abstract "Astrocytes produce granulocyte/macrophage colony-stimulating factor (GM-CSF) and support the survival and proliferation of microglia. To study the functions of GM-CSF in the central nervous system (CNS), we examined the effects of GM-CSF on cytokine production by glial cells. GM-CSF induced interleukin-6 (IL-6) production by microglia, but not by astrocytes, in a dose-dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. GM-CSF did not induce tumor necrosis factor (TNF)a or IL-1 in microglia and astrocytes, whereas lipopolysaccharide induced all these cytokines. The induction of IL-6 by GM-CSF in microglia was completely inhibited by antibodies to GM-CSF. Neither IL-3 nor macrophage-CSF (M-CSF) induced IL-6 production in microglia. Given that IL-1 and TNFα, monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines." @default.
• W2057592439 created "2016-06-24" @default.
• W2057592439 creator A5070500321 @default.
• W2057592439 creator A5075889151 @default.
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• W2057592439 date "1996-03-01" @default.
• W2057592439 modified "2023-10-18" @default.
• W2057592439 title "Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor" @default.
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• W2057592439 doi "https://doi.org/10.1016/0006-8993(95)01535-3" @default.
• W2057592439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7111018" @default.
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