Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057594097> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2057594097 endingPage "243" @default.
- W2057594097 startingPage "241" @default.
- W2057594097 abstract "A 32 year old patient with refractory complex partial seizures was treated with vigabatrin for 3.5 years. Before starting treatment and at 42 months, lumbar punctures were done and the CSF analyzed for amino acids including GABA. Although the patient experienced a 50% seizure reduction, he underwent a left sided temporal lobectomy, and the tissue sample was also analyzed for amino acid content. It was found that vigabatrin caused a three-fold increase in total and free GABA in both the tissue sample and CSF. There were no other significant changes in the other amino acids analyzed. Seizure reduction seen initially was maintained over the long-term observation period. The finding of a specific increase of GABA in brain tissue and CSF of this patient treated with vigabatrin provides additional support to the concept that the primary effect of vigabatrin is as a selective enzyme activated irreversible inhibitor of GABA transaminase." @default.
- W2057594097 created "2016-06-24" @default.
- W2057594097 creator A5044265198 @default.
- W2057594097 creator A5061862920 @default.
- W2057594097 creator A5072899776 @default.
- W2057594097 date "1993-12-01" @default.
- W2057594097 modified "2023-09-25" @default.
- W2057594097 title "Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system — a case study" @default.
- W2057594097 cites W1981028990 @default.
- W2057594097 cites W1987688314 @default.
- W2057594097 cites W2018393360 @default.
- W2057594097 cites W2035352436 @default.
- W2057594097 cites W2067740407 @default.
- W2057594097 cites W2078196751 @default.
- W2057594097 cites W2106619039 @default.
- W2057594097 cites W2157145551 @default.
- W2057594097 doi "https://doi.org/10.1016/0920-1211(93)90085-l" @default.
- W2057594097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8119275" @default.
- W2057594097 hasPublicationYear "1993" @default.
- W2057594097 type Work @default.
- W2057594097 sameAs 2057594097 @default.
- W2057594097 citedByCount "13" @default.
- W2057594097 crossrefType "journal-article" @default.
- W2057594097 hasAuthorship W2057594097A5044265198 @default.
- W2057594097 hasAuthorship W2057594097A5061862920 @default.
- W2057594097 hasAuthorship W2057594097A5072899776 @default.
- W2057594097 hasConcept C118552586 @default.
- W2057594097 hasConcept C126322002 @default.
- W2057594097 hasConcept C134018914 @default.
- W2057594097 hasConcept C141071460 @default.
- W2057594097 hasConcept C142424586 @default.
- W2057594097 hasConcept C181199279 @default.
- W2057594097 hasConcept C185592680 @default.
- W2057594097 hasConcept C2775858608 @default.
- W2057594097 hasConcept C2777421860 @default.
- W2057594097 hasConcept C2778186239 @default.
- W2057594097 hasConcept C2780837902 @default.
- W2057594097 hasConcept C42219234 @default.
- W2057594097 hasConcept C44575665 @default.
- W2057594097 hasConcept C515207424 @default.
- W2057594097 hasConcept C529278444 @default.
- W2057594097 hasConcept C55493867 @default.
- W2057594097 hasConcept C71924100 @default.
- W2057594097 hasConcept C86803240 @default.
- W2057594097 hasConcept C87355193 @default.
- W2057594097 hasConcept C9497952 @default.
- W2057594097 hasConcept C98274493 @default.
- W2057594097 hasConceptScore W2057594097C118552586 @default.
- W2057594097 hasConceptScore W2057594097C126322002 @default.
- W2057594097 hasConceptScore W2057594097C134018914 @default.
- W2057594097 hasConceptScore W2057594097C141071460 @default.
- W2057594097 hasConceptScore W2057594097C142424586 @default.
- W2057594097 hasConceptScore W2057594097C181199279 @default.
- W2057594097 hasConceptScore W2057594097C185592680 @default.
- W2057594097 hasConceptScore W2057594097C2775858608 @default.
- W2057594097 hasConceptScore W2057594097C2777421860 @default.
- W2057594097 hasConceptScore W2057594097C2778186239 @default.
- W2057594097 hasConceptScore W2057594097C2780837902 @default.
- W2057594097 hasConceptScore W2057594097C42219234 @default.
- W2057594097 hasConceptScore W2057594097C44575665 @default.
- W2057594097 hasConceptScore W2057594097C515207424 @default.
- W2057594097 hasConceptScore W2057594097C529278444 @default.
- W2057594097 hasConceptScore W2057594097C55493867 @default.
- W2057594097 hasConceptScore W2057594097C71924100 @default.
- W2057594097 hasConceptScore W2057594097C86803240 @default.
- W2057594097 hasConceptScore W2057594097C87355193 @default.
- W2057594097 hasConceptScore W2057594097C9497952 @default.
- W2057594097 hasConceptScore W2057594097C98274493 @default.
- W2057594097 hasIssue "3" @default.
- W2057594097 hasLocation W20575940971 @default.
- W2057594097 hasLocation W20575940972 @default.
- W2057594097 hasOpenAccess W2057594097 @default.
- W2057594097 hasPrimaryLocation W20575940971 @default.
- W2057594097 hasRelatedWork W1989002189 @default.
- W2057594097 hasRelatedWork W2014329638 @default.
- W2057594097 hasRelatedWork W2015651815 @default.
- W2057594097 hasRelatedWork W2049806774 @default.
- W2057594097 hasRelatedWork W2063738525 @default.
- W2057594097 hasRelatedWork W2086124772 @default.
- W2057594097 hasRelatedWork W2126115260 @default.
- W2057594097 hasRelatedWork W2748952813 @default.
- W2057594097 hasRelatedWork W3188636519 @default.
- W2057594097 hasRelatedWork W4299845981 @default.
- W2057594097 hasVolume "16" @default.
- W2057594097 isParatext "false" @default.
- W2057594097 isRetracted "false" @default.
- W2057594097 magId "2057594097" @default.
- W2057594097 workType "article" @default.