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• W2057613513 startingPage "e35150" @default.
• W2057613513 abstract "Background Glioblastoma multiforme (GBM) is the most aggressive type of malignant primary brain tumors in adults. Molecular and genetic analysis has advanced our understanding of glioma biology, however mapping the cellular composition of the tumor microenvironment is crucial for understanding the pathology of this dreaded brain cancer. In this study we identified major cell populations attracted by glioma using orthotopic rodent models of human glioma xenografts. Marker-specific, anatomical and morphological analyses revealed a robust influx of host cells into the main tumor bed and tumor satellites. Methodology/Principal Findings Human glioma cell lines and glioma spheroid orthotopic implants were used in rodents. In both models, the xenografts recruited large numbers of host nestin-expressing cells, which formed a ‘network’ with glioma. The host nestin-expressing cells appeared to originate in the subventricular zone ipsilateral to the tumor, and were clearly distinguishable from pericytes that expressed smooth muscle actin. These distinct cell populations established close physical contact in a ‘pair-wise’ manner and migrated together to the deeper layers of tumor satellites and gave rise to tumor vasculature. The GBM biopsy xenografts displayed two different phenotypes: (a) low-generation tumors (first in vivo passage in rats) were highly invasive and non-angiogenic, and host nestin-positive cells that infiltrated into these tumors displayed astrocytic or elongated bipolar morphology; (b) high-generation xenografts (fifth passage) had pronounced cellularity, were angiogenic with ‘glomerulus-like’ microvascular proliferations that contained host nestin-positive cells. Stromal cell-derived factor-1 and its receptor CXCR4 were highly expressed in and around glioma xenografts, suggesting their role in glioma progression and invasion. Conclusions/Significance Our data demonstrate a robust migration of nestin-expressing host cells to glioma, which together with pericytes give rise to tumor vasculature. Mapping the cellular composition of glioma microenvironment and deciphering the complex ‘crosstalk’ between tumor and host may ultimately aid the development of novel anti-glioma therapies." @default.
• W2057613513 created "2016-06-24" @default.
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• W2057613513 date "2012-04-23" @default.
• W2057613513 modified "2023-09-26" @default.
• W2057613513 title "Cellular Host Responses to Gliomas" @default.
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• W2057613513 cites W1570839422 @default.
• W2057613513 cites W1866664159 @default.
• W2057613513 cites W1963765937 @default.
• W2057613513 cites W1970192770 @default.
• W2057613513 cites W1970798179 @default.
• W2057613513 cites W1974791004 @default.
• W2057613513 cites W1975164266 @default.
• W2057613513 cites W1976578289 @default.
• W2057613513 cites W1977934887 @default.
• W2057613513 cites W1979043688 @default.
• W2057613513 cites W1980275866 @default.
• W2057613513 cites W1980441719 @default.
• W2057613513 cites W1980889025 @default.
• W2057613513 cites W1981050269 @default.
• W2057613513 cites W1990785174 @default.
• W2057613513 cites W1993866602 @default.
• W2057613513 cites W1997855586 @default.
• W2057613513 cites W2000929915 @default.
• W2057613513 cites W2001461804 @default.
• W2057613513 cites W2002180033 @default.
• W2057613513 cites W2018093166 @default.
• W2057613513 cites W2018390208 @default.
• W2057613513 cites W2021074358 @default.
• W2057613513 cites W2021442315 @default.
• W2057613513 cites W2023795605 @default.
• W2057613513 cites W2023900974 @default.
• W2057613513 cites W2025370055 @default.
• W2057613513 cites W2029470215 @default.
• W2057613513 cites W2030615367 @default.
• W2057613513 cites W2030701238 @default.
• W2057613513 cites W2035250926 @default.
• W2057613513 cites W2036044314 @default.
• W2057613513 cites W2037827070 @default.
• W2057613513 cites W2040385253 @default.
• W2057613513 cites W2043790651 @default.
• W2057613513 cites W2043834555 @default.
• W2057613513 cites W2046521512 @default.
• W2057613513 cites W2046675963 @default.
• W2057613513 cites W2046716216 @default.
• W2057613513 cites W2047685604 @default.
• W2057613513 cites W2056918364 @default.
• W2057613513 cites W2057608998 @default.
• W2057613513 cites W2058554403 @default.
• W2057613513 cites W2063919202 @default.
• W2057613513 cites W2067613633 @default.
• W2057613513 cites W2074661552 @default.
• W2057613513 cites W2080196370 @default.
• W2057613513 cites W2083628520 @default.
• W2057613513 cites W2092409918 @default.
• W2057613513 cites W2096287682 @default.
• W2057613513 cites W2105156168 @default.
• W2057613513 cites W2105714183 @default.
• W2057613513 cites W2105981681 @default.
• W2057613513 cites W2108688211 @default.
• W2057613513 cites W2112703519 @default.
• W2057613513 cites W2115390024 @default.
• W2057613513 cites W2119242698 @default.
• W2057613513 cites W2127346841 @default.
• W2057613513 cites W2127771136 @default.
• W2057613513 cites W2142792453 @default.
• W2057613513 cites W2148276738 @default.
• W2057613513 cites W2148278891 @default.
• W2057613513 cites W2152474871 @default.
• W2057613513 cites W2156097622 @default.
• W2057613513 cites W2158681922 @default.
• W2057613513 cites W2172266256 @default.
• W2057613513 cites W2803499602 @default.
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• W2057613513 doi "https://doi.org/10.1371/journal.pone.0035150" @default.
• W2057613513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3335155" @default.
• W2057613513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22539956" @default.
• W2057613513 hasPublicationYear "2012" @default.
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