FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057620060> ?p ?o ?g. }

• W2057620060 endingPage "11230" @default.
• W2057620060 startingPage "11220" @default.
• W2057620060 abstract "Synaptic plasticity directs development of the nervous system and is thought to underlie memory storage in adult animals. A great deal of our current understanding of the role of AMPA receptors in synaptic plasticity comes from studies on developing cortex and cell cultures. In the present study, we instead focus on plasticity in mature neurons in the neocortex of adult animals. We find that the glutamate receptor 1 (GluR1) subunit of the AMPA receptor is involved in experience-dependent plasticity in adult cortex in vivo and that it acts in addition to neuronal nitric oxide synthase (αNOS1), an enzyme that produces the rapid synaptic signaling molecule nitric oxide (NO). Potentiation of the spared whisker response, following single whisker experience, is ∼33% less in GluR1-null mutants than in wild types. We found that the remaining plasticity depended on αNOS1. Potentiation was reduced by >42% in the single αNOS1-null mutants and completely abolished in GluR1/αNOS1 double-knock-out mice. However, potentiation in GluR1/NOS3 double knock-outs occurred at similar levels to that seen in GluR1 single knock-outs. Synaptic plasticity in the layer IV to II/III pathway in vitro mirrored the results in vivo, in that LTP was present in GluR1/NOS3 double-knock-out mice but not in the GluR1/αNOS1 animals. While basal levels of NO in cortical slices depended on both αNOS1 and NOS3, NMDA receptor-dependent NO release only depended on αNOS1 and not on NOS3. These findings demonstrate that αNOS1 acts in concert with GluR1 to produce experience-dependent plasticity in the neocortex." @default.
• W2057620060 created "2016-06-24" @default.
• W2057620060 creator A5002087953 @default.
• W2057620060 creator A5005488609 @default.
• W2057620060 creator A5011600124 @default.
• W2057620060 creator A5034560024 @default.
• W2057620060 creator A5052160052 @default.
• W2057620060 creator A5059497313 @default.
• W2057620060 date "2011-08-03" @default.
• W2057620060 modified "2023-09-23" @default.
• W2057620060 title "Experience-Dependent Plasticity Acts via GluR1 and a Novel Neuronal Nitric Oxide Synthase-Dependent Synaptic Mechanism in Adult Cortex" @default.
• W2057620060 cites W1500368251 @default.
• W2057620060 cites W1548401665 @default.
• W2057620060 cites W1587897251 @default.
• W2057620060 cites W1669304660 @default.
• W2057620060 cites W1770152808 @default.
• W2057620060 cites W1832049449 @default.
• W2057620060 cites W1874442292 @default.
• W2057620060 cites W1960607431 @default.
• W2057620060 cites W1964364412 @default.
• W2057620060 cites W1965513983 @default.
• W2057620060 cites W1971095704 @default.
• W2057620060 cites W1979609810 @default.
• W2057620060 cites W1985513367 @default.
• W2057620060 cites W1993135690 @default.
• W2057620060 cites W1993536619 @default.
• W2057620060 cites W1995267843 @default.
• W2057620060 cites W2001097170 @default.
• W2057620060 cites W2005687104 @default.
• W2057620060 cites W2011046807 @default.
• W2057620060 cites W2012678641 @default.
• W2057620060 cites W2013625627 @default.
• W2057620060 cites W2015441228 @default.
• W2057620060 cites W2026161211 @default.
• W2057620060 cites W2029578047 @default.
• W2057620060 cites W2029648956 @default.
• W2057620060 cites W2030609519 @default.
• W2057620060 cites W2033379487 @default.
• W2057620060 cites W2038978204 @default.
• W2057620060 cites W2040470787 @default.
• W2057620060 cites W2040709031 @default.
• W2057620060 cites W2042123292 @default.
• W2057620060 cites W2053926654 @default.
• W2057620060 cites W2054240180 @default.
• W2057620060 cites W2056607792 @default.
• W2057620060 cites W2056830149 @default.
• W2057620060 cites W2065957724 @default.
• W2057620060 cites W2072282121 @default.
• W2057620060 cites W2074953902 @default.
• W2057620060 cites W2080341245 @default.
• W2057620060 cites W2083606437 @default.
• W2057620060 cites W2086175702 @default.
• W2057620060 cites W2097532290 @default.
• W2057620060 cites W2097586258 @default.
• W2057620060 cites W2099936009 @default.
• W2057620060 cites W2100087394 @default.
• W2057620060 cites W2107824553 @default.
• W2057620060 cites W2119268695 @default.
• W2057620060 cites W2124613752 @default.
• W2057620060 cites W2132889095 @default.
• W2057620060 cites W2138747960 @default.
• W2057620060 cites W2145255740 @default.
• W2057620060 cites W2146636442 @default.
• W2057620060 cites W2147166014 @default.
• W2057620060 cites W2151952730 @default.
• W2057620060 cites W2165800227 @default.
• W2057620060 cites W2165940889 @default.
• W2057620060 cites W2170310896 @default.
• W2057620060 doi "https://doi.org/10.1523/jneurosci.1590-11.2011" @default.
• W2057620060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3508401" @default.
• W2057620060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21813683" @default.
• W2057620060 hasPublicationYear "2011" @default.
• W2057620060 type Work @default.
• W2057620060 sameAs 2057620060 @default.
• W2057620060 citedByCount "35" @default.
• W2057620060 countsByYear W20576200602012 @default.
• W2057620060 countsByYear W20576200602013 @default.
• W2057620060 countsByYear W20576200602014 @default.
• W2057620060 countsByYear W20576200602015 @default.
• W2057620060 countsByYear W20576200602016 @default.
• W2057620060 countsByYear W20576200602017 @default.
• W2057620060 countsByYear W20576200602018 @default.
• W2057620060 countsByYear W20576200602019 @default.
• W2057620060 countsByYear W20576200602020 @default.
• W2057620060 countsByYear W20576200602021 @default.
• W2057620060 countsByYear W20576200602022 @default.
• W2057620060 crossrefType "journal-article" @default.
• W2057620060 hasAuthorship W2057620060A5002087953 @default.
• W2057620060 hasAuthorship W2057620060A5005488609 @default.
• W2057620060 hasAuthorship W2057620060A5011600124 @default.
• W2057620060 hasAuthorship W2057620060A5034560024 @default.
• W2057620060 hasAuthorship W2057620060A5052160052 @default.
• W2057620060 hasAuthorship W2057620060A5059497313 @default.
• W2057620060 hasBestOaLocation W20576200601 @default.
• W2057620060 hasConcept C134018914 @default.
• W2057620060 hasConcept C160268369 @default.
• W2057620060 hasConcept C169760540 @default.
• W2057620060 hasConcept C170493617 @default.

• next