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- W2057627587 abstract "Two optically active (100% enantiomeric excess) isomers of ofloxacin [(+/-)-ofloxacin; DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H-pyrido[1,2,3-de] [1,4] benzoxazine-6-carboxylic acid] were prepared by use of their optically resolved synthetic intermediates. One of the isomers, (-)-ofloxacin, was 8 to 128 times more potent in inhibiting the multiplication of gram-positive and gram-negative bacteria than the other, (+)-ofloxacin, and approximately two times more active than the racemate, (+/-)-ofloxacin." @default.
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- W2057627587 date "1986-01-01" @default.
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- W2057627587 title "Synthesis and antibacterial activities of optically active ofloxacin" @default.
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- W2057627587 doi "https://doi.org/10.1128/aac.29.1.163" @default.
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