Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057631439> ?p ?o ?g. }
- W2057631439 endingPage "83" @default.
- W2057631439 startingPage "75" @default.
- W2057631439 abstract "Somatostatin (SRIF) exerts inhibitory effects on virtually all endocrine and exocrine secretions. Five distinct SRIF receptor subtypes (sst 1-5) have been identified. In contrast to the other subtypes, very little is known about specific functions of sst4. We investigated structure and regulation of the human sst4 gene. A genomic clone containing the 5' region of the sst4 gene was isolated. 1.5 kb of the promoter was sequenced and putative transcription factor binding sites were identified. The transcription start site was located 88 nucleotides upstream of the translation start site. A -984 sst4 promoter directed significant levels of luciferase expression in GH4 rat pituitary cells, Skut-1B endometrium cells, and BEAS-2B human bronchial epithelial cells, whereas only low activity was detected in JEG3 chorion carcinoma cells or COS-7 monkey kidney cells. A minimal -209 promoter allowed cell specific expression, its activity in COS-7 cells is not enhanced by co-transfection of the pituitary-specific transcription factor Pit-1. An enhancer element was localized between nt -459 and -984. We did not find any regulation of the sst4 promoter region analyzed by SRIF, forskolin, TPA, IGF-1, EGF, T3, glucocorticoids or 17beta-estradiol. These studies identify the 5' region of the sst4 gene. Furthermore, specific activity of the promoter in various cell lines is demonstrated." @default.
- W2057631439 created "2016-06-24" @default.
- W2057631439 creator A5003639334 @default.
- W2057631439 creator A5032433135 @default.
- W2057631439 creator A5032742966 @default.
- W2057631439 creator A5048396622 @default.
- W2057631439 creator A5067841207 @default.
- W2057631439 date "2002-02-01" @default.
- W2057631439 modified "2023-09-27" @default.
- W2057631439 title "Characterization of the human somatostatin receptor type 4 promoter" @default.
- W2057631439 cites W1970539039 @default.
- W2057631439 cites W1971980406 @default.
- W2057631439 cites W1973110862 @default.
- W2057631439 cites W1985754298 @default.
- W2057631439 cites W1985859969 @default.
- W2057631439 cites W1994794562 @default.
- W2057631439 cites W1995027065 @default.
- W2057631439 cites W1995691719 @default.
- W2057631439 cites W2003164061 @default.
- W2057631439 cites W2006132562 @default.
- W2057631439 cites W2006222114 @default.
- W2057631439 cites W2010934552 @default.
- W2057631439 cites W2020538085 @default.
- W2057631439 cites W2038223982 @default.
- W2057631439 cites W2041804933 @default.
- W2057631439 cites W2049170799 @default.
- W2057631439 cites W2060982850 @default.
- W2057631439 cites W2062551812 @default.
- W2057631439 cites W2066881422 @default.
- W2057631439 cites W2072360771 @default.
- W2057631439 cites W2072999479 @default.
- W2057631439 cites W2073466411 @default.
- W2057631439 cites W2074060609 @default.
- W2057631439 cites W2080232093 @default.
- W2057631439 cites W2083199129 @default.
- W2057631439 cites W2086730856 @default.
- W2057631439 cites W2094843136 @default.
- W2057631439 cites W2118631824 @default.
- W2057631439 cites W2131522538 @default.
- W2057631439 cites W2152185113 @default.
- W2057631439 cites W2221727181 @default.
- W2057631439 cites W2398700478 @default.
- W2057631439 cites W2417772238 @default.
- W2057631439 cites W2475225527 @default.
- W2057631439 cites W178834423 @default.
- W2057631439 doi "https://doi.org/10.1016/s0303-7207(01)00747-x" @default.
- W2057631439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11911948" @default.
- W2057631439 hasPublicationYear "2002" @default.
- W2057631439 type Work @default.
- W2057631439 sameAs 2057631439 @default.
- W2057631439 citedByCount "10" @default.
- W2057631439 countsByYear W20576314392013 @default.
- W2057631439 countsByYear W20576314392018 @default.
- W2057631439 countsByYear W20576314392019 @default.
- W2057631439 crossrefType "journal-article" @default.
- W2057631439 hasAuthorship W2057631439A5003639334 @default.
- W2057631439 hasAuthorship W2057631439A5032433135 @default.
- W2057631439 hasAuthorship W2057631439A5032742966 @default.
- W2057631439 hasAuthorship W2057631439A5048396622 @default.
- W2057631439 hasAuthorship W2057631439A5067841207 @default.
- W2057631439 hasConcept C101762097 @default.
- W2057631439 hasConcept C104317684 @default.
- W2057631439 hasConcept C111936080 @default.
- W2057631439 hasConcept C134018914 @default.
- W2057631439 hasConcept C150008808 @default.
- W2057631439 hasConcept C150194340 @default.
- W2057631439 hasConcept C153911025 @default.
- W2057631439 hasConcept C2776297358 @default.
- W2057631439 hasConcept C54009773 @default.
- W2057631439 hasConcept C55493867 @default.
- W2057631439 hasConcept C80115893 @default.
- W2057631439 hasConcept C86339819 @default.
- W2057631439 hasConcept C86803240 @default.
- W2057631439 hasConceptScore W2057631439C101762097 @default.
- W2057631439 hasConceptScore W2057631439C104317684 @default.
- W2057631439 hasConceptScore W2057631439C111936080 @default.
- W2057631439 hasConceptScore W2057631439C134018914 @default.
- W2057631439 hasConceptScore W2057631439C150008808 @default.
- W2057631439 hasConceptScore W2057631439C150194340 @default.
- W2057631439 hasConceptScore W2057631439C153911025 @default.
- W2057631439 hasConceptScore W2057631439C2776297358 @default.
- W2057631439 hasConceptScore W2057631439C54009773 @default.
- W2057631439 hasConceptScore W2057631439C55493867 @default.
- W2057631439 hasConceptScore W2057631439C80115893 @default.
- W2057631439 hasConceptScore W2057631439C86339819 @default.
- W2057631439 hasConceptScore W2057631439C86803240 @default.
- W2057631439 hasIssue "1-2" @default.
- W2057631439 hasLocation W20576314391 @default.
- W2057631439 hasLocation W20576314392 @default.
- W2057631439 hasOpenAccess W2057631439 @default.
- W2057631439 hasPrimaryLocation W20576314391 @default.
- W2057631439 hasRelatedWork W1993704650 @default.
- W2057631439 hasRelatedWork W2057159931 @default.
- W2057631439 hasRelatedWork W2080216202 @default.
- W2057631439 hasRelatedWork W2104083508 @default.
- W2057631439 hasRelatedWork W2131962335 @default.
- W2057631439 hasRelatedWork W2382036438 @default.
- W2057631439 hasRelatedWork W2416403202 @default.