Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057631978> ?p ?o ?g. }
- W2057631978 endingPage "331" @default.
- W2057631978 startingPage "315" @default.
- W2057631978 abstract "Previous studies suggest baicalein, in addition to its antioxidant effects, protects against hypoxia/reoxygenation injury via its pro-oxidant properties. We hypothesize that a brief period of baicalein treatment prior to ischemia/reperfusion (I/R) may trigger preconditioning protection via a mitochondrial pro-oxidant mechanism. Using an established chick cardiomyocyte model of I/R, cells were preconditioned with baicalein (10 μM) for 10 min followed by 10-min wash prior to I/R. Intracellular oxidants were measured using 2', 7'-dichlorofluorescin diacetate (DCFH/DA). Cell viability was assessed by propidium iodide and apoptosis determined by DNA fragmentation. Baicalein induced a transient but significant increase of DCF fluorescence within the 10-min preconditioning period, and led to significant reduction of cell death (38.9 ± 1.8% vs. 58.7 ± 1.2% in I/R control, n = 6, p < 0.001) and DNA fragmentation after I/R. Cotreatment with N-acetylcysteine (500 μM), mitochondrial complex III electron transport chain inhibitor myxothiazol (1 μM), mitochondrial KATP channel blocker 5-hydroxydecanoate-Na (5-HD, 500 μM) or anion channel inhibitor 4', 4'-diisothiocyanato-stilbene-2, 2'-disulfonic acid (DIDS, 200 μM) resulted in significant abrogation of oxidant increase during induction as well as the protection conferred by baicalein preconditioning. These results suggest that baicalein preconditioning exhibits significant anti-apoptotic protection against cardiomyocyte I/R injury by mitochondrial oxidant signaling, which was in part mediated by mitochondrial KATP channel and anion channel opening." @default.
- W2057631978 created "2016-06-24" @default.
- W2057631978 creator A5003521316 @default.
- W2057631978 creator A5012677271 @default.
- W2057631978 creator A5020836737 @default.
- W2057631978 creator A5042985527 @default.
- W2057631978 creator A5043380401 @default.
- W2057631978 creator A5053307740 @default.
- W2057631978 creator A5055007546 @default.
- W2057631978 creator A5064711465 @default.
- W2057631978 creator A5067060141 @default.
- W2057631978 creator A5077935418 @default.
- W2057631978 creator A5087734698 @default.
- W2057631978 creator A5091642561 @default.
- W2057631978 date "2013-01-01" @default.
- W2057631978 modified "2023-10-12" @default.
- W2057631978 title "Baicalein Preconditioning Protects Cardiomyocytes from Ischemia-Reperfusion Injury via Mitochondrial Oxidant Signaling" @default.
- W2057631978 cites W1560838288 @default.
- W2057631978 cites W1922087192 @default.
- W2057631978 cites W1980364069 @default.
- W2057631978 cites W1981250041 @default.
- W2057631978 cites W1996795211 @default.
- W2057631978 cites W1998950914 @default.
- W2057631978 cites W2002507752 @default.
- W2057631978 cites W2006965409 @default.
- W2057631978 cites W2021850192 @default.
- W2057631978 cites W2022080470 @default.
- W2057631978 cites W2025183582 @default.
- W2057631978 cites W2026690848 @default.
- W2057631978 cites W2030345222 @default.
- W2057631978 cites W2033144455 @default.
- W2057631978 cites W2035060698 @default.
- W2057631978 cites W2037112744 @default.
- W2057631978 cites W2039207179 @default.
- W2057631978 cites W2048547503 @default.
- W2057631978 cites W2049108278 @default.
- W2057631978 cites W2058950044 @default.
- W2057631978 cites W2068616777 @default.
- W2057631978 cites W2070839245 @default.
- W2057631978 cites W2071213207 @default.
- W2057631978 cites W2076904393 @default.
- W2057631978 cites W2082223515 @default.
- W2057631978 cites W2087362900 @default.
- W2057631978 cites W2091471938 @default.
- W2057631978 cites W2092214694 @default.
- W2057631978 cites W2096487007 @default.
- W2057631978 cites W2097029399 @default.
- W2057631978 cites W2100133935 @default.
- W2057631978 cites W2111512232 @default.
- W2057631978 cites W2122501550 @default.
- W2057631978 cites W2124027170 @default.
- W2057631978 cites W2124109702 @default.
- W2057631978 cites W2129978185 @default.
- W2057631978 cites W2130229822 @default.
- W2057631978 cites W2130615448 @default.
- W2057631978 cites W2132697533 @default.
- W2057631978 cites W2136448920 @default.
- W2057631978 cites W2137834530 @default.
- W2057631978 cites W2144640999 @default.
- W2057631978 cites W2145047965 @default.
- W2057631978 cites W2145624529 @default.
- W2057631978 cites W2146217294 @default.
- W2057631978 cites W2151126528 @default.
- W2057631978 cites W2152638788 @default.
- W2057631978 cites W2153190058 @default.
- W2057631978 cites W2199699906 @default.
- W2057631978 cites W2321794803 @default.
- W2057631978 cites W2322029934 @default.
- W2057631978 cites W4242621865 @default.
- W2057631978 cites W4362208330 @default.
- W2057631978 doi "https://doi.org/10.1142/s0192415x13500237" @default.
- W2057631978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23548122" @default.
- W2057631978 hasPublicationYear "2013" @default.
- W2057631978 type Work @default.
- W2057631978 sameAs 2057631978 @default.
- W2057631978 citedByCount "32" @default.
- W2057631978 countsByYear W20576319782013 @default.
- W2057631978 countsByYear W20576319782014 @default.
- W2057631978 countsByYear W20576319782015 @default.
- W2057631978 countsByYear W20576319782016 @default.
- W2057631978 countsByYear W20576319782017 @default.
- W2057631978 countsByYear W20576319782018 @default.
- W2057631978 countsByYear W20576319782020 @default.
- W2057631978 countsByYear W20576319782022 @default.
- W2057631978 countsByYear W20576319782023 @default.
- W2057631978 crossrefType "journal-article" @default.
- W2057631978 hasAuthorship W2057631978A5003521316 @default.
- W2057631978 hasAuthorship W2057631978A5012677271 @default.
- W2057631978 hasAuthorship W2057631978A5020836737 @default.
- W2057631978 hasAuthorship W2057631978A5042985527 @default.
- W2057631978 hasAuthorship W2057631978A5043380401 @default.
- W2057631978 hasAuthorship W2057631978A5053307740 @default.
- W2057631978 hasAuthorship W2057631978A5055007546 @default.
- W2057631978 hasAuthorship W2057631978A5064711465 @default.
- W2057631978 hasAuthorship W2057631978A5067060141 @default.
- W2057631978 hasAuthorship W2057631978A5077935418 @default.
- W2057631978 hasAuthorship W2057631978A5087734698 @default.
- W2057631978 hasAuthorship W2057631978A5091642561 @default.