Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057632421> ?p ?o ?g. }
- W2057632421 endingPage "274" @default.
- W2057632421 startingPage "266" @default.
- W2057632421 abstract "Inhibitors of dipeptidyl peptidase-4 (DPP-4), a key regulator of the actions of incretin hormones, exert antihyperglycemic effects in type 2 diabetic patients. A major unanswered question concerns the potential ability of DPP-4 inhibition to have beneficial disease-modifying effects, specifically to attenuate loss of pancreatic β-cell mass and function due to oxidative stress induced inflammation. Here, we investigated the effects of a potent and selective DPP-4 inhibitor vildagliptin on glycemic control, pancreatic β-cell mass and function, genes and proteins expressions, tumor necrosis factor-alpha, and nitric oxide in an n2-STZ diabetic model of rat with defects in insulin sensitivity and secretion. To induce NIDDM, STZ (sigma chemicals, USA) (90 mg/kg) was administered i.p. to a group of 2 days old pups. Another group of pups received only saline. The pups were weaned for 21 days, and 6 weeks after the injection of STZ, the animals were checked for fasting glucose level (FPG) ≥ 160 mg/dl were considered as diabetic. Significant and dose-dependent correction of postprandial and fasting hyperglycemia was observed in diabetic rats following 8 weeks of chronic therapy. Treatment with vildagliptin showed increase in the number of insulin-positive β-cells in islets and improved the expressions of genes and proteins are responsible for insulin secretions. In addition, treatment of rats with vildagliptin significantly increased insulin content; and decreased the nitric oxide and TNF-alpha concentration. These findings suggest that DPP-4 inhibitors may offer long-lasting efficacy in the treatment of diabetes mellitus by modifying the courses of the disease." @default.
- W2057632421 created "2016-06-24" @default.
- W2057632421 creator A5000780552 @default.
- W2057632421 creator A5001719651 @default.
- W2057632421 creator A5014725093 @default.
- W2057632421 date "2012-07-01" @default.
- W2057632421 modified "2023-09-29" @default.
- W2057632421 title "Vildagliptin selectively ameliorates GLP-1, GLUT4, SREBP-1c mRNA levels and stimulates β-Cell proliferation resulting in improved glucose homeostasis in rats with streptozotocin-induced diabetes" @default.
- W2057632421 cites W1971877745 @default.
- W2057632421 cites W1978297557 @default.
- W2057632421 cites W1997796576 @default.
- W2057632421 cites W2001031720 @default.
- W2057632421 cites W2008948270 @default.
- W2057632421 cites W2010648841 @default.
- W2057632421 cites W2022101780 @default.
- W2057632421 cites W2024409703 @default.
- W2057632421 cites W2030477680 @default.
- W2057632421 cites W2030610610 @default.
- W2057632421 cites W2031055048 @default.
- W2057632421 cites W2032322539 @default.
- W2057632421 cites W2035926403 @default.
- W2057632421 cites W2036678616 @default.
- W2057632421 cites W2039999119 @default.
- W2057632421 cites W2055264960 @default.
- W2057632421 cites W2069030987 @default.
- W2057632421 cites W2075532876 @default.
- W2057632421 cites W2076880341 @default.
- W2057632421 cites W2082604269 @default.
- W2057632421 cites W2096428903 @default.
- W2057632421 cites W2103908751 @default.
- W2057632421 cites W2106036385 @default.
- W2057632421 cites W2109069837 @default.
- W2057632421 cites W2113713934 @default.
- W2057632421 cites W2127409471 @default.
- W2057632421 cites W2127825630 @default.
- W2057632421 cites W2147649093 @default.
- W2057632421 cites W2149341824 @default.
- W2057632421 cites W2156150085 @default.
- W2057632421 cites W2158342810 @default.
- W2057632421 cites W2160234571 @default.
- W2057632421 cites W2171779326 @default.
- W2057632421 cites W2411384485 @default.
- W2057632421 cites W2416208874 @default.
- W2057632421 cites W4231573271 @default.
- W2057632421 cites W4233461383 @default.
- W2057632421 cites W4234825176 @default.
- W2057632421 cites W4235365453 @default.
- W2057632421 cites W4240968870 @default.
- W2057632421 doi "https://doi.org/10.1016/j.jdiacomp.2012.03.013" @default.
- W2057632421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22626875" @default.
- W2057632421 hasPublicationYear "2012" @default.
- W2057632421 type Work @default.
- W2057632421 sameAs 2057632421 @default.
- W2057632421 citedByCount "32" @default.
- W2057632421 countsByYear W20576324212013 @default.
- W2057632421 countsByYear W20576324212015 @default.
- W2057632421 countsByYear W20576324212017 @default.
- W2057632421 countsByYear W20576324212018 @default.
- W2057632421 countsByYear W20576324212019 @default.
- W2057632421 countsByYear W20576324212020 @default.
- W2057632421 countsByYear W20576324212021 @default.
- W2057632421 crossrefType "journal-article" @default.
- W2057632421 hasAuthorship W2057632421A5000780552 @default.
- W2057632421 hasAuthorship W2057632421A5001719651 @default.
- W2057632421 hasAuthorship W2057632421A5014725093 @default.
- W2057632421 hasConcept C126322002 @default.
- W2057632421 hasConcept C134018914 @default.
- W2057632421 hasConcept C156490143 @default.
- W2057632421 hasConcept C2776151105 @default.
- W2057632421 hasConcept C2776188179 @default.
- W2057632421 hasConcept C2776453732 @default.
- W2057632421 hasConcept C2777180221 @default.
- W2057632421 hasConcept C2777391703 @default.
- W2057632421 hasConcept C2778881409 @default.
- W2057632421 hasConcept C2779280383 @default.
- W2057632421 hasConcept C2779306644 @default.
- W2057632421 hasConcept C3018667095 @default.
- W2057632421 hasConcept C519581460 @default.
- W2057632421 hasConcept C555293320 @default.
- W2057632421 hasConcept C71924100 @default.
- W2057632421 hasConceptScore W2057632421C126322002 @default.
- W2057632421 hasConceptScore W2057632421C134018914 @default.
- W2057632421 hasConceptScore W2057632421C156490143 @default.
- W2057632421 hasConceptScore W2057632421C2776151105 @default.
- W2057632421 hasConceptScore W2057632421C2776188179 @default.
- W2057632421 hasConceptScore W2057632421C2776453732 @default.
- W2057632421 hasConceptScore W2057632421C2777180221 @default.
- W2057632421 hasConceptScore W2057632421C2777391703 @default.
- W2057632421 hasConceptScore W2057632421C2778881409 @default.
- W2057632421 hasConceptScore W2057632421C2779280383 @default.
- W2057632421 hasConceptScore W2057632421C2779306644 @default.
- W2057632421 hasConceptScore W2057632421C3018667095 @default.
- W2057632421 hasConceptScore W2057632421C519581460 @default.
- W2057632421 hasConceptScore W2057632421C555293320 @default.
- W2057632421 hasConceptScore W2057632421C71924100 @default.
- W2057632421 hasIssue "4" @default.
- W2057632421 hasLocation W20576324211 @default.
- W2057632421 hasLocation W20576324212 @default.