FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057632732> ?p ?o ?g. }

• W2057632732 endingPage "296" @default.
• W2057632732 startingPage "285" @default.
• W2057632732 abstract "We used synthetic lethal high-throughput screening to interrogate 23,550 compounds for their ability to kill engineered tumorigenic cells but not their isogenic normal cell counterparts. We identified known and novel compounds with genotype-selective activity, including doxorubicin, daunorubicin, mitoxantrone, camptothecin, sangivamycin, echinomycin, bouvardin, NSC146109, and a novel compound that we named erastin. These compounds have increased activity in the presence of hTERT, the SV40 large and small T oncoproteins, the human papillomavirus type 16 (HPV) E6 and E7 oncoproteins, and oncogenic HRAS. We found that overexpressing hTERT and either E7 or LT increased expression of topoisomerase 2alpha and that overexpressing RAS(V12) and ST both increased expression of topoisomerase 1 and sensitized cells to a nonapoptotic cell death process initiated by erastin." @default.
• W2057632732 created "2016-06-24" @default.
• W2057632732 creator A5011008213 @default.
• W2057632732 creator A5030207693 @default.
• W2057632732 creator A5032142783 @default.
• W2057632732 creator A5063875415 @default.
• W2057632732 date "2003-03-01" @default.
• W2057632732 modified "2023-10-06" @default.
• W2057632732 title "Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells" @default.
• W2057632732 cites W1540649941 @default.
• W2057632732 cites W1545398558 @default.
• W2057632732 cites W1620696626 @default.
• W2057632732 cites W1911118961 @default.
• W2057632732 cites W1978932555 @default.
• W2057632732 cites W1982075384 @default.
• W2057632732 cites W1986170848 @default.
• W2057632732 cites W1991443712 @default.
• W2057632732 cites W1993357468 @default.
• W2057632732 cites W1998588464 @default.
• W2057632732 cites W2006704971 @default.
• W2057632732 cites W2007928608 @default.
• W2057632732 cites W2008797552 @default.
• W2057632732 cites W2012804357 @default.
• W2057632732 cites W2016086822 @default.
• W2057632732 cites W2021029116 @default.
• W2057632732 cites W2021983664 @default.
• W2057632732 cites W2022794649 @default.
• W2057632732 cites W2025478017 @default.
• W2057632732 cites W2027345413 @default.
• W2057632732 cites W2033345138 @default.
• W2057632732 cites W2034683861 @default.
• W2057632732 cites W2036495494 @default.
• W2057632732 cites W2038638713 @default.
• W2057632732 cites W2040914101 @default.
• W2057632732 cites W2057106513 @default.
• W2057632732 cites W2057836655 @default.
• W2057632732 cites W2070831760 @default.
• W2057632732 cites W2073051869 @default.
• W2057632732 cites W2074902034 @default.
• W2057632732 cites W2080161935 @default.
• W2057632732 cites W2105006863 @default.
• W2057632732 cites W2114813165 @default.
• W2057632732 cites W2114859236 @default.
• W2057632732 cites W2124477307 @default.
• W2057632732 cites W2129085121 @default.
• W2057632732 cites W2129727010 @default.
• W2057632732 cites W2140857824 @default.
• W2057632732 cites W2151303311 @default.
• W2057632732 cites W2151526351 @default.
• W2057632732 cites W2162525969 @default.
• W2057632732 cites W2328214415 @default.
• W2057632732 cites W4241580271 @default.
• W2057632732 cites W4297069849 @default.
• W2057632732 doi "https://doi.org/10.1016/s1535-6108(03)00050-3" @default.
• W2057632732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12676586" @default.
• W2057632732 hasPublicationYear "2003" @default.
• W2057632732 type Work @default.
• W2057632732 sameAs 2057632732 @default.
• W2057632732 citedByCount "846" @default.
• W2057632732 countsByYear W20576327322012 @default.
• W2057632732 countsByYear W20576327322013 @default.
• W2057632732 countsByYear W20576327322014 @default.
• W2057632732 countsByYear W20576327322015 @default.
• W2057632732 countsByYear W20576327322016 @default.
• W2057632732 countsByYear W20576327322017 @default.
• W2057632732 countsByYear W20576327322018 @default.
• W2057632732 countsByYear W20576327322019 @default.
• W2057632732 countsByYear W20576327322020 @default.
• W2057632732 countsByYear W20576327322021 @default.
• W2057632732 countsByYear W20576327322022 @default.
• W2057632732 countsByYear W20576327322023 @default.
• W2057632732 crossrefType "journal-article" @default.
• W2057632732 hasAuthorship W2057632732A5011008213 @default.
• W2057632732 hasAuthorship W2057632732A5030207693 @default.
• W2057632732 hasAuthorship W2057632732A5032142783 @default.
• W2057632732 hasAuthorship W2057632732A5063875415 @default.
• W2057632732 hasBestOaLocation W20576327321 @default.
• W2057632732 hasConcept C104317684 @default.
• W2057632732 hasConcept C143065580 @default.
• W2057632732 hasConcept C147897179 @default.
• W2057632732 hasConcept C153911025 @default.
• W2057632732 hasConcept C181199279 @default.
• W2057632732 hasConcept C185592680 @default.
• W2057632732 hasConcept C2776694085 @default.
• W2057632732 hasConcept C2778502085 @default.
• W2057632732 hasConcept C2778616834 @default.
• W2057632732 hasConcept C2779682216 @default.
• W2057632732 hasConcept C2780923524 @default.
• W2057632732 hasConcept C2781303535 @default.
• W2057632732 hasConcept C502942594 @default.
• W2057632732 hasConcept C51323132 @default.
• W2057632732 hasConcept C54355233 @default.
• W2057632732 hasConcept C55493867 @default.
• W2057632732 hasConcept C81885089 @default.
• W2057632732 hasConcept C86803240 @default.
• W2057632732 hasConceptScore W2057632732C104317684 @default.
• W2057632732 hasConceptScore W2057632732C143065580 @default.
• W2057632732 hasConceptScore W2057632732C147897179 @default.

• next