Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057632915> ?p ?o ?g. }
- W2057632915 endingPage "275" @default.
- W2057632915 startingPage "251" @default.
- W2057632915 abstract "In the past few years there has been considerable progress in the development of mammalian cell systems for use in genetic toxicology by the stable transfer of genes/cDNAs coding for drug metabolizing enzymes directly into the target cell. Alternative approaches have also been developed in which mammalian cells are transiently transfected with cDNAs coding for drug-metabolizing enzymes and S9 preparations expressing a single metabolizing enzyme isolated and used for metabolic activation. Progress in these areas is reviewed here and the relative merits of the different approaches are discussed. Work to date has focused primarily on the cytochrome P450 family of enzymes, although other enzyme systems involved in xenobiotic metabolism have been used. The central theme of this review is the transfer of genetic information to improve the metabolic capability of cell systems used in genetic toxicology. However, a basic philosophy of the review is that genetic manipulation of cultured mammalian cells has the potential for developing systems to be used to better understand chemically induced toxicological effects." @default.
- W2057632915 created "2016-06-24" @default.
- W2057632915 creator A5030016727 @default.
- W2057632915 creator A5069368372 @default.
- W2057632915 creator A5088332392 @default.
- W2057632915 date "1992-09-01" @default.
- W2057632915 modified "2023-09-27" @default.
- W2057632915 title "Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology" @default.
- W2057632915 cites W1483226399 @default.
- W2057632915 cites W1522002051 @default.
- W2057632915 cites W1522143119 @default.
- W2057632915 cites W1526269646 @default.
- W2057632915 cites W1557658741 @default.
- W2057632915 cites W1579052358 @default.
- W2057632915 cites W1584084472 @default.
- W2057632915 cites W1602419259 @default.
- W2057632915 cites W1706025319 @default.
- W2057632915 cites W1722287580 @default.
- W2057632915 cites W1725864523 @default.
- W2057632915 cites W1771489119 @default.
- W2057632915 cites W1946287511 @default.
- W2057632915 cites W1968820402 @default.
- W2057632915 cites W1971539282 @default.
- W2057632915 cites W1971580907 @default.
- W2057632915 cites W1975091639 @default.
- W2057632915 cites W1976756683 @default.
- W2057632915 cites W1978372645 @default.
- W2057632915 cites W1980571658 @default.
- W2057632915 cites W1980651107 @default.
- W2057632915 cites W1980829113 @default.
- W2057632915 cites W1982993731 @default.
- W2057632915 cites W1987081651 @default.
- W2057632915 cites W1987923762 @default.
- W2057632915 cites W1988000583 @default.
- W2057632915 cites W1990541549 @default.
- W2057632915 cites W1991404763 @default.
- W2057632915 cites W1994752387 @default.
- W2057632915 cites W1995421298 @default.
- W2057632915 cites W1996124369 @default.
- W2057632915 cites W2004817437 @default.
- W2057632915 cites W2006876500 @default.
- W2057632915 cites W2007972960 @default.
- W2057632915 cites W2008774977 @default.
- W2057632915 cites W2009421890 @default.
- W2057632915 cites W2011267529 @default.
- W2057632915 cites W2013873570 @default.
- W2057632915 cites W2016556820 @default.
- W2057632915 cites W2023871900 @default.
- W2057632915 cites W2024583045 @default.
- W2057632915 cites W2036895138 @default.
- W2057632915 cites W2038556205 @default.
- W2057632915 cites W2038657917 @default.
- W2057632915 cites W2040057136 @default.
- W2057632915 cites W2043263657 @default.
- W2057632915 cites W2045172647 @default.
- W2057632915 cites W2048894559 @default.
- W2057632915 cites W2050051406 @default.
- W2057632915 cites W2051649196 @default.
- W2057632915 cites W2052428509 @default.
- W2057632915 cites W2065340102 @default.
- W2057632915 cites W2071332031 @default.
- W2057632915 cites W2076663750 @default.
- W2057632915 cites W2076913410 @default.
- W2057632915 cites W2077483112 @default.
- W2057632915 cites W2080076317 @default.
- W2057632915 cites W2080216765 @default.
- W2057632915 cites W2081952647 @default.
- W2057632915 cites W2082119404 @default.
- W2057632915 cites W2082356664 @default.
- W2057632915 cites W2082438222 @default.
- W2057632915 cites W2083656724 @default.
- W2057632915 cites W2084686194 @default.
- W2057632915 cites W2087018701 @default.
- W2057632915 cites W2089160912 @default.
- W2057632915 cites W2089185855 @default.
- W2057632915 cites W2092191147 @default.
- W2057632915 cites W2092806325 @default.
- W2057632915 cites W2093152212 @default.
- W2057632915 cites W2094657382 @default.
- W2057632915 cites W2098008357 @default.
- W2057632915 cites W2118386638 @default.
- W2057632915 cites W2124251966 @default.
- W2057632915 cites W2131504112 @default.
- W2057632915 cites W2132927623 @default.
- W2057632915 cites W2139234269 @default.
- W2057632915 cites W2143481327 @default.
- W2057632915 cites W2161933510 @default.
- W2057632915 cites W2166260496 @default.
- W2057632915 cites W2167593137 @default.
- W2057632915 cites W2288247494 @default.
- W2057632915 cites W2315881010 @default.
- W2057632915 cites W4239785112 @default.
- W2057632915 cites W4253511719 @default.
- W2057632915 cites W54050501 @default.
- W2057632915 doi "https://doi.org/10.1016/0165-1110(92)90047-d" @default.
- W2057632915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1381053" @default.
- W2057632915 hasPublicationYear "1992" @default.
- W2057632915 type Work @default.