Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057633398> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2057633398 endingPage "244" @default.
- W2057633398 startingPage "241" @default.
- W2057633398 abstract "The effects of selective A1 and A2A adenosine receptor compounds in two mouse models of acute nociception were studied: acetic acid-induced writhing and the hot plate assays. Stimulation of A1 receptors by 2-chloro-N6-cyclopentyl-adenosine (CCPA, 0.01–0.1 mg/kg, i.p.; A1Ki=6 nM) or blockade of A2A receptors by 5-amino-7-(β-phenylethyl)-2-(8-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine (SCH58261, 1–10 mg/kg, i.p.; A2AKi=1.3 nM) produced anti-nociceptive effects. At the highest dose tested, CCPA and SCH58261 reduced the number of writhings by 79 and 99%, respectively. On the contrary, the A1 antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (A1Ki=2.8 nM) and the A2A agonist 2-(4-[2-carboxyethyl])phenethylamino-5′-N-ethylcarboxamido-adenosine-hydrochloride (GGS21680) produced pro-nociceptive effects in both tests. These findings suggest for the first time that blockade of A2A adenosine receptors produces anti-nociceptive effects." @default.
- W2057633398 created "2016-06-24" @default.
- W2057633398 creator A5018360276 @default.
- W2057633398 creator A5037632094 @default.
- W2057633398 creator A5042140947 @default.
- W2057633398 creator A5046610533 @default.
- W2057633398 date "2002-08-01" @default.
- W2057633398 modified "2023-09-23" @default.
- W2057633398 title "Effects of A1 and A2A adenosine receptor ligands in mouse acute models of pain" @default.
- W2057633398 cites W1521659744 @default.
- W2057633398 cites W1849463791 @default.
- W2057633398 cites W1968599797 @default.
- W2057633398 cites W1983467328 @default.
- W2057633398 cites W1995941325 @default.
- W2057633398 cites W2028858857 @default.
- W2057633398 cites W2034102455 @default.
- W2057633398 cites W2045001050 @default.
- W2057633398 cites W2050338155 @default.
- W2057633398 cites W2069775060 @default.
- W2057633398 cites W2178156827 @default.
- W2057633398 doi "https://doi.org/10.1016/s0304-3940(02)00524-4" @default.
- W2057633398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12147316" @default.
- W2057633398 hasPublicationYear "2002" @default.
- W2057633398 type Work @default.
- W2057633398 sameAs 2057633398 @default.
- W2057633398 citedByCount "48" @default.
- W2057633398 countsByYear W20576333982012 @default.
- W2057633398 countsByYear W20576333982013 @default.
- W2057633398 countsByYear W20576333982015 @default.
- W2057633398 countsByYear W20576333982016 @default.
- W2057633398 countsByYear W20576333982019 @default.
- W2057633398 countsByYear W20576333982020 @default.
- W2057633398 countsByYear W20576333982022 @default.
- W2057633398 countsByYear W20576333982023 @default.
- W2057633398 crossrefType "journal-article" @default.
- W2057633398 hasAuthorship W2057633398A5018360276 @default.
- W2057633398 hasAuthorship W2057633398A5037632094 @default.
- W2057633398 hasAuthorship W2057633398A5042140947 @default.
- W2057633398 hasAuthorship W2057633398A5046610533 @default.
- W2057633398 hasConcept C126322002 @default.
- W2057633398 hasConcept C134018914 @default.
- W2057633398 hasConcept C15490471 @default.
- W2057633398 hasConcept C170493617 @default.
- W2057633398 hasConcept C182683403 @default.
- W2057633398 hasConcept C185592680 @default.
- W2057633398 hasConcept C24998067 @default.
- W2057633398 hasConcept C2776991684 @default.
- W2057633398 hasConcept C2778491162 @default.
- W2057633398 hasConcept C2778938600 @default.
- W2057633398 hasConcept C2781225136 @default.
- W2057633398 hasConcept C55493867 @default.
- W2057633398 hasConcept C67907053 @default.
- W2057633398 hasConcept C71924100 @default.
- W2057633398 hasConcept C98274493 @default.
- W2057633398 hasConceptScore W2057633398C126322002 @default.
- W2057633398 hasConceptScore W2057633398C134018914 @default.
- W2057633398 hasConceptScore W2057633398C15490471 @default.
- W2057633398 hasConceptScore W2057633398C170493617 @default.
- W2057633398 hasConceptScore W2057633398C182683403 @default.
- W2057633398 hasConceptScore W2057633398C185592680 @default.
- W2057633398 hasConceptScore W2057633398C24998067 @default.
- W2057633398 hasConceptScore W2057633398C2776991684 @default.
- W2057633398 hasConceptScore W2057633398C2778491162 @default.
- W2057633398 hasConceptScore W2057633398C2778938600 @default.
- W2057633398 hasConceptScore W2057633398C2781225136 @default.
- W2057633398 hasConceptScore W2057633398C55493867 @default.
- W2057633398 hasConceptScore W2057633398C67907053 @default.
- W2057633398 hasConceptScore W2057633398C71924100 @default.
- W2057633398 hasConceptScore W2057633398C98274493 @default.
- W2057633398 hasIssue "3" @default.
- W2057633398 hasLocation W20576333981 @default.
- W2057633398 hasLocation W20576333982 @default.
- W2057633398 hasOpenAccess W2057633398 @default.
- W2057633398 hasPrimaryLocation W20576333981 @default.
- W2057633398 hasRelatedWork W1914750790 @default.
- W2057633398 hasRelatedWork W1970002446 @default.
- W2057633398 hasRelatedWork W1994645281 @default.
- W2057633398 hasRelatedWork W2047370387 @default.
- W2057633398 hasRelatedWork W2057018428 @default.
- W2057633398 hasRelatedWork W2059770466 @default.
- W2057633398 hasRelatedWork W2155420070 @default.
- W2057633398 hasRelatedWork W2925336126 @default.
- W2057633398 hasRelatedWork W3087885511 @default.
- W2057633398 hasRelatedWork W81717109 @default.
- W2057633398 hasVolume "328" @default.
- W2057633398 isParatext "false" @default.
- W2057633398 isRetracted "false" @default.
- W2057633398 magId "2057633398" @default.
- W2057633398 workType "article" @default.