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- W2057634037 abstract "In Drosophila, gustatory receptor neurons (GRNs) occur within hair-like structures called sensilla. Most taste sensilla house four GRNs, which have been named according to their preferred sensitivity to basic stimuli: water (W cell), sugars (S cell), salt at low concentration (L1 cell), and salt at high concentration (L2 cell). Labellar taste sensilla are classified into three types, l-, s-, and i-type, according to their length and location. Of these, l- and s-type labellar sensilla possess these four cells, but most i-type sensilla house only two GRNs. In i-type sensilla, we demonstrate here that the first GRN responds to sugar and to low concentrations of salt (10–50 mM NaCl). The second GRN detects a range of bitter compounds, among which strychnine is the most potent; and also to salt at high concentrations (over 400 mM NaCl). Neither type of GRN responds to water. The detection of feeding stimulants in i-type sensilla appears to be performed by one GRN with the combined properties of S + L1 cells, while the other GRN detects feeding inhibitors in a similar manner to bitter-sensitive L2 cells on the legs. These sensilla thus house two GRNs having an antagonistic effect on behavior, suggesting that the expression of taste receptors is segregated across them accordingly. © 2004 Wiley Periodicals, Inc. J Neurobiol, 2004" @default.
- W2057634037 created "2016-06-24" @default.
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- W2057634037 date "2004-01-01" @default.
- W2057634037 modified "2023-10-11" @default.
- W2057634037 title "Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste inDrosophila" @default.
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- W2057634037 doi "https://doi.org/10.1002/neu.20063" @default.
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