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- W2057637112 abstract "Infection in vitro of differentiating chick embryo neuroretinal cells with avian sarcoma viruses UR1 and UR2 results in mitogenic stimulation and morphologic conversion of both support neuronal cells. This was shown by the continuous propagation of transformed cells for over 4 months and growth of reaggregated colonies in liquid medium as well as in soft agar. Production of the transforming proteins p 150 gag-fps and p68 gag-ros of UR1 and UR2, respectively, was similar to that of transformed chick embryo fibroblasts, as judged from in vitro kinase activity assays. The two protein subunits, T beta and T gamma, but not T alpha of the GTP binding protein transducin, found in the retina of many animal species, were present in control neuroretinal cells. Infection with Rous sarcoma virus or UR2 resulted in an inhibition of T gamma synthesis and enhancement of T beta-like protein production." @default.
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- W2057637112 date "1987-10-01" @default.
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- W2057637112 title "Infection of neuroretinal cells in vitro by avian sarcoma viruses UR1 and UR2: Transformation, cell growth stimulation, and changes in transducin levels" @default.
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- W2057637112 doi "https://doi.org/10.1016/0042-6822(87)90023-7" @default.
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