Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057642902> ?p ?o ?g. }
- W2057642902 endingPage "132" @default.
- W2057642902 startingPage "109" @default.
- W2057642902 abstract "When nigro-striatal and meso-cortical neurons degenerate there is a loss of dopamine in the terminal fields and an accumulation of amines in the axons of these systems as they traverse the hypothalamus through the medial forebrain bundle. Traditional lines of thought have attributed the occurrence of motor and consummatory deficits which occur after dopamine neuron degeneration to the loss of functional dopamine neurotransmitter in the terminal fields. However we have hypothesized that hypothalamic amine accumulation represents an area of brain tissue where processes such as neurotransmitter release ephaptic transmission or local axon swelling may be affecting adjacent neurons and may thereby participate in the production of behavioural deficits. There is a considerable amount of evidence from studies on both peripheral and central catecholamine-containing neurons indicating that when their axons degenerate a release of functional neurotransmitter can occur. Information from neuropharmacological studies indicates that several drugs which facilitate behavioural recovery from dopamine-depleting lesions may do so by affecting amine release or receptor sensitivity near areas of accumulation rather than depleted terminal fields. We conclude that amine accumulation is a component of dopamine neuron degeneration which should be considered when assessing the role of the central catecholamine systems in the control of various behavioural and physiological processes." @default.
- W2057642902 created "2016-06-24" @default.
- W2057642902 creator A5055259070 @default.
- W2057642902 creator A5088770561 @default.
- W2057642902 date "1985-06-01" @default.
- W2057642902 modified "2023-10-14" @default.
- W2057642902 title "Amine accumulation in behavioural pathology" @default.
- W2057642902 cites W1182815467 @default.
- W2057642902 cites W1238819995 @default.
- W2057642902 cites W135505035 @default.
- W2057642902 cites W137016290 @default.
- W2057642902 cites W1639605928 @default.
- W2057642902 cites W1703545573 @default.
- W2057642902 cites W1896642802 @default.
- W2057642902 cites W1917267019 @default.
- W2057642902 cites W1964648038 @default.
- W2057642902 cites W1964891285 @default.
- W2057642902 cites W1964919650 @default.
- W2057642902 cites W1965438700 @default.
- W2057642902 cites W1965473644 @default.
- W2057642902 cites W1965739418 @default.
- W2057642902 cites W1965761402 @default.
- W2057642902 cites W1966460171 @default.
- W2057642902 cites W1966544805 @default.
- W2057642902 cites W1966990176 @default.
- W2057642902 cites W1967722117 @default.
- W2057642902 cites W1970701381 @default.
- W2057642902 cites W1972917179 @default.
- W2057642902 cites W1974617384 @default.
- W2057642902 cites W1974723369 @default.
- W2057642902 cites W1974899503 @default.
- W2057642902 cites W1974912088 @default.
- W2057642902 cites W1975133575 @default.
- W2057642902 cites W1977246983 @default.
- W2057642902 cites W1978581566 @default.
- W2057642902 cites W1978830620 @default.
- W2057642902 cites W1979343721 @default.
- W2057642902 cites W1979779106 @default.
- W2057642902 cites W1980155039 @default.
- W2057642902 cites W1981557457 @default.
- W2057642902 cites W1981823905 @default.
- W2057642902 cites W1982142817 @default.
- W2057642902 cites W1982350946 @default.
- W2057642902 cites W1982511121 @default.
- W2057642902 cites W1983925299 @default.
- W2057642902 cites W1983962616 @default.
- W2057642902 cites W1984646993 @default.
- W2057642902 cites W1984767115 @default.
- W2057642902 cites W1984817578 @default.
- W2057642902 cites W1985218351 @default.
- W2057642902 cites W1985561353 @default.
- W2057642902 cites W1985877156 @default.
- W2057642902 cites W1986012426 @default.
- W2057642902 cites W1986592378 @default.
- W2057642902 cites W1986738434 @default.
- W2057642902 cites W1986754603 @default.
- W2057642902 cites W1988273890 @default.
- W2057642902 cites W1988577667 @default.
- W2057642902 cites W1988792695 @default.
- W2057642902 cites W1989502575 @default.
- W2057642902 cites W1989810887 @default.
- W2057642902 cites W1989851808 @default.
- W2057642902 cites W1989930625 @default.
- W2057642902 cites W1990527736 @default.
- W2057642902 cites W1991831598 @default.
- W2057642902 cites W1994395762 @default.
- W2057642902 cites W1994429247 @default.
- W2057642902 cites W1994531283 @default.
- W2057642902 cites W1995332170 @default.
- W2057642902 cites W1995543291 @default.
- W2057642902 cites W1998760932 @default.
- W2057642902 cites W1999421258 @default.
- W2057642902 cites W2000269824 @default.
- W2057642902 cites W2000459510 @default.
- W2057642902 cites W2000533395 @default.
- W2057642902 cites W2000794838 @default.
- W2057642902 cites W2001405581 @default.
- W2057642902 cites W2001517653 @default.
- W2057642902 cites W2003573538 @default.
- W2057642902 cites W2003986105 @default.
- W2057642902 cites W2004018560 @default.
- W2057642902 cites W2004551711 @default.
- W2057642902 cites W2004615355 @default.
- W2057642902 cites W2005026898 @default.
- W2057642902 cites W2005673668 @default.
- W2057642902 cites W2006356056 @default.
- W2057642902 cites W2006497440 @default.
- W2057642902 cites W2007586845 @default.
- W2057642902 cites W2007661112 @default.
- W2057642902 cites W2007912397 @default.
- W2057642902 cites W2008261586 @default.
- W2057642902 cites W2008930316 @default.
- W2057642902 cites W2009748494 @default.
- W2057642902 cites W2009874687 @default.
- W2057642902 cites W2011307778 @default.
- W2057642902 cites W2011342898 @default.
- W2057642902 cites W2011413942 @default.
- W2057642902 cites W2011815576 @default.