FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057643141> ?p ?o ?g. }

• W2057643141 endingPage "888" @default.
• W2057643141 startingPage "880" @default.
• W2057643141 abstract "The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia. The major effect of adenosine is to suppress network activity via the activation of A1 receptors. Here we report that in immature cerebellar slices, the activation of A1 receptors has variable effects on parallel fibre synaptic transmission, ranging from zero depression to an almost complete abolition of transmission. Concentration–response curves suggest that the heterogeneity of inhibition stems from differences in A1 receptor properties which could include coupling to downstream effectors. There is less variation in the effects of adenosine at parallel fibre synapses in slices from older rats and thus adenosine signalling appears developmentally regulated. In the cerebellum, hypoxia increases the concentration of extracellular adenosine leading to the activation of A1 receptors (at adenosine-sensitive parallel fibre synapses) and the suppression of glutamate release. It would be predicted that the synapses that were insensitive to adenosine would be less depressed by hypoxia and thus maintain function during metabolic stress. However those synapses which were insensitive to adenosine were rapidly inhibited by hypoxia via a mechanism which was not reversed by blocking A1 receptors. Thus another mechanism must be responsible for the hypoxia-mediated depression at these synapses. These different mechanisms of depression may be important for cell survival and for maintenance of cerebellar function following oxygen starvation." @default.
• W2057643141 created "2016-06-24" @default.
• W2057643141 creator A5011526893 @default.
• W2057643141 creator A5032520482 @default.
• W2057643141 date "2011-09-01" @default.
• W2057643141 modified "2023-10-04" @default.
• W2057643141 title "A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia" @default.
• W2057643141 cites W1488197968 @default.
• W2057643141 cites W1533812565 @default.
• W2057643141 cites W1571745125 @default.
• W2057643141 cites W1582406974 @default.
• W2057643141 cites W1658796519 @default.
• W2057643141 cites W1966635399 @default.
• W2057643141 cites W1989512553 @default.
• W2057643141 cites W1995378755 @default.
• W2057643141 cites W1996748355 @default.
• W2057643141 cites W2001004870 @default.
• W2057643141 cites W2003817740 @default.
• W2057643141 cites W2013845069 @default.
• W2057643141 cites W2016036161 @default.
• W2057643141 cites W2022320148 @default.
• W2057643141 cites W2024207498 @default.
• W2057643141 cites W2037429535 @default.
• W2057643141 cites W2048461186 @default.
• W2057643141 cites W2053642263 @default.
• W2057643141 cites W2054522785 @default.
• W2057643141 cites W2057283048 @default.
• W2057643141 cites W2057693726 @default.
• W2057643141 cites W2061388579 @default.
• W2057643141 cites W2066015662 @default.
• W2057643141 cites W2074632818 @default.
• W2057643141 cites W2077001917 @default.
• W2057643141 cites W2080396236 @default.
• W2057643141 cites W2090911265 @default.
• W2057643141 cites W2092544119 @default.
• W2057643141 cites W2093452723 @default.
• W2057643141 cites W2101196555 @default.
• W2057643141 cites W2110742628 @default.
• W2057643141 cites W2145758516 @default.
• W2057643141 cites W2146726943 @default.
• W2057643141 cites W2157990225 @default.
• W2057643141 cites W2158586551 @default.
• W2057643141 cites W2163794421 @default.
• W2057643141 doi "https://doi.org/10.1016/j.neuropharm.2011.06.006" @default.
• W2057643141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21693125" @default.
• W2057643141 hasPublicationYear "2011" @default.
• W2057643141 type Work @default.
• W2057643141 sameAs 2057643141 @default.
• W2057643141 citedByCount "3" @default.
• W2057643141 countsByYear W20576431412014 @default.
• W2057643141 countsByYear W20576431412019 @default.
• W2057643141 countsByYear W20576431412021 @default.
• W2057643141 crossrefType "journal-article" @default.
• W2057643141 hasAuthorship W2057643141A5011526893 @default.
• W2057643141 hasAuthorship W2057643141A5032520482 @default.
• W2057643141 hasBestOaLocation W20576431412 @default.
• W2057643141 hasConcept C12554922 @default.
• W2057643141 hasConcept C126322002 @default.
• W2057643141 hasConcept C134018914 @default.
• W2057643141 hasConcept C169760540 @default.
• W2057643141 hasConcept C170493617 @default.
• W2057643141 hasConcept C172590197 @default.
• W2057643141 hasConcept C178790620 @default.
• W2057643141 hasConcept C182683403 @default.
• W2057643141 hasConcept C185592680 @default.
• W2057643141 hasConcept C200170125 @default.
• W2057643141 hasConcept C25498285 @default.
• W2057643141 hasConcept C2776991684 @default.
• W2057643141 hasConcept C2776992512 @default.
• W2057643141 hasConcept C2778938600 @default.
• W2057643141 hasConcept C2779652256 @default.
• W2057643141 hasConcept C540031477 @default.
• W2057643141 hasConcept C55493867 @default.
• W2057643141 hasConcept C61174792 @default.
• W2057643141 hasConcept C67907053 @default.
• W2057643141 hasConcept C71924100 @default.
• W2057643141 hasConcept C7836513 @default.
• W2057643141 hasConcept C86803240 @default.
• W2057643141 hasConcept C95444343 @default.
• W2057643141 hasConceptScore W2057643141C12554922 @default.
• W2057643141 hasConceptScore W2057643141C126322002 @default.
• W2057643141 hasConceptScore W2057643141C134018914 @default.
• W2057643141 hasConceptScore W2057643141C169760540 @default.
• W2057643141 hasConceptScore W2057643141C170493617 @default.
• W2057643141 hasConceptScore W2057643141C172590197 @default.
• W2057643141 hasConceptScore W2057643141C178790620 @default.
• W2057643141 hasConceptScore W2057643141C182683403 @default.
• W2057643141 hasConceptScore W2057643141C185592680 @default.
• W2057643141 hasConceptScore W2057643141C200170125 @default.
• W2057643141 hasConceptScore W2057643141C25498285 @default.
• W2057643141 hasConceptScore W2057643141C2776991684 @default.
• W2057643141 hasConceptScore W2057643141C2776992512 @default.
• W2057643141 hasConceptScore W2057643141C2778938600 @default.
• W2057643141 hasConceptScore W2057643141C2779652256 @default.
• W2057643141 hasConceptScore W2057643141C540031477 @default.
• W2057643141 hasConceptScore W2057643141C55493867 @default.
• W2057643141 hasConceptScore W2057643141C61174792 @default.
• W2057643141 hasConceptScore W2057643141C67907053 @default.

• next