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• W2057643830 startingPage "52" @default.
• W2057643830 abstract "Here, we report the development of a peptide−nucleic acid (PNA)-modified ion-sensitive field-effect transistor (IS-FET)-based biosensor that takes advantage of the change in the surface potential upon hybridization of a negatively charged DNA. PNA was immobilized on a silicon nitride gate insulator by an addition reaction between a maleimide group introduced on the gate surface, the succinimide group of N-(6-maleimidocaproyloxy) succinimide, and the thiol group of the terminal cysteine in PNA. The surface was characterized after each step of the reaction by X-ray photoelectron spectroscopy analysis, and the kinetic analysis of the hybridization events was assessed by surface plasmon resonance. In addition, we measured the ζ-potential before and after PNA−DNA hybridization in the presence of counterions to investigate the change in surface charge density at the surface−solution interface within the order of the Debye length. On the basis of the ζ-potential, the surface charge density, ΔQ, calculated using the Grahame equation was approximately 4.0 × 10-3 C/m2 and the estimated number of hybridized molecules was at least 1.7 × 1011/cm2. The I−V characteristics revealed that the PNA−DNA duplexes induce a positive shift in the threshold voltage, VT, and a decrease in the saturated drain current, ID. These results demonstrate that direct detection of DNA hybridization should be possible using a PNA-modified IS-FET-based biosensor. PNA is particularly advantageous for this system because it enables highly specific and selective binding at low ionic strength." @default.
• W2057643830 created "2016-06-24" @default.
• W2057643830 creator A5019503262 @default.
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• W2057643830 date "2006-11-17" @default.
• W2057643830 modified "2023-10-17" @default.
• W2057643830 title "Peptide−Nucleic Acid-Modified Ion-Sensitive Field-Effect Transistor-Based Biosensor for Direct Detection of DNA Hybridization" @default.
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• W2057643830 doi "https://doi.org/10.1021/ac060273y" @default.
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