FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057645411> ?p ?o ?g. }

• W2057645411 endingPage "4508" @default.
• W2057645411 startingPage "4502" @default.
• W2057645411 abstract "Laser-capture microdissection was coupled with PCR to define the mitochondrial genotype of aged muscle fibers exhibiting mitochondrial enzymatic abnormalities. These electron transport system (ETS) abnormalities accumulate with age, are localized segmentally along muscle fibers, are associated with fiber atrophy and may contribute to age-related fiber loss. DNA extracted from single, 10 µm thick, ETS abnormal muscle fibers, as well as sections from normal fibers, served as templates for PCR-based deletion analysis. Large mitochondrial (mt) DNA deletion mutations (4.4–9.7 kb) were detected in all 29 ETS abnormal fibers analyzed. Deleted mtDNA genomes were detected only in the regions of the fibers with ETS abnormalities; adjacent phenotypically normal portions of the same fiber contained wild-type mtDNA. In addition, identical mtDNA deletion mutations were found within different sections of the same abnormal region. These findings demonstrate that large deletion mutations are associated with ETS abnormalities in aged rat muscle and that, within a fiber, deletion mutations are clonal. The displacement of wild-type mtDNAs with mutant mtDNAs results in concomitant mitochondrial enzymatic abnormalities, fiber atrophy and fiber breakage." @default.
• W2057645411 created "2016-06-24" @default.
• W2057645411 creator A5024014571 @default.
• W2057645411 creator A5027323609 @default.
• W2057645411 creator A5028985183 @default.
• W2057645411 creator A5066563633 @default.
• W2057645411 date "2001-11-01" @default.
• W2057645411 modified "2023-09-25" @default.
• W2057645411 title "Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection" @default.
• W2057645411 cites W1619890556 @default.
• W2057645411 cites W1887455807 @default.
• W2057645411 cites W1964114495 @default.
• W2057645411 cites W1970268474 @default.
• W2057645411 cites W1971104692 @default.
• W2057645411 cites W1974396693 @default.
• W2057645411 cites W1983422827 @default.
• W2057645411 cites W1984630129 @default.
• W2057645411 cites W1988269137 @default.
• W2057645411 cites W1994496497 @default.
• W2057645411 cites W1994720165 @default.
• W2057645411 cites W1996052541 @default.
• W2057645411 cites W1999069234 @default.
• W2057645411 cites W2002736146 @default.
• W2057645411 cites W2005261119 @default.
• W2057645411 cites W2011771712 @default.
• W2057645411 cites W2028483364 @default.
• W2057645411 cites W2031619656 @default.
• W2057645411 cites W2031654071 @default.
• W2057645411 cites W2037717843 @default.
• W2057645411 cites W2040889343 @default.
• W2057645411 cites W2044494908 @default.
• W2057645411 cites W2050303681 @default.
• W2057645411 cites W2050821204 @default.
• W2057645411 cites W2053141759 @default.
• W2057645411 cites W2063301281 @default.
• W2057645411 cites W2064502414 @default.
• W2057645411 cites W2066250257 @default.
• W2057645411 cites W2068663070 @default.
• W2057645411 cites W2072627973 @default.
• W2057645411 cites W2086896876 @default.
• W2057645411 cites W2090369699 @default.
• W2057645411 cites W2091199047 @default.
• W2057645411 cites W2094354899 @default.
• W2057645411 cites W2094414605 @default.
• W2057645411 cites W2109876580 @default.
• W2057645411 cites W2130344015 @default.
• W2057645411 cites W2141586642 @default.
• W2057645411 cites W2154812708 @default.
• W2057645411 doi "https://doi.org/10.1093/nar/29.21.4502" @default.
• W2057645411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/60181" @default.
• W2057645411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11691938" @default.
• W2057645411 hasPublicationYear "2001" @default.
• W2057645411 type Work @default.
• W2057645411 sameAs 2057645411 @default.
• W2057645411 citedByCount "166" @default.
• W2057645411 countsByYear W20576454112012 @default.
• W2057645411 countsByYear W20576454112013 @default.
• W2057645411 countsByYear W20576454112014 @default.
• W2057645411 countsByYear W20576454112015 @default.
• W2057645411 countsByYear W20576454112016 @default.
• W2057645411 countsByYear W20576454112017 @default.
• W2057645411 countsByYear W20576454112018 @default.
• W2057645411 countsByYear W20576454112019 @default.
• W2057645411 countsByYear W20576454112020 @default.
• W2057645411 countsByYear W20576454112021 @default.
• W2057645411 countsByYear W20576454112022 @default.
• W2057645411 countsByYear W20576454112023 @default.
• W2057645411 crossrefType "journal-article" @default.
• W2057645411 hasAuthorship W2057645411A5024014571 @default.
• W2057645411 hasAuthorship W2057645411A5027323609 @default.
• W2057645411 hasAuthorship W2057645411A5028985183 @default.
• W2057645411 hasAuthorship W2057645411A5066563633 @default.
• W2057645411 hasBestOaLocation W20576454111 @default.
• W2057645411 hasConcept C104317684 @default.
• W2057645411 hasConcept C11242284 @default.
• W2057645411 hasConcept C125965507 @default.
• W2057645411 hasConcept C150194340 @default.
• W2057645411 hasConcept C153911025 @default.
• W2057645411 hasConcept C24586158 @default.
• W2057645411 hasConcept C2781172350 @default.
• W2057645411 hasConcept C501734568 @default.
• W2057645411 hasConcept C54355233 @default.
• W2057645411 hasConcept C552990157 @default.
• W2057645411 hasConcept C86803240 @default.
• W2057645411 hasConceptScore W2057645411C104317684 @default.
• W2057645411 hasConceptScore W2057645411C11242284 @default.
• W2057645411 hasConceptScore W2057645411C125965507 @default.
• W2057645411 hasConceptScore W2057645411C150194340 @default.
• W2057645411 hasConceptScore W2057645411C153911025 @default.
• W2057645411 hasConceptScore W2057645411C24586158 @default.
• W2057645411 hasConceptScore W2057645411C2781172350 @default.
• W2057645411 hasConceptScore W2057645411C501734568 @default.
• W2057645411 hasConceptScore W2057645411C54355233 @default.
• W2057645411 hasConceptScore W2057645411C552990157 @default.
• W2057645411 hasConceptScore W2057645411C86803240 @default.
• W2057645411 hasIssue "21" @default.
• W2057645411 hasLocation W20576454111 @default.
• W2057645411 hasLocation W20576454112 @default.

• next