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- W2057646099 abstract "Melanomas are rare in albinos, although the incidence of solar radiation-induced skin tumors is extremely high because of the absence of photoprotective melanin. This report describes a 40-year-old white woman with tyrosinase-negative oculocutaneous albinism who developed four primary amelanotic melanomas–three of the superficial spreading and one of the nodular type–and, in addition, displayed nevi that exhibited histologically the characteristic features of dysplastic nevi. The concomitant occurrence of multiple primary melanomas and several dysplastic nevi classifies the patient's condition as “dysplastic nevus syndrome,” which to our knowledge has not been described in albinism so far. Melanomas are rare in albinos, although the incidence of solar radiation-induced skin tumors is extremely high because of the absence of photoprotective melanin. This report describes a 40-year-old white woman with tyrosinase-negative oculocutaneous albinism who developed four primary amelanotic melanomas–three of the superficial spreading and one of the nodular type–and, in addition, displayed nevi that exhibited histologically the characteristic features of dysplastic nevi. The concomitant occurrence of multiple primary melanomas and several dysplastic nevi classifies the patient's condition as “dysplastic nevus syndrome,” which to our knowledge has not been described in albinism so far." @default.
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- W2057646099 date "1984-10-01" @default.
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- W2057646099 title "Dysplastic nevus syndrome with multiple primary amelanotic melanomas in oculocutaneous albinism" @default.
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- W2057646099 doi "https://doi.org/10.1016/s0190-9622(84)70230-1" @default.
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