FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057646479> ?p ?o ?g. }

• W2057646479 endingPage "952" @default.
• W2057646479 startingPage "940" @default.
• W2057646479 abstract "Exchanging each of the conserved aromatic residues of the NPxxY(x)(5,6)F sequence (at the boundary of helices 7 and 8) generated variants of the A(1) adenosine receptor that were retained within the cell. The mutations disconnected a link between alpha-helix 7 and cytosolic helix 8, likely destabilizing the structure of the proximal carboxyl terminus. The mutant receptors were rescued by incubation of cells with a pharmacochaperone, a membrane-permeable ligand that homosterically binds to the receptor; pharmacochaperoning restored the density of functional receptors at the plasma membrane. The following observations support the assumption that retention and the site of pharmacochaperone action were within bounds of the endoplasmic reticulum (ER): 1) the retained receptor colocalized with an ER marker; 2) pharmacochaperoning initiated receptor transfer to Golgi stacks; and 3) the inhibitor of glycoprotein synthesis tunicamycin suppressed receptor chaperoning. Our data are consistent with the hypothesis that pharmacochaperoning stabilizes the structure of late folding intermediates and lifts a block on maturation, allowing the receptors to exit from the ER. We suggest that the ER-associated 40-kDa heat shock protein family member D(1) receptor interacting protein 78 (DRiP78; M(r), approximately 78,000) represents a model executor of quality control. Overexpressed DRiP78 interacted physically with the A(1) receptor, inhibited export to the plasma membrane, and in this action was selective for the mutants relative to the wild-type receptor. Both agonist and antagonist were effective chaperone ligands. Thus, occupancy of the binding pocket corrected the mutation-induced disorder, indicating a mutual impingement of the transmembrane domain and the proximal carboxyl terminus in establishing the stable receptor fold." @default.
• W2057646479 created "2016-06-24" @default.
• W2057646479 creator A5003170013 @default.
• W2057646479 creator A5038931109 @default.
• W2057646479 creator A5060360807 @default.
• W2057646479 creator A5068571011 @default.
• W2057646479 creator A5078767303 @default.
• W2057646479 creator A5080596484 @default.
• W2057646479 date "2010-03-10" @default.
• W2057646479 modified "2023-10-01" @default.
• W2057646479 title "Pharmacochaperoning of the A₁Adenosine Receptor Is Contingent on the Endoplasmic Reticulum" @default.
• W2057646479 cites W1481591305 @default.
• W2057646479 cites W1527823690 @default.
• W2057646479 cites W1968115961 @default.
• W2057646479 cites W1976409519 @default.
• W2057646479 cites W1987771931 @default.
• W2057646479 cites W1993677150 @default.
• W2057646479 cites W1996359225 @default.
• W2057646479 cites W2002165169 @default.
• W2057646479 cites W2013087877 @default.
• W2057646479 cites W2016172145 @default.
• W2057646479 cites W2024143047 @default.
• W2057646479 cites W2031025422 @default.
• W2057646479 cites W2040310721 @default.
• W2057646479 cites W2041660879 @default.
• W2057646479 cites W2045342279 @default.
• W2057646479 cites W2046467234 @default.
• W2057646479 cites W2048410843 @default.
• W2057646479 cites W2050020385 @default.
• W2057646479 cites W2054314612 @default.
• W2057646479 cites W2054772758 @default.
• W2057646479 cites W2061134762 @default.
• W2057646479 cites W2075415414 @default.
• W2057646479 cites W2076589912 @default.
• W2057646479 cites W2083928750 @default.
• W2057646479 cites W2086435366 @default.
• W2057646479 cites W2089248947 @default.
• W2057646479 cites W2095822220 @default.
• W2057646479 cites W2101968602 @default.
• W2057646479 cites W2104477830 @default.
• W2057646479 cites W2108412187 @default.
• W2057646479 cites W2148992616 @default.
• W2057646479 cites W2155062549 @default.
• W2057646479 cites W2157907012 @default.
• W2057646479 cites W2162194520 @default.
• W2057646479 cites W2165050822 @default.
• W2057646479 cites W2168210014 @default.
• W2057646479 doi "https://doi.org/10.1124/mol.110.063511" @default.
• W2057646479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20219842" @default.
• W2057646479 hasPublicationYear "2010" @default.
• W2057646479 type Work @default.
• W2057646479 sameAs 2057646479 @default.
• W2057646479 citedByCount "36" @default.
• W2057646479 countsByYear W20576464792012 @default.
• W2057646479 countsByYear W20576464792013 @default.
• W2057646479 countsByYear W20576464792014 @default.
• W2057646479 countsByYear W20576464792015 @default.
• W2057646479 countsByYear W20576464792016 @default.
• W2057646479 countsByYear W20576464792017 @default.
• W2057646479 countsByYear W20576464792018 @default.
• W2057646479 countsByYear W20576464792019 @default.
• W2057646479 countsByYear W20576464792020 @default.
• W2057646479 countsByYear W20576464792021 @default.
• W2057646479 countsByYear W20576464792022 @default.
• W2057646479 crossrefType "journal-article" @default.
• W2057646479 hasAuthorship W2057646479A5003170013 @default.
• W2057646479 hasAuthorship W2057646479A5038931109 @default.
• W2057646479 hasAuthorship W2057646479A5060360807 @default.
• W2057646479 hasAuthorship W2057646479A5068571011 @default.
• W2057646479 hasAuthorship W2057646479A5078767303 @default.
• W2057646479 hasAuthorship W2057646479A5080596484 @default.
• W2057646479 hasConcept C104317684 @default.
• W2057646479 hasConcept C118892022 @default.
• W2057646479 hasConcept C119062480 @default.
• W2057646479 hasConcept C143065580 @default.
• W2057646479 hasConcept C158617107 @default.
• W2057646479 hasConcept C170493617 @default.
• W2057646479 hasConcept C17971392 @default.
• W2057646479 hasConcept C2778043179 @default.
• W2057646479 hasConcept C55493867 @default.
• W2057646479 hasConcept C86803240 @default.
• W2057646479 hasConcept C95444343 @default.
• W2057646479 hasConceptScore W2057646479C104317684 @default.
• W2057646479 hasConceptScore W2057646479C118892022 @default.
• W2057646479 hasConceptScore W2057646479C119062480 @default.
• W2057646479 hasConceptScore W2057646479C143065580 @default.
• W2057646479 hasConceptScore W2057646479C158617107 @default.
• W2057646479 hasConceptScore W2057646479C170493617 @default.
• W2057646479 hasConceptScore W2057646479C17971392 @default.
• W2057646479 hasConceptScore W2057646479C2778043179 @default.
• W2057646479 hasConceptScore W2057646479C55493867 @default.
• W2057646479 hasConceptScore W2057646479C86803240 @default.
• W2057646479 hasConceptScore W2057646479C95444343 @default.
• W2057646479 hasIssue "6" @default.
• W2057646479 hasLocation W20576464791 @default.
• W2057646479 hasLocation W20576464792 @default.
• W2057646479 hasOpenAccess W2057646479 @default.
• W2057646479 hasPrimaryLocation W20576464791 @default.

• next