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- W2057647416 abstract "Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death. Since the identification of the huntingtin gene and the characteristic expanded CAG repeat/polyglutamine mutation, multiple murine genetic models and one rat genetic model have been generated. These models fall into two general categories: transgenic models with ectopic expression of the characteristic expanded CAG codon mutation, and knock-in models with expression of mutant huntingtin under control of endogenous regulatory elements. Rodent genetic models are valuable tools for studying mechanisms of pathogenesis in HD and for preclinical evaluation of possible therapies. In this mini-review, we provide a concise comparative summary of rodent genetic models of HD." @default.
- W2057647416 created "2016-06-24" @default.
- W2057647416 creator A5002817065 @default.
- W2057647416 creator A5026359392 @default.
- W2057647416 creator A5071895029 @default.
- W2057647416 date "2008-10-01" @default.
- W2057647416 modified "2023-10-16" @default.
- W2057647416 title "Rodent genetic models of Huntington disease" @default.
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- W2057647416 doi "https://doi.org/10.1016/j.nbd.2008.06.005" @default.
- W2057647416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18638556" @default.
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