FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057650704> ?p ?o ?g. }

• W2057650704 endingPage "191" @default.
• W2057650704 startingPage "184" @default.
• W2057650704 abstract "Experimental studies have suggested that constant intravenous infusion would be preferable to conventional intermittent bolus administration of beta-lactam antibiotics for serious Gram-negative infections. Severe melioidosis (Burkholderia pseudomallei infection) carries a mortality over 40% despite treatment with high dose ceftazidime. The aim of this study was to measure the pharmacokinetic and pharmacodynamic effects of continuous infusion of ceftazidime vs intermittent bolus dosing in septicaemic melioidosis.Patients with suspected septicaemic melioidosis were randomised to receive ceftazidime 40 mg kg(-1) 8 hourly by bolus injection or 4 mg kg(-1) h(-1) by constant infusion following a 12 mg kg(-1) priming dose and pharmacokinetic and pharmacodynamic parameters were compared.Of the 34 patients studied 16 (59%) died. Twenty patients had cultures positive for B. pseudomallei of whom 12 (60%) died. The median MIC90 of B. pseudomallei was 2 mg l(-1), giving a minimum target concentration (4*MIC) of 8 mg l(-1). The median (range) estimated total apparent volume of distribution, systemic clearance and terminal elimination half-lives of ceftazidime were 0.468 (0.241-0. 573) l kg(-1), 0.058 (0.005-0.159) l kg(-1) h(-1) and 7.74 (1.95-44.71) h, respectively. Clearance of ceftazidime and creatinine clearance were correlated closely (r = 0.71; P < 0.001) and there was no evidence of significant nonrenal clearance.Simulations based on these data and the ceftazidime sensitivity of the B. pseudomallei isolates indicated that administration by constant infusion would allow significant dose reduction and cost saving. With conventional 8 h intermittent dosing to patients with normal renal function, plasma ceftazidime concentrations could fall below the target concentration but this would be unlikely with a constant infusion. Correction for renal failure, which is common in patients with meliodosis is Clearance = k(*) creatinine clearance where k = 0.72. Calculation of a loading dose gives median (range) values of loading dose, DL of 18.7 mg kg(-1) (9.5-23) and infusion rate I = 3.5 mg k(-1) h(-1) (0.4-13) (which equals 84 mg kg(-1) day(-1)). A nomogram for adjustment in renal failure is given." @default.
• W2057650704 created "2016-06-24" @default.
• W2057650704 creator A5015402059 @default.
• W2057650704 creator A5017439674 @default.
• W2057650704 creator A5046547648 @default.
• W2057650704 creator A5049241523 @default.
• W2057650704 creator A5050764672 @default.
• W2057650704 creator A5058967121 @default.
• W2057650704 creator A5060463156 @default.
• W2057650704 creator A5085356323 @default.
• W2057650704 date "2000-08-01" @default.
• W2057650704 modified "2023-10-07" @default.
• W2057650704 title "Pharmacokinetic-pharmacodynamic evaluation of ceftazidime continuous infusion <i>vs</i> intermittent bolus injection in septicaemic melioidosis" @default.
• W2057650704 cites W1550111394 @default.
• W2057650704 cites W1807462308 @default.
• W2057650704 cites W1894308928 @default.
• W2057650704 cites W1968142908 @default.
• W2057650704 cites W1969084312 @default.
• W2057650704 cites W1973073979 @default.
• W2057650704 cites W1976679876 @default.
• W2057650704 cites W1977449346 @default.
• W2057650704 cites W1978999675 @default.
• W2057650704 cites W1980030251 @default.
• W2057650704 cites W1982986165 @default.
• W2057650704 cites W1990891055 @default.
• W2057650704 cites W1999279226 @default.
• W2057650704 cites W2005000232 @default.
• W2057650704 cites W2009720606 @default.
• W2057650704 cites W2021615041 @default.
• W2057650704 cites W2038074430 @default.
• W2057650704 cites W2060990271 @default.
• W2057650704 cites W2069808962 @default.
• W2057650704 cites W2071578083 @default.
• W2057650704 cites W2078251568 @default.
• W2057650704 cites W2089666099 @default.
• W2057650704 cites W2090430946 @default.
• W2057650704 cites W2101891378 @default.
• W2057650704 cites W2104759086 @default.
• W2057650704 cites W2114422486 @default.
• W2057650704 cites W2115779495 @default.
• W2057650704 cites W2119577847 @default.
• W2057650704 cites W2131171455 @default.
• W2057650704 cites W2132869689 @default.
• W2057650704 cites W2136028041 @default.
• W2057650704 cites W2137304822 @default.
• W2057650704 cites W2141173497 @default.
• W2057650704 cites W2154381036 @default.
• W2057650704 cites W2157336791 @default.
• W2057650704 cites W2158308518 @default.
• W2057650704 cites W2158502877 @default.
• W2057650704 cites W2166840599 @default.
• W2057650704 cites W2398156413 @default.
• W2057650704 cites W2408820156 @default.
• W2057650704 cites W2410400083 @default.
• W2057650704 cites W2416543865 @default.
• W2057650704 cites W2015920915 @default.
• W2057650704 doi "https://doi.org/10.1111/j.1365-2125.2000.00179.x" @default.
• W2057650704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064972" @default.
• W2057650704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10930972" @default.
• W2057650704 hasPublicationYear "2000" @default.
• W2057650704 type Work @default.
• W2057650704 sameAs 2057650704 @default.
• W2057650704 citedByCount "89" @default.
• W2057650704 countsByYear W20576507042012 @default.
• W2057650704 countsByYear W20576507042013 @default.
• W2057650704 countsByYear W20576507042014 @default.
• W2057650704 countsByYear W20576507042015 @default.
• W2057650704 countsByYear W20576507042016 @default.
• W2057650704 countsByYear W20576507042017 @default.
• W2057650704 countsByYear W20576507042018 @default.
• W2057650704 countsByYear W20576507042019 @default.
• W2057650704 countsByYear W20576507042020 @default.
• W2057650704 countsByYear W20576507042021 @default.
• W2057650704 countsByYear W20576507042022 @default.
• W2057650704 countsByYear W20576507042023 @default.
• W2057650704 crossrefType "journal-article" @default.
• W2057650704 hasAuthorship W2057650704A5015402059 @default.
• W2057650704 hasAuthorship W2057650704A5017439674 @default.
• W2057650704 hasAuthorship W2057650704A5046547648 @default.
• W2057650704 hasAuthorship W2057650704A5049241523 @default.
• W2057650704 hasAuthorship W2057650704A5050764672 @default.
• W2057650704 hasAuthorship W2057650704A5058967121 @default.
• W2057650704 hasAuthorship W2057650704A5060463156 @default.
• W2057650704 hasAuthorship W2057650704A5085356323 @default.
• W2057650704 hasBestOaLocation W20576507042 @default.
• W2057650704 hasConcept C111113717 @default.
• W2057650704 hasConcept C112705442 @default.
• W2057650704 hasConcept C126322002 @default.
• W2057650704 hasConcept C139254425 @default.
• W2057650704 hasConcept C142724271 @default.
• W2057650704 hasConcept C2776968632 @default.
• W2057650704 hasConcept C2777288759 @default.
• W2057650704 hasConcept C2777637488 @default.
• W2057650704 hasConcept C2779110727 @default.
• W2057650704 hasConcept C2779775996 @default.
• W2057650704 hasConcept C3019249092 @default.
• W2057650704 hasConcept C42219234 @default.
• W2057650704 hasConcept C43376680 @default.

• next