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• W2057651775 abstract "1. Baker's yeast, when incubated in the absence of phosphate, more than doubles its content of protein nitrogen and that of its organic non-protein nitrogen without any net increase of its content of purine compounds. On the other hand, when phosphate-starved yeast cells are transferred to a phosphate-containing medium, ourine and nucleic acid biosynthesis is resumed at rates which are approximately four times larger than those of the simultaneous protein and amino acid biosynthesis. (The rates were measured as the per cent increments of the initial concentrations of the respective cell constituents during a given time of incubation.) 2. By the use of ethionine as a reagent for the intracellular trapping of adenine groups it has been demonstrated that yeast cells are capable of intense de novo synthesis of adenine groups without any simultaneous formation of RNA. 3. Methionine has no significant role as a donor of one-carbon groups for purine biosynthesis in yeast. 4. Acid-insoluble intracellular polyphosphates are utilized for nucleic acid biosynthesis in yeast as efficiently as orthophosphate present in the nutrient solutions. On the other hand, large accumulations of inorganic polyphosphates occur in yeast cells under conditions of complete inhibition of RNA formation." @default.
• W2057651775 created "2016-06-24" @default.
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• W2057651775 date "1956-01-01" @default.
• W2057651775 modified "2023-10-14" @default.
• W2057651775 title "The effects of certain nutritional conditions on the formation of purines and of ribonucleic acid in baker's yeast" @default.
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• W2057651775 doi "https://doi.org/10.1016/0006-3002(56)90272-4" @default.
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