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- W2057656178 abstract "Oral Epithelial dysplasia may be a white, red or mixed patch that may affect several sites of themouth. Chemo-induced precancerous lesions are standard model to study cancer on the oral cavity.The use of Laser photobiomodulation on the oral care is a standard procedure these days and it isknown that it proliferative effects on both cells and tissues depending on dose, wavelengths andother parameters. The aim of this study was to assess the effect of laser light on the evolution ofchemo-induced epithelial dysplasia on the hamster cheek pouch model. Sixteen animals weredivided into four groups: Control (n=8), Laser λ660nm (n=4), and Laser λ790nm (n=4). DMBAinduction was carried out three times a week. All animals presented epithelial dysplasia seven daysafter first induction. When appropriate, laser (λ660nm or λ790nm, 30/40mW, Φ ~ 3mm, 4J/cm2) wasused at 48 h interval during two weeks. Chemo-induction continued during all experimental period(6 weeks). Following animal death, specimens were taken, routinely process to wax, cut and stainedwith H.E. Slides were analyzed under light microscopy by an oral pathologist using WHO (2005)criteria for epithelial dysplasia. At the end of the experiment, 100% of control specimens showedmild epithelial dysplasia. On laser irradiated animals, 75% of the specimens showed mild epithelialdysplasia and 25% showed moderate ones extending beyond the medium third of the epithelium. Itwas concluded that the use of both wavelength and a dose of 4J/cm2 may increase the severity oforal epithelial dysplasia." @default.
- W2057656178 created "2016-06-24" @default.
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- W2057656178 date "2009-02-12" @default.
- W2057656178 modified "2023-10-18" @default.
- W2057656178 title "Effects of visible or IR Laser light on the progression of chemo-induced oral dysplasia: In vivo study on the hamster cheek pouch model" @default.
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- W2057656178 doi "https://doi.org/10.1117/12.807950" @default.
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