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- W2057671372 abstract "Abstract Estradiol-receptor complex from rat uterus has been shown to have an affinity for DNA-cellulose and ATP-Sepharose. This DNA and ATP binding of estradiol receptor was observed to be sensitive to low concentrations (0.01–0.2mM) of aurintricarboxylic acid. The inhibitor was more effective when added to preparations that contained activated estradiol-receptor complex. Steroid binding properties of the receptor remained intact under the above conditions as judged by charcoal adsorption assays and sucrose gradient analysis. In addition, a 40% inhibition in the nuclear translocation of cytosol estradiol receptor was observed when rat uteri were incubated with 10nM [ 3 H] estradiol under an atmosphere of 95% O 2 and 5% CO 2 in the presence of aurintric-carboxylic acid. Our results suggest that aurintricarboxylic acid is an effective inhibitor of rat uterine estradiol receptor and that it may be acting by interfering with site(s) on the estradiol receptor which may be exposed upon activation and are subsequently involved in processes such as ATP binding, nuclear uptake and DNA binding." @default.
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- W2057671372 date "1980-09-01" @default.
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- W2057671372 title "Inhibition of rat uterine estradiol receptor by aurintricarboxylic acid" @default.
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- W2057671372 doi "https://doi.org/10.1016/0024-3205(80)90467-1" @default.
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