Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057673710> ?p ?o ?g. }
- W2057673710 endingPage "1597" @default.
- W2057673710 startingPage "1590" @default.
- W2057673710 abstract "Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing, though not lifesaving, transplant. Kidney cotransplantation along with a short course of high-dose immunosuppression enables tolerance of heart allografts across a full major histocompatibility complex (MHC) mismatch. In this study, we investigated whether tolerance of VCAs across full MHC disparities could be achieved in animals already tolerant of heart and kidney allografts.Miniature swine that were tolerant of heart and/or kidney allografts long term underwent transplantation of myocutaneous VCA across the same MHC barrier. Before VCA transplant, group 1 (n = 3) underwent class I-mismatched kidney transplantation; group 2 (n = 3) underwent 2 sequential class I-mismatched kidney transplantations; group 3 (n = 2) underwent haploidentical MHC-mismatched heart/kidney transplantation; and group 4 (n = 2) underwent full MHC-mismatched heart/kidney transplantation.All 3 animals in group 1 and 2 of 3 animals in group 2 showed skin rejection within 85 days; 1 animal in group 2 showed prolonged skin survival longer than 200 days. Animals in groups 3 and 4 showed skin rejection within 30 days and regained in vitro evidence of donor responsiveness.This is the first preclinical study in which hearts, kidneys, and VCAs have been transplanted into the same recipient. Despite VCA rejection, tolerance of heart and kidney allografts was maintained. These results suggest that regulatory tolerance of skin is possible but not generally achieved by the same level of immunomodulation that is capable of inducing tolerance of heart and kidney allografts. Achieving tolerance of skin may require additional immunomodulatory therapies." @default.
- W2057673710 created "2016-06-24" @default.
- W2057673710 creator A5007827494 @default.
- W2057673710 creator A5019248592 @default.
- W2057673710 creator A5031789505 @default.
- W2057673710 creator A5043223305 @default.
- W2057673710 creator A5048238441 @default.
- W2057673710 creator A5049282725 @default.
- W2057673710 creator A5049755562 @default.
- W2057673710 creator A5053662389 @default.
- W2057673710 creator A5058625301 @default.
- W2057673710 creator A5073338357 @default.
- W2057673710 creator A5084623835 @default.
- W2057673710 creator A5086748086 @default.
- W2057673710 creator A5086773006 @default.
- W2057673710 date "2015-08-01" @default.
- W2057673710 modified "2023-10-07" @default.
- W2057673710 title "Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts" @default.
- W2057673710 cites W1498766363 @default.
- W2057673710 cites W1525793898 @default.
- W2057673710 cites W1570981915 @default.
- W2057673710 cites W1580156494 @default.
- W2057673710 cites W1603687683 @default.
- W2057673710 cites W1625754474 @default.
- W2057673710 cites W1737600104 @default.
- W2057673710 cites W1902067565 @default.
- W2057673710 cites W1969638726 @default.
- W2057673710 cites W1971015366 @default.
- W2057673710 cites W1975363090 @default.
- W2057673710 cites W1977703774 @default.
- W2057673710 cites W1983491684 @default.
- W2057673710 cites W198571174 @default.
- W2057673710 cites W1988867818 @default.
- W2057673710 cites W1989811385 @default.
- W2057673710 cites W1990118856 @default.
- W2057673710 cites W1993233385 @default.
- W2057673710 cites W2002129939 @default.
- W2057673710 cites W2009237008 @default.
- W2057673710 cites W2009473574 @default.
- W2057673710 cites W2022016766 @default.
- W2057673710 cites W2039334806 @default.
- W2057673710 cites W2040576277 @default.
- W2057673710 cites W2045114099 @default.
- W2057673710 cites W2049527128 @default.
- W2057673710 cites W2056264750 @default.
- W2057673710 cites W2058044331 @default.
- W2057673710 cites W2065982378 @default.
- W2057673710 cites W2066761842 @default.
- W2057673710 cites W2075288731 @default.
- W2057673710 cites W2079111657 @default.
- W2057673710 cites W2081741735 @default.
- W2057673710 cites W2086461928 @default.
- W2057673710 cites W2087519572 @default.
- W2057673710 cites W2088489333 @default.
- W2057673710 cites W2093240750 @default.
- W2057673710 cites W2107841942 @default.
- W2057673710 cites W2147495112 @default.
- W2057673710 cites W2155144605 @default.
- W2057673710 cites W2155314901 @default.
- W2057673710 cites W2163518919 @default.
- W2057673710 cites W2275549384 @default.
- W2057673710 cites W2410539431 @default.
- W2057673710 cites W2414106361 @default.
- W2057673710 cites W4233084236 @default.
- W2057673710 cites W4250587277 @default.
- W2057673710 cites W4294349031 @default.
- W2057673710 doi "https://doi.org/10.1097/tp.0000000000000681" @default.
- W2057673710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4551576" @default.
- W2057673710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25757218" @default.
- W2057673710 hasPublicationYear "2015" @default.
- W2057673710 type Work @default.
- W2057673710 sameAs 2057673710 @default.
- W2057673710 citedByCount "9" @default.
- W2057673710 countsByYear W20576737102016 @default.
- W2057673710 countsByYear W20576737102017 @default.
- W2057673710 countsByYear W20576737102018 @default.
- W2057673710 countsByYear W20576737102020 @default.
- W2057673710 countsByYear W20576737102021 @default.
- W2057673710 crossrefType "journal-article" @default.
- W2057673710 hasAuthorship W2057673710A5007827494 @default.
- W2057673710 hasAuthorship W2057673710A5019248592 @default.
- W2057673710 hasAuthorship W2057673710A5031789505 @default.
- W2057673710 hasAuthorship W2057673710A5043223305 @default.
- W2057673710 hasAuthorship W2057673710A5048238441 @default.
- W2057673710 hasAuthorship W2057673710A5049282725 @default.
- W2057673710 hasAuthorship W2057673710A5049755562 @default.
- W2057673710 hasAuthorship W2057673710A5053662389 @default.
- W2057673710 hasAuthorship W2057673710A5058625301 @default.
- W2057673710 hasAuthorship W2057673710A5073338357 @default.
- W2057673710 hasAuthorship W2057673710A5084623835 @default.
- W2057673710 hasAuthorship W2057673710A5086748086 @default.
- W2057673710 hasAuthorship W2057673710A5086773006 @default.
- W2057673710 hasBestOaLocation W20576737102 @default.
- W2057673710 hasConcept C126322002 @default.
- W2057673710 hasConcept C126894567 @default.
- W2057673710 hasConcept C141071460 @default.
- W2057673710 hasConcept C147483822 @default.
- W2057673710 hasConcept C188280979 @default.