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- W2057677658 abstract "The hereditary disorders of hemoglobin constitute the most common genetic diseases worldwide. They are caused by mutations within the alpha- or beta-globin chains, leading to structural defects in the hemoglobin molecule, altered synthesis of globin chains, or hereditary persistence of fetal hemoglobin. As equal numbers of alpha- and beta-globin chains are needed for normal functioning of hemoglobin, mutations that diminish production of either of these two subunits produce a thalassemic state. Similarly, modified globin proteins can manifest as sickle cell disease. Patients with these diseases carry a heavy burden of morbidity and early mortality." @default.
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- W2057677658 date "2005-04-01" @default.
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- W2057677658 title "Iron overload in thalassemia and sickle cell disease" @default.
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- W2057677658 doi "https://doi.org/10.1053/j.seminhematol.2005.01.005" @default.
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