Matches in SemOpenAlex for { <https://semopenalex.org/work/W2057680462> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2057680462 abstract "Expression of integrin αvβ3 is upregulated in a number of cancers including colon, pancreas, lung and breast. Previous studies demonstrated that near infrared (NIR) fluorescent probes designed to target αvβ3 accumulated both in vitro and in vivo in αvβ3-positive tumor cells. To evaluate the selectivity of some NIR-labeled RGD peptides for αvβ3, the molecular probes were incubated in different cells, including the αvβ3-positive U87 and A549 cells, and αvβ3-negative HT29 cells. Whereas the RGD compounds tested internalized in the A549 cells, their uptake by the HT29 cell line, which is positive for αvβ5 and αvβ6, was low. The uptake of these probes in U87 depended on the structural features of the compounds. Further studies with functional blocking antibodies showed that the internalization in the αvβ3-positive cells may be mediated by different integrin receptor subtypes. The preliminary results suggest that the internalization of linear RGD peptides is mediated by the αvβ3 heterodimer but rearrangement of the peptide sequence could alter the selectivity of the molecular probes for different integrin subunits in the dimeric α and β proteins. Thus, a careful choice of RGD peptides can be used to monitor the functional status of different integrins in cells and tissues." @default.
- W2057680462 created "2016-06-24" @default.
- W2057680462 creator A5038503670 @default.
- W2057680462 creator A5046251414 @default.
- W2057680462 creator A5074819649 @default.
- W2057680462 creator A5078448484 @default.
- W2057680462 creator A5086585564 @default.
- W2057680462 date "2006-02-09" @default.
- W2057680462 modified "2023-09-23" @default.
- W2057680462 title "Internalization of RGD peptide conjugates of near-infrared fluorescent probes in different cell lines occurs via different integrin receptor subtypes" @default.
- W2057680462 doi "https://doi.org/10.1117/12.647811" @default.
- W2057680462 hasPublicationYear "2006" @default.
- W2057680462 type Work @default.
- W2057680462 sameAs 2057680462 @default.
- W2057680462 citedByCount "1" @default.
- W2057680462 countsByYear W20576804622013 @default.
- W2057680462 crossrefType "proceedings-article" @default.
- W2057680462 hasAuthorship W2057680462A5038503670 @default.
- W2057680462 hasAuthorship W2057680462A5046251414 @default.
- W2057680462 hasAuthorship W2057680462A5074819649 @default.
- W2057680462 hasAuthorship W2057680462A5078448484 @default.
- W2057680462 hasAuthorship W2057680462A5086585564 @default.
- W2057680462 hasConcept C121332964 @default.
- W2057680462 hasConcept C12554922 @default.
- W2057680462 hasConcept C139770010 @default.
- W2057680462 hasConcept C153911025 @default.
- W2057680462 hasConcept C170493617 @default.
- W2057680462 hasConcept C185592680 @default.
- W2057680462 hasConcept C195687474 @default.
- W2057680462 hasConcept C202751555 @default.
- W2057680462 hasConcept C2779281246 @default.
- W2057680462 hasConcept C54355233 @default.
- W2057680462 hasConcept C55493867 @default.
- W2057680462 hasConcept C62520636 @default.
- W2057680462 hasConcept C81729549 @default.
- W2057680462 hasConcept C81885089 @default.
- W2057680462 hasConcept C86803240 @default.
- W2057680462 hasConcept C91881484 @default.
- W2057680462 hasConcept C95444343 @default.
- W2057680462 hasConceptScore W2057680462C121332964 @default.
- W2057680462 hasConceptScore W2057680462C12554922 @default.
- W2057680462 hasConceptScore W2057680462C139770010 @default.
- W2057680462 hasConceptScore W2057680462C153911025 @default.
- W2057680462 hasConceptScore W2057680462C170493617 @default.
- W2057680462 hasConceptScore W2057680462C185592680 @default.
- W2057680462 hasConceptScore W2057680462C195687474 @default.
- W2057680462 hasConceptScore W2057680462C202751555 @default.
- W2057680462 hasConceptScore W2057680462C2779281246 @default.
- W2057680462 hasConceptScore W2057680462C54355233 @default.
- W2057680462 hasConceptScore W2057680462C55493867 @default.
- W2057680462 hasConceptScore W2057680462C62520636 @default.
- W2057680462 hasConceptScore W2057680462C81729549 @default.
- W2057680462 hasConceptScore W2057680462C81885089 @default.
- W2057680462 hasConceptScore W2057680462C86803240 @default.
- W2057680462 hasConceptScore W2057680462C91881484 @default.
- W2057680462 hasConceptScore W2057680462C95444343 @default.
- W2057680462 hasLocation W20576804621 @default.
- W2057680462 hasOpenAccess W2057680462 @default.
- W2057680462 hasPrimaryLocation W20576804621 @default.
- W2057680462 hasRelatedWork W1836946286 @default.
- W2057680462 hasRelatedWork W1966285200 @default.
- W2057680462 hasRelatedWork W1969139934 @default.
- W2057680462 hasRelatedWork W1987002621 @default.
- W2057680462 hasRelatedWork W2040129605 @default.
- W2057680462 hasRelatedWork W2058985483 @default.
- W2057680462 hasRelatedWork W2060553988 @default.
- W2057680462 hasRelatedWork W2063705161 @default.
- W2057680462 hasRelatedWork W2069802714 @default.
- W2057680462 hasRelatedWork W2106467306 @default.
- W2057680462 isParatext "false" @default.
- W2057680462 isRetracted "false" @default.
- W2057680462 magId "2057680462" @default.
- W2057680462 workType "article" @default.