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- W2057681849 abstract "The adrenergic agonist norepinephrine can exert its influence on cell function by activating both α- and β-adrenergic receptors. In astrocytes, the α-adrenergic receptor activity of norepinephrine is known to inhibit the cyclic AMP response elicited by its action at β-adrenergic receptors. Pharmacological studies were conducted to identify the subtype of α-adrenergic receptor which mediates this inhibitory action. The α2-adrenergic antagonist yohimbine potentiated the cyclic AMP response elicited by norepinephrine, whereas the α1-adrenergic antagonist prazosin did not affect the response. The α2-adrenergic agonist clonidine inhibited the cyclic AMP response elicited by the β-adrenergic agonist isoproterenol and this inhibition could be blocked by yohimbine but not by prazosin. In contrast, the α1-adrenergic agonist phenylephrine did not inhibit the cyclic AMP response to isoproterenol. These studies indicate that the inhibitory action of norepinephrine is mediated by its action at α2-adrenergic receptors." @default.
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- W2057681849 date "1989-01-01" @default.
- W2057681849 modified "2023-09-27" @default.
- W2057681849 title "Pharmacological identification of the ?-adrenergic receptor type which inhibits the ?-adrenergic activated adenylate cyclase system in cultured astrocytes" @default.
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- W2057681849 doi "https://doi.org/10.1002/glia.440020209" @default.
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